Optics Express,
Год журнала:
2024,
Номер
32(10), С. 17464 - 17464
Опубликована: Апрель 11, 2024
Microwave-induced
thermoacoustic
(TA)
imaging
(MTAI)
combines
pulsed
microwave
excitation
and
ultrasound
detection
to
provide
high
contrast
spatial
resolution
images
through
dielectric
contrast,
which
holds
great
promise
for
clinical
applications.
However,
artifacts
caused
by
effect
will
seriously
affect
the
accuracy
of
MTAI
that
hinder
translation
MTAI.
In
this
work,
we
propose
a
deep
learning-based
method
fully
dense
generative
adversarial
network
(FD-GAN)
removing
in
FD-GAN
adds
block
(GAN)
based
on
mutual
confrontation
between
generator
discriminator,
enables
it
learn
both
local
global
features
related
removal
generate
high-quality
images.
The
practical
feasibility
was
tested
simulated,
experimental
data.
results
demonstrate
can
effectively
remove
effect,
shows
superiority
denoising,
background
suppression,
improvement
image
distortion.
Our
approach
is
expected
significantly
improve
quality
images,
thereby
enhancing
diagnostic
innovative
technique.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 3, 2024
Abstract
Although
conventional
therapeutic
approaches
demonstrate
significant
success
in
treating
primary
tumors,
their
efficacy
diminishes
when
addressing
distant
and
metastatic
calling
for
new
technologies
to
transport
activate
the
agents.
Here,
a
core‐shell
UCNP@MOF
(upconversion
nanoparticle
—
metal
organic
framework)
nanoagents
is
constructed
Type
I
II
photodynamic
therapy
under
biocompatible
near‐infrared
light
irradiance
(at
808
nm)
utilize
pore
loading
capacity
further
realize
synergistic
immunotherapy
solid
tumors.
The
Cu
2+
+
reduction
at
nodes
MOFs
shell
demonstrated
promote
generation
of
reactive
oxygen
species
via
depletion
overexpressed
glutathione
(GSH)
compounds,
while
tumor
microenvironment‐enriched
hydrogen
peroxide
found
substantially
augment
PDT
effects.
Importantly,
pore‐loaded
indoleamine
2,3‐dioxygenase
(IDO)
inhibitor,
along
with
s‐nitroso‐n‐acetylpenicillamine
(SNAP),
upregulated
tumor‐infiltrating
lymphocytes
induced
prominent
immunotherapeutic
effects
vivo.
This
have
effectiveness
against
both
tumors
xenografted
models,
holding
promise
metastasis.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3414 - 3414
Опубликована: Март 18, 2024
The
association
between
cancer
and
inflammation
is
well
established.
Chronic
represents
a
fundamental
step
in
the
development
progression
of
some
types
cancer.
Tumors
are
composed
heterogeneous
population
infiltrating
cells
including
macrophages,
fibroblasts,
lymphocytes,
granulocytes,
mast
cells,
which
respond
to
signals
from
microenvironment
and,
turn,
produce
cytokines,
chemokines,
transcription
factors,
receptors,
miRNAs.
Recent
data
demonstrate
that,
addition
classical
(M1)
alternative
(M2)
macrophage
subtypes,
there
many
intermediate
subtypes
that
potentially
play
different
roles
response
environmental
stimuli.
infiltrated
by
macrophages
called
TAMs
mainly
display
an
M2-like
phenotype
tumor
growth-permissive
activities.
There
bidirectional
interaction
tumor-infiltrating
determines
polarization
ultimately
or
regression.
These
complex
interactions
still
unclear
but
understanding
them
for
new
therapeutic
strategies.
Re-educating
tumor-permissive
into
anti-tumor
focus
research.
This
review
aims
analyze
most
recent
articles
investigating
interplay
tumors,
TAMs,
strategies
re-educating
macrophages.
Biomaterials Research,
Год журнала:
2024,
Номер
28
Опубликована: Янв. 1, 2024
It
is
urgent
to
develop
an
alternative
dynamic
therapy-based
method
overcome
the
limited
efficacy
of
traditional
therapy
methods
for
bladder
cancer
and
damage
caused
patients.
Sonodynamic
(SDT)
has
advantages
high
tissue
penetration,
spatiotemporal
selectivity,
being
non-invasive,
representing
emerging
eradicating
deep
solid
tumors.
However,
effectiveness
SDT
often
hindered
by
inefficient
production
reactive
oxygen
species
nondegradability
sonosensitizer.
To
improve
anti-tumor
effect
on
cancer,
herein,
a
BP-based
heterojunction
sonosensitizer
(BFeSe
2
)
was
synthesized
anchoring
FeSe
onto
BP
via
P–Se
bonding
enhance
stability
SDT.
As
result,
BFeSe
showed
great
cytotoxicity
cells
under
ultrasound
(US)
irradiation.
led
notable
inhibition
tumor
growth
in
subcutaneous
models
orthotopic
US
In
addition,
could
also
T2-weighted
magnetic
resonance
imaging
(MRI)
achieve
monitoring
guide
treatment
cancer.
general,
integrates
MRI
functions
precise
treatment,
promising
clinical
potential
theranostics
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(22)
Опубликована: Май 25, 2024
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disorder
characterized
by
joint
inflammation
and
destruction.
Current
treatments,
such
as
Methotrexate
(MTX),
though
effective,
often
face
limitations
high
plasma
C
Abstract
Rheumatoid
arthritis
(RA)
is
a
systemic
autoimmune
disorder
characterized
by
excessive
proliferation
of
rheumatoid
synovial
fibroblasts
(RASFs)
and
accumulation
inflammatory
cytokines.
Exploring
the
suppression
RASFs
modulation
RA
microenvironment
considered
comprehensive
strategy
for
RA.
In
this
work,
specifically
activated
nanoagents
(MAHI
NGs)
based
on
hypoxic
weakly
acidic
are
developed
to
achieve
second
near‐infrared
fluorescence
(NIR‐II
FL)/photoacoustic
(PA)
dual‐model
imaging‐guided
multi‐treatment.
Due
optimal
size,
MAHI
NGs
passively
accumulate
in
diseased
joint
region
undergo
rapid
responsive
degradation,
precisely
releasing
functionalized
components:
endogenous
melanin‐nanoparticles
(MNPs),
hydrogen
gas
(H
2
),
indocyanine
green
(ICG).
The
released
MNPs
play
crucial
role
ablating
within
through
photothermal
therapy
(PTT)
guided
accurate
PA
imaging.
However,
regional
hyperthermia
generated
PTT
may
exacerbate
reactive
oxygen
species
(ROS)
production
response
following
cell
lysis.
Remarkably,
under
microenvironment,
controlled
release
H
exhibits
precise
synergistic
antioxidant
anti‐inflammatory
effects
with
MNPs.
Moreover,
ICG,
dye
currently
approved
clinical
use,
possesses
excellent
NIR‐II
FL
imaging
properties
that
facilitate
diagnosis
deep
tissue
diseases
provide
right
time‐point
PTT.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 31, 2024
Precise
identification
of
glioblastoma
(GBM)
microinfiltration,
which
is
essential
for
achieving
complete
resection,
remains
an
enormous
challenge
in
clinical
practice.
Here,
the
study
demonstrates
that
Raman
spectroscopy
effectively
identifies
GBM
microinfiltration
with
cellular
resolution
specimens.
The
spectral
differences
between
infiltrative
lesions
and
normal
brain
tissues
are
attributed
to
phospholipids,
nucleic
acids,
amino
unsaturated
fatty
acids.
These
biochemical
metabolites
identified
by
further
confirmed
spatial
metabolomics.
Based
on
differential
spectra,
imaging
resolves
important
morphological
information
relevant
a
label-free
manner.
area
under
receiver
operating
characteristic
curve
(AUC)
combined
machine
learning
detecting
exceeds
95%.
Most
importantly,
cancer
cell
threshold
as
low
3
human
cells
per
0.01
mm
The
tumor
microenvironment
(TME)
plays
a
critical
role
in
cancer
progression
and
response
to
immunotherapy.
Immunotherapy
targeting
the
immune
system
has
emerged
as
promising
treatment
modality,
but
challenges
understanding
TME
limit
its
efficacy.
Optical
imaging
strategies
offer
noninvasive,
real-time
insights
into
interactions
between
cells
TME.
