Oxidation products of proteins in plasma of newborns reflect damage inflicted by O2 supplementation and correlate with gestational age

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Impact of tyrosine amination on the aggregation and neurotoxicity of amyloid-β

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141700 - 141700

Published: March 3, 2025

Language: Английский

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Self‐assembly of Tyrosine Scaffolds in Aqueous Media: Complex Molecular Architectures from Simple Building Blocks

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Mimicking natural systems, self‐assembly has been employed for constructing highly stable and well‐ordered supramolecular structures. Amino acids are frequently used as building blocks in the process due to their advantageous characteristics including easy availability, functionalization, tunable mechanical property, biodegradability. In situ generation of active obtain complex materials via enhanced application biomedical fields bio‐imaging, therapeutics. Single amino acid small building‐block can provide artificial with unique properties. this review, we summarize tyrosine‐derivatives single acid‐based providing assemblies perspectives on potential impact. Finally, discuss ongoing challenges future research.

Language: Английский

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FS536, a novel nitric oxide-releasing doxorubicin hybrid, reverts multidrug resistance in lung cancer cells

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113732 - 113732

Published: April 1, 2025

Language: Английский

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Selective nitration of Hsp90 acts as a metabolic switch promoting tumor cell proliferation

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103249 - 103249

Published: June 19, 2024

Tumors develop in an oxidative environment characterized by peroxynitrite production and downstream protein tyrosine (Y) nitration. We showed that nitration supports schwannoma cell proliferation regulates metabolism the inheritable tumor disorder NF2-related Schwannomatosis (NF2-SWN). Here, we identified chaperone Heat shock 90 (Hsp90) as first nitrated acts a metabolic switch to promote proliferation. Doubling endogenous levels of Hsp90 cells or supplementing into normal Schwann increased their Metabolically, on either Y33 Y56 conferred distinct functions; at (Hsp90

Language: Английский

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Suppressing ERp57 diminishes osteoclast activity and ameliorates ovariectomy-induced bone loss via the intervention in calcium oscillation and the calmodulin/calcineurin/Nfatc1 pathway

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35374 - e35374

Published: July 27, 2024

Increased osteoclast activity constitutes the primary etiology of excessive bone erosion in postmenopausal osteoporosis. ERp57, otherwise referred to as protein disulfide isomerase A3 (PDIA3), plays a crucial role regulation intracellular calcium signaling. This is documented exert profound impact on differentiation and functionality.

Language: Английский

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Peroxynitrite: A tale of two radicals

Redox Biochemistry and Chemistry, Journal Year: 2024, Volume and Issue: 10, P. 100038 - 100038

Published: Aug. 3, 2024

The published syntheses of peroxynitrite from azide, nitrite, amylnitrite, hydroxylamine, nitrogen monoxide, and ammonia are discussed. With one exception, all these yield contaminated with nitrate nitrite as well reactants. rate constant for the reaction monoxide superoxide has been determined by pulse radiolysis flash photolysis. In studies, formation reactants may be rate-limiting could lead to underestimation second-order constant. conditions photolysis experiments can chosen minimize conflict between reactant half-life, thus 1.6 × 1010 M−1s−1 is preferred. toxicity attributed mainly its rapid carbon dioxide oxidizing trioxidocarbonate(•1−) radicals.

Language: Английский

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Considerations for defining +80 Da mass shifts in mass spectrometry-based proteomics: phosphorylation and beyond

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(77), P. 11484 - 11499

Published: Jan. 1, 2023

This feature article discusses mass spectrometry-based strategies for the characterisation, localisation and differentiation of phosphorylation sulfation on proteins, considers future directions in field.

Language: Английский

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Chemistry of nitrogen dioxide and its biological implications

Redox Biochemistry and Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 100020 - 100020

Published: March 23, 2024

Nitrogen dioxide (•NO2) is a radical gas that forms part of air pollution and produced chemically, photochemically by ionizing radiation in aqueous non-aqueous solutions as well various endogenous pathways biological systems. This review describes the: (i) sources •NO2; (ii) kinetics mechanism •NO2 reactions; (iii) key player cellular oxidative nitrosative stress leading to pathological conditions, (iv) use diverse antioxidants reduce toxic effects.

Language: Английский

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Protein tyrosine nitration

Redox Biochemistry and Chemistry, Journal Year: 2024, Volume and Issue: 8, P. 100030 - 100030

Published: May 31, 2024

Protein tyrosine nitration is a post-translational modification originating from the biological chemistry of nitric oxide. This article highlights key milestones, discusses apparent controversies and perspectives that have emerged in last 35 years research on protein nitration. Since execution oxide signaling accomplished entirely by post translational modifications (PTMs), prospect augments remains an intriguing but incomplete concept deserving further consideration.

Language: Английский

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