Monocyte Profiles and Their Association with Depression Severity and Functional Disability

Journal of Psychiatric Research, Год журнала: 2025, Номер 184, С. 272 - 278

Опубликована: Март 6, 2025

Язык: Английский

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Unbalance CD4+IL-10+ and more activated and exhausted CD8+ lymphocytes characterized patients with a Major Depressive Episode.

Journal of Pharmacology and Experimental Therapeutics, Год журнала: 2025, Номер unknown, С. 103563 - 103563

Опубликована: Март 1, 2025

Depression is a highly prevalent psychiatric condition referred to as major depressive episode (MDE). The underlying causes and mechanisms of depression remain poorly elucidated and, in consequence, the efficacy current therapies. Inflammation has been proposed contribute pathophysiology MDE with altered innate adaptive immune responses. present work aimed shed light on effector CD4+ T helper (Th) cell subsets response activation exhaustion CD8+ lymphocytes peripheral blood patients MDE. Patients (n = 57) healthy controls (HCs) 34) were recruited. intracellular production interferon (IFN) γ (Th1), interleukin (IL)-17 (Th17), IL-10 (CD4+ IL-10+) exhausted status evaluated by flow cytometry. frequencies Th1 Th17 cells did not show statistical differences, but lower percentage CD4+IL-10+ (P < 0.05) CD4+IFNγ+IL-10+ .01) found compared HCs. reduction population negatively correlated number episodes .05 P duration illness .01). A higher proportion activated CD8+CD69+ .0001) potentially phenotype CD8+PD1+LAG3+ observed, which positively severity, episodes, Altogether, are characterized unbalanced Th1/Th17/CD4+IL-10+ increased cytotoxic cells. Therapeutic strategies restoring this balance effective control inflammatory responses may be beneficial SIGNIFICANCE STATEMENT: (MDE) remains defined, hampering development more tailored therapeutic interventions. initiate or maintain This study demonstrates that MDE, showing cells; meanwhile, an phenotype. provides valuable insights into lymphocyte response, should lead advances therapeutics mood disorders.

Язык: Английский

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Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A Comprehensive Review

Biomolecules, Год журнала: 2025, Номер 15(4), С. 502 - 502

Опубликована: Март 30, 2025

Depression is a multifactorial psychiatric condition with complex pathophysiology, increasingly linked to neuroinflammatory processes. The present review explores the role of neuroinflammation in depression, focusing on glial cell activation, cytokine signaling, blood–brain barrier dysfunction, and disruptions neurotransmitter systems. article highlights how inflammatory mediators influence brain regions implicated mood regulation, such as hippocampus, amygdala, prefrontal cortex. further discusses involvement hypothalamic–pituitary–adrenal (HPA) axis, oxidative stress, kynurenine pathway, providing mechanistic insights into chronic inflammation may underlie emotional cognitive symptoms depression. bidirectional relationship between depressive emphasized, along peripheral immune responses systemic stress. By integrating molecular, cellular, neuroendocrine perspectives, this supports growing field immunopsychiatry lays foundation for novel diagnostic biomarkers anti-inflammatory treatment approaches Further research holds promise developing more effective personalized interventions individuals suffering from

Язык: Английский

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Hematological and biochemical markers and cytokine levels in hospitalized psychiatric patients with COVID-19

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 11, 2025

Background Multiple lines of evidence indicate a connection between the pathogenesis coronavirus disease 2019 (COVID-19) and psychiatric diseases (PDs). To improve treatment management individuals with psychosis COVID-19, we evaluated biomarkers PD patients, including those schizophrenia (SCZ), bipolar disorder (BD), major depression (MDD), along COVID-19. Methods In this study, 104 inpatients concurrent COVID-19 (PD+), same patients after they had recovered from (PD-), 97 healthy controls (HCs) were evaluated. We analyzed peripheral blood hematological parameters, serum biochemical cytokine levels participants compared results among three groups. Results The monocyte count; neutrophil-to-lymphocyte ratio (NLR); monocyte-to-lymphocyte (MLR); systemic immune-inflammation index (SII); C-reactive protein (CRP), CK isoenzyme MB (CK-MB), glucose (GLU), interleukin (IL)-6 significantly greater ( P &lt; 0.05), whereas magnesium (Mg) level was lower 0.05) in both PD+ PD- groups than HC group. Moreover, above indicators different 0.05). Conclusion Neutrophil count, NLR, MLR, SII, CRP, CK-MB, GLU IL-6 positively correlated PD. Mg negatively Our findings suggest that supplementation might be considered potential approach for Despite these insights, underlying pathophysiological mechanisms remain unclear, highlighting vital need further research to validate build upon findings.

Язык: Английский

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Immunological alterations in patients with current and lifetime suicide ideation and attempts: Examining the relationship with depressive symptoms

Brain Behavior & Immunity - Health, Год журнала: 2024, Номер 38, С. 100777 - 100777

Опубликована: Апрель 25, 2024

Suicidal ideation and attempt (SI/SA) have been associated with dysregulation of the immune response inflammation. However, few studies explored how innate acquired cellular immunity impact on peripheral response. Our study addresses this gap by examining composition cells humoral markers among individuals current SI/SA, a history healthy controls (HC). Additionally, we aim to explore whether depressive symptoms settle relationship between inflammation SI/SA. This is multicenter case-control that included 105 participants. Clinical demographic characterists together hemogram parameters, soluble pro anti- inflamatory factors, specific adaptive cell populations were compared patients SI/SA (n = 21), lifetime 42), HC 42). Patients both had significant increase in absolute count monocytes monocyte/lymphocyte ratio (MLR). showed hs-CRP, also higher levels ERS. The inflammatory status was characterized altered proportions nonclassical intermediate monocytes. No differences observed number lymphocytes proportion CD4 CD8 HC, but found exhaustion lymphocyte, increased PD1+ Current LAG3+ Lifetime HC. plasma marked sTREM2 Finally, multinomial analysis indicates are independently highlights association immunological alterations Furthremore, influenced may important therapeutic implications, as these patients, it be necessary treat process beyond treating symptoms.

Язык: Английский

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Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression and postpartum autoimmune thyroid disease

Expert Review of Clinical Immunology, Год журнала: 2024, Номер unknown, С. 1 - 23

Опубликована: Окт. 23, 2024

Introduction Postpartum mood disorders are heterogenous and comprise postpartum psychosis depression. Evidence is accumulating that systemic monocyte/macrophage activation, low grade inflammation (premature senescence related) T cell defects increase the risk for outside pregnancy by affecting function of microglia cells in emotional brain (the cortico-limbic system) leading to inadequate regulation upon stress.

Язык: Английский

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Peripheral CD4+ T helper lymphocytes alterations in major depressive disorder: A systematic review and meta-analysis

Neuroscience, Год журнала: 2024, Номер 555, С. 145 - 155

Опубликована: Июль 26, 2024

Язык: Английский

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Associations between Blood Cell Indices and Depression Risk: Insights from Multi-Cohort Analyses in UK Biobank and Mendelian Randomization

Опубликована: Янв. 1, 2024

Язык: Английский

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