Palladium-Catalyzed Alkoxycarbonylation of Alcohols for the Synthesis of Cyclobutanecarboxylates with α-Quaternary Carbon Centers DOI
Yukun Liu,

Xing-Wei Gu,

Xiao‐Feng Wu

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

A palladium-catalyzed alkoxycarbonylation with two different alcohols for the synthesis of cyclobutanecarboxylates bearing an α-quaternary carbon center is presented. The reaction utilizes readily accessible starting materials, tolerates a broad scope functional groups, and provides straightforward efficient approach diverse array carbon. Meanwhile, this strategy effectively prevents transition-metal-catalyzed ring-opening cyclobutanols, preserves cyclobutane framework, affords 1,1-disubstituted in high yields excellent regioisomeric ratios.

Language: Английский

Palladium-Catalyzed Alkoxycarbonylation of Alcohols for the Synthesis of Cyclobutanecarboxylates with α-Quaternary Carbon Centers DOI
Yukun Liu,

Xing-Wei Gu,

Xiao‐Feng Wu

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

A palladium-catalyzed alkoxycarbonylation with two different alcohols for the synthesis of cyclobutanecarboxylates bearing an α-quaternary carbon center is presented. The reaction utilizes readily accessible starting materials, tolerates a broad scope functional groups, and provides straightforward efficient approach diverse array carbon. Meanwhile, this strategy effectively prevents transition-metal-catalyzed ring-opening cyclobutanols, preserves cyclobutane framework, affords 1,1-disubstituted in high yields excellent regioisomeric ratios.

Language: Английский

Citations

0