Cytotoxicity of ZIF-8@APTES-MS on murine melanoma cells

Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(9), P. 3959 - 3969

Published: Feb. 26, 2024

Language: Английский

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CuNCs-Based pH-Responsive Degradable Nanoplatform for Enhanced CDT/IIT Synergistic Tumor Therapy in a “One-Stone-Two-Birds” Manner

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2515 - 2525

Published: May 23, 2024

Tumor-associated macrophages (TAMs) account for 30%–50% of tumor tissue and are involved in tumorigenesis, progression, invasion, metastasis. Thus, cells no longer the only target therapy. Here, we proposed a strategy "one-stone-two-birds" by targeting M2 TAMs simultaneously with ion interference therapy (IIT) synergistic chemodynamic (CDT) via nanoplatform (CZPM). The CZPM was prepared employing CuNCs as source light Fenton metal, encapsulated ZIF-8 IIT, finally modified mannose. obtained could enhance cellular uptake CT26 respond to cleavage acidic environment endosomes lysosomes, releasing Zn2+ IIT synergistically enhancing CDT. In vitro vivo experiments confirmed that showed significant therapeutic effects. conclusion, an effective dual-targeting dual-therapeutic has been developed based on nanoplatform.

Language: Английский

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Co-delivery of vitamin and amino acid within MOFs for oxidative stress-based tumor gas therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 518 - 528

Published: Nov. 19, 2024

Language: Английский

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Self-supply of hydrogen peroxide by a bimetal-based nanocatalytic platform to enhance chemodynamic therapy for tumor treatment

Nanotechnology, Journal Year: 2024, Volume and Issue: 36(4), P. 045101 - 045101

Published: Oct. 30, 2024

Abstract The tumor microenvironment (TME) is characterized by low pH, hypoxia, and overexpression of glutathione (GSH). Owing to the complexity pathogenesis heterogeneity TME, achieving satisfactory efficacy with a single treatment method difficult, which significantly impedes treatment. In this study, composite nanoparticles calcium-copper/alginate-hyaluronic acid (HA) (CaO 2 -CuO @SA/HA NC) pH GSH responsiveness were prepared for first time through one-step synthesis using HA as targeting ligand. Nanoparticles loaded H O can enhance chemodynamic therapy effects. Simultaneously, Cu 2+ generate oxygen in TME alleviate hypoxia tissue. undergo Fenton reaction produce cytotoxic hydroxyl radicals Ca ions, localization clearance cells. Additionally, sodium alginate (SA) utilized improve biocompatibility nanoparticles. Fourier transform infrared, x-ray diffraction, dynamic light scattering, SEM, transmission electron microscope, other analytical methods used investigate their physical chemical properties. results indicate that CaO NC had particle size 220 nm, narrow distribution, uniform morphology. hydrogen peroxide self-supplied nanodrug delivery system exhibited excellent pH-responsive release performance glutathione-responsive •OH ability while also reducing level reactive oxide species quenching. vitro cell experiments, no obvious side effects on normal tissues observed; however, inhibition rate malignant tumors HepG2 DU145 exceeded 50%. preparation nanoparticles, achieve both chemokinetic ion interference therapy, has demonstrated significant potential clinical applications cancer therapy.

Language: Английский

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pH-responsive chiral supramolecular cysteine-Zn2+-indocyanine green assemblies for triple-level chirality-specific anti-tumor efficacy

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110432 - 110432

Published: Sept. 1, 2024

Language: Английский

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