Bioengineering of the Optimized Biosynthesis of Commercially Vital Carotenoids- Techno-Advanced Applications DOI Creative Commons
Ishrat Perveen,

Naaz Abbas,

Bakhtawar Bukhari

и другие.

Pakistan BioMedical Journal, Год журнала: 2023, Номер unknown, С. 19 - 31

Опубликована: Дек. 31, 2023

Beta-carotene, a carotenoid found in plants, fungi, and algae, is crucial antioxidant anti-cancer agent. It primarily derived from microbes, but this method has drawbacks like high costs low productivity. The growing demand for carotenoids led to large-scale industrial manufacturing. However, extracting synthesizing these chemicals can be costly technical. Microbial synthesis offers cost-effective alternative. Synthetic biology metabolic engineering technologies have been used various studies the optimization of pathways overproduction carotenoids. Four components are involved biosynthesis, central carbon (C), isoprene supplement, cofactor metabolism. Metabolic potential solution enhance β-carotene production. This article explores biochemical routes, methods by natural microbial species, organisms β-carotenoids Currently, Escherichia coli, certain euglena yeast species primary microorganisms engineering, offering minimal environmental impact, manufacturing, yield.

Язык: Английский

Metabolic engineering for compartmentalized biosynthesis of the valuable compounds in Saccharomyces cerevisiae DOI

Mengqi Yin,

Kang Xu, Tao Luan

и другие.

Microbiological Research, Год журнала: 2024, Номер 286, С. 127815 - 127815

Опубликована: Июнь 26, 2024

Язык: Английский

Процитировано

9
Harnessing organelle engineering to facilitate biofuels and biochemicals production in yeast DOI
Phuong Hoang Tran, Taek Soon Lee

The Journal of Microbiology, Год журнала: 2025, Номер 63(3), С. e2501006 - e2501006

Опубликована: Март 28, 2025

Язык: Английский

Процитировано

1
Synthetic Engineering of Microbes for Production of Terpenoid Food Ingredients DOI
Bingyin Peng, Wei Shan

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 20, 2025

Terpenoids are a class of chemicals comprising many food ingredient chemicals. Synthetic biology and metabolic engineering have been performed to produce microbial cell factories for their production. For improved production various terpenoid ingredients, heterologous synthetic pathways can be optimized at multiple dimensions. Optimizing chassis precursor supply overcoming the host's inherent rigidity crucial enhancing overall efficiency Integrating regulatory circuits facilitate staged programming precise optimization endogenous metabolism. Engineering long-term genetic stability is essential successful scale-up commercial Maximizing in will rely on interdisciplinary tools advance state-of-the-art capabilities streamlined design construction complex genotypes chassis.

Язык: Английский

Процитировано

0
Construction of an orthogonal transport system for Saccharomyces cerevisiae peroxisome to efficiently produce sesquiterpenes DOI
Chuanbo Zhang, Chen Chen,

Xueke Bian

и другие.

Metabolic Engineering, Год журнала: 2024, Номер 85, С. 84 - 93

Опубликована: Июль 22, 2024

Язык: Английский

Процитировано

1
Bioengineering of the Optimized Biosynthesis of Commercially Vital Carotenoids- Techno-Advanced Applications DOI Creative Commons
Ishrat Perveen,

Naaz Abbas,

Bakhtawar Bukhari

и другие.

Pakistan BioMedical Journal, Год журнала: 2023, Номер unknown, С. 19 - 31

Опубликована: Дек. 31, 2023

Beta-carotene, a carotenoid found in plants, fungi, and algae, is crucial antioxidant anti-cancer agent. It primarily derived from microbes, but this method has drawbacks like high costs low productivity. The growing demand for carotenoids led to large-scale industrial manufacturing. However, extracting synthesizing these chemicals can be costly technical. Microbial synthesis offers cost-effective alternative. Synthetic biology metabolic engineering technologies have been used various studies the optimization of pathways overproduction carotenoids. Four components are involved biosynthesis, central carbon (C), isoprene supplement, cofactor metabolism. Metabolic potential solution enhance β-carotene production. This article explores biochemical routes, methods by natural microbial species, organisms β-carotenoids Currently, Escherichia coli, certain euglena yeast species primary microorganisms engineering, offering minimal environmental impact, manufacturing, yield.

Язык: Английский

Процитировано

0