Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

A palladium-catalyzed alkoxycarbonylation with two different alcohols for the synthesis of cyclobutanecarboxylates bearing an α-quaternary carbon center is presented. The reaction utilizes readily accessible starting materials, tolerates a broad scope functional groups, and provides straightforward efficient approach diverse array carbon. Meanwhile, this strategy effectively prevents transition-metal-catalyzed ring-opening cyclobutanols, preserves cyclobutane framework, affords 1,1-disubstituted in high yields excellent regioisomeric ratios.

Язык: Английский