Direct Access to α,β‐Unsaturated γ‐Lactams via Palladium‐Catalysed Carbonylation of Propargylic Ureas DOI Creative Commons

Debora Schiroli,

Aleksandr Voronov, Francesco Pancrazzi

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Additive carbonylations typically necessitate strong nucleophiles, such as alcohols or amines. In this study, we carbonylated a poorly nucleophilic urea, under oxidant‐free conditions. Our straightforward carbonylative strategy enables access to versatile α,β‐unsaturated γ‐lactams featuring an aminocarbonyl fragment, utilizing readily available propargylic ureas starting materials. The employment of the PdI 2 /KI catalytic system allowed complete regioselectivity ( 5‐endo‐dig ), high functional group tolerance, broad substrate scope well operational simplicity (oxidant‐free, organic ligand‐free and base‐free protocol). synthetic utility these is showcased through late‐stage functionalizations, Giese reactions peptide couplings.

Язык: Английский

Palladium-catalyzed selective alkoxycarbonylation of different alcohols toward the direct synthesis of cyclobutanecarboxylates DOI
Yukun Liu,

Xing‐Wei Gu,

Yanhua Zhao

и другие.

Journal of Catalysis, Год журнала: 2025, Номер unknown, С. 115956 - 115956

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Highly selective and additive-free Pd(OAc)2/CPP catalyzed hydroaminocarbonylation of alkynes DOI

Chenghui Dai,

Yan Chen, Jiaqi Xu

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(27), С. 5534 - 5539

Опубликована: Янв. 1, 2024

Herein, the synthesis of branched α,β-unsaturated amides by a hydroaminocarbonylation reaction alkynes with various amine substrates such as aromatic amines, aliphatic solid sources like NH

Язык: Английский

Процитировано

3
New Cinnamic Acid Sugar Esters as Potential UVB Filters: Synthesis, Cytotoxicity, and Physicochemical Properties DOI Creative Commons
Diego Olivieri, Michele Verboni, Serena Benedetti

и другие.

Carbohydrate Research, Год журнала: 2025, Номер unknown, С. 109405 - 109405

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Synthesis of NaLTA zeolite confined CuO catalysts and superior catalytic properties for alkene epoxidation with H2O2 as oxidant DOI
Xiaojing Song, Libin Yang,

Xinyu Chang

и другие.

Inorganic Chemistry Communications, Год журнала: 2024, Номер 170, С. 113453 - 113453

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

2
Direct Access to α,β‐Unsaturated γ‐Lactams via Palladium‐Catalysed Carbonylation of Propargylic Ureas DOI Creative Commons

Debora Schiroli,

Aleksandr Voronov, Francesco Pancrazzi

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Additive carbonylations typically necessitate strong nucleophiles, such as alcohols or amines. In this study, we carbonylated a poorly nucleophilic urea, under oxidant‐free conditions. Our straightforward carbonylative strategy enables access to versatile α,β‐unsaturated γ‐lactams featuring an aminocarbonyl fragment, utilizing readily available propargylic ureas starting materials. The employment of the PdI 2 /KI catalytic system allowed complete regioselectivity ( 5‐endo‐dig ), high functional group tolerance, broad substrate scope well operational simplicity (oxidant‐free, organic ligand‐free and base‐free protocol). synthetic utility these is showcased through late‐stage functionalizations, Giese reactions peptide couplings.

Язык: Английский

Процитировано

1