Опубликована: Янв. 1, 2024
Язык: Английский
Redox Biology, Год журнала: 2024, Номер 75, С. 103249 - 103249
Опубликована: Июнь 19, 2024
Tumors develop in an oxidative environment characterized by peroxynitrite production and downstream protein tyrosine (Y) nitration. We showed that nitration supports schwannoma cell proliferation regulates metabolism the inheritable tumor disorder NF2-related Schwannomatosis (NF2-SWN). Here, we identified chaperone Heat shock 90 (Hsp90) as first nitrated acts a metabolic switch to promote proliferation. Doubling endogenous levels of Hsp90 cells or supplementing into normal Schwann increased their Metabolically, on either Y33 Y56 conferred distinct functions; at (Hsp90
Язык: Английский
Процитировано
3
Antioxidants, Год журнала: 2025, Номер 14(2), С. 211 - 211
Опубликована: Фев. 12, 2025
Mitochondrial diseases are complex disorders caused by nuclear or mitochondrial DNA mutations, leading to oxidative phosphorylation deficiency and excessive production of reactive oxygen species (ROS). While ROS have been well established in the pathogenesis these diseases, role nitrogen (RNS) remains unclear. In this study, we performed a quantitative analysis muscle fibers investigate relationship between protein nitration abnormalities (mitochondrial proliferation cytochrome-c oxidase (COX) deficiency) factors like genotype, damage, age. A total 1961 (303 from 4 controls 1658 29 patients with diseases) were analyzed immunostaining for nitro-tyrosine. Contrary previous findings, which identified nitro-tyrosine only small vessels, observed broader distribution affecting sarcolemma sarcoplasm. Using multivariate techniques, significant correlation but found no associations COX deficiency, age, genotype. These findings suggest that nitrative stress may contribute dysfunction play signaling processes induce biogenesis. Our results provide new insights into molecular mechanisms highlight potential relevance nitration.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1910 - 1910
Опубликована: Фев. 23, 2025
Reductive stress (RS), characterized by excessive accumulation of reducing equivalents such as NADH and NADPH, is emerging a key factor in metabolic disorders cancer. While oxidative (OS) has been widely studied, RS its complex interplay with endocrine regulation remain less understood. This review explores molecular circuits bidirectional crosstalk between hormones RS, focusing on their role diabetes, obesity, cardiovascular diseases, disrupts insulin secretion signaling, exacerbates inflammation, contributes to adipose tissue dysfunction, ultimately promoting resistance. In alters vascular smooth muscle cell function myocardial metabolism, influencing ischemia-reperfusion injury outcomes. cancer, plays dual role: it enhances tumor survival buffering OS reprogramming, yet can trigger proteotoxicity mitochondrial leading apoptosis. Recent studies have identified RS-targeting strategies, including redox-modulating therapies, nanomedicine, drug repurposing, offering potential for novel treatments. However, challenges remain, particularly distinguishing physiological from pathological conditions overcoming therapy-induced Future research should focus developing selective biomarkers, optimizing therapeutic interventions, exploring the immune regulation.
Язык: Английский
Процитировано
0
Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141700 - 141700
Опубликована: Март 3, 2025
Язык: Английский
Процитировано
0
The Chemical Record, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
Abstract Mimicking natural systems, self‐assembly has been employed for constructing highly stable and well‐ordered supramolecular structures. Amino acids are frequently used as building blocks in the process due to their advantageous characteristics including easy availability, functionalization, tunable mechanical property, biodegradability. In situ generation of active obtain complex materials via enhanced application biomedical fields bio‐imaging, therapeutics. Single amino acid small building‐block can provide artificial with unique properties. this review, we summarize tyrosine‐derivatives single acid‐based providing assemblies perspectives on potential impact. Finally, discuss ongoing challenges future research.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113732 - 113732
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Chemical Communications, Год журнала: 2023, Номер 59(77), С. 11484 - 11499
Опубликована: Янв. 1, 2023
This feature article discusses mass spectrometry-based strategies for the characterisation, localisation and differentiation of phosphorylation sulfation on proteins, considers future directions in field.
Язык: Английский
Процитировано
8
Redox Biochemistry and Chemistry, Год журнала: 2024, Номер 7, С. 100020 - 100020
Опубликована: Март 23, 2024
Nitrogen dioxide (•NO2) is a radical gas that forms part of air pollution and produced chemically, photochemically by ionizing radiation in aqueous non-aqueous solutions as well various endogenous pathways biological systems. This review describes the: (i) sources •NO2; (ii) kinetics mechanism •NO2 reactions; (iii) key player cellular oxidative nitrosative stress leading to pathological conditions, (iv) use diverse antioxidants reduce toxic effects.
Язык: Английский
Процитировано
3
Heliyon, Год журнала: 2024, Номер 10(15), С. e35374 - e35374
Опубликована: Июль 27, 2024
Increased osteoclast activity constitutes the primary etiology of excessive bone erosion in postmenopausal osteoporosis. ERp57, otherwise referred to as protein disulfide isomerase A3 (PDIA3), plays a crucial role regulation intracellular calcium signaling. This is documented exert profound impact on differentiation and functionality.
Язык: Английский
Процитировано
3