Nanotechnology,
Год журнала:
2024,
Номер
36(4), С. 045101 - 045101
Опубликована: Окт. 30, 2024
Abstract
The
tumor
microenvironment
(TME)
is
characterized
by
low
pH,
hypoxia,
and
overexpression
of
glutathione
(GSH).
Owing
to
the
complexity
pathogenesis
heterogeneity
TME,
achieving
satisfactory
efficacy
with
a
single
treatment
method
difficult,
which
significantly
impedes
treatment.
In
this
study,
composite
nanoparticles
calcium-copper/alginate-hyaluronic
acid
(HA)
(CaO
2
-CuO
@SA/HA
NC)
pH
GSH
responsiveness
were
prepared
for
first
time
through
one-step
synthesis
using
HA
as
targeting
ligand.
Nanoparticles
loaded
H
O
can
enhance
chemodynamic
therapy
effects.
Simultaneously,
Cu
2+
generate
oxygen
in
TME
alleviate
hypoxia
tissue.
undergo
Fenton
reaction
produce
cytotoxic
hydroxyl
radicals
Ca
ions,
localization
clearance
cells.
Additionally,
sodium
alginate
(SA)
utilized
improve
biocompatibility
nanoparticles.
Fourier
transform
infrared,
x-ray
diffraction,
dynamic
light
scattering,
SEM,
transmission
electron
microscope,
other
analytical
methods
used
investigate
their
physical
chemical
properties.
results
indicate
that
CaO
NC
had
particle
size
220
nm,
narrow
distribution,
uniform
morphology.
hydrogen
peroxide
self-supplied
nanodrug
delivery
system
exhibited
excellent
pH-responsive
release
performance
glutathione-responsive
•OH
ability
while
also
reducing
level
reactive
oxide
species
quenching.
vitro
cell
experiments,
no
obvious
side
effects
on
normal
tissues
observed;
however,
inhibition
rate
malignant
tumors
HepG2
DU145
exceeded
50%.
preparation
nanoparticles,
achieve
both
chemokinetic
ion
interference
therapy,
has
demonstrated
significant
potential
clinical
applications
cancer
therapy.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(7), С. 2515 - 2525
Опубликована: Май 23, 2024
Tumor-associated
macrophages
(TAMs)
account
for
30%–50%
of
tumor
tissue
and
are
involved
in
tumorigenesis,
progression,
invasion,
metastasis.
Thus,
cells
no
longer
the
only
target
therapy.
Here,
we
proposed
a
strategy
"one-stone-two-birds"
by
targeting
M2
TAMs
simultaneously
with
ion
interference
therapy
(IIT)
synergistic
chemodynamic
(CDT)
via
nanoplatform
(CZPM).
The
CZPM
was
prepared
employing
CuNCs
as
source
light
Fenton
metal,
encapsulated
ZIF-8
IIT,
finally
modified
mannose.
obtained
could
enhance
cellular
uptake
CT26
respond
to
cleavage
acidic
environment
endosomes
lysosomes,
releasing
Zn2+
IIT
synergistically
enhancing
CDT.
In
vitro
vivo
experiments
confirmed
that
showed
significant
therapeutic
effects.
conclusion,
an
effective
dual-targeting
dual-therapeutic
has
been
developed
based
on
nanoplatform.
Nanotechnology,
Год журнала:
2024,
Номер
36(4), С. 045101 - 045101
Опубликована: Окт. 30, 2024
Abstract
The
tumor
microenvironment
(TME)
is
characterized
by
low
pH,
hypoxia,
and
overexpression
of
glutathione
(GSH).
Owing
to
the
complexity
pathogenesis
heterogeneity
TME,
achieving
satisfactory
efficacy
with
a
single
treatment
method
difficult,
which
significantly
impedes
treatment.
In
this
study,
composite
nanoparticles
calcium-copper/alginate-hyaluronic
acid
(HA)
(CaO
2
-CuO
@SA/HA
NC)
pH
GSH
responsiveness
were
prepared
for
first
time
through
one-step
synthesis
using
HA
as
targeting
ligand.
Nanoparticles
loaded
H
O
can
enhance
chemodynamic
therapy
effects.
Simultaneously,
Cu
2+
generate
oxygen
in
TME
alleviate
hypoxia
tissue.
undergo
Fenton
reaction
produce
cytotoxic
hydroxyl
radicals
Ca
ions,
localization
clearance
cells.
Additionally,
sodium
alginate
(SA)
utilized
improve
biocompatibility
nanoparticles.
Fourier
transform
infrared,
x-ray
diffraction,
dynamic
light
scattering,
SEM,
transmission
electron
microscope,
other
analytical
methods
used
investigate
their
physical
chemical
properties.
results
indicate
that
CaO
NC
had
particle
size
220
nm,
narrow
distribution,
uniform
morphology.
hydrogen
peroxide
self-supplied
nanodrug
delivery
system
exhibited
excellent
pH-responsive
release
performance
glutathione-responsive
•OH
ability
while
also
reducing
level
reactive
oxide
species
quenching.
vitro
cell
experiments,
no
obvious
side
effects
on
normal
tissues
observed;
however,
inhibition
rate
malignant
tumors
HepG2
DU145
exceeded
50%.
preparation
nanoparticles,
achieve
both
chemokinetic
ion
interference
therapy,
has
demonstrated
significant
potential
clinical
applications
cancer
therapy.
