Nanoscale Advances, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Recent focus on sustainable nanoparticle synthesis highlights bioinspired nano-antimicrobials advantages over chemically synthesized counterparts. This study pioneers the green of porphyrinic nanocubes, demonstrating potent antibacterial activity through sono-photodynamic inactivation. approach holds promise in combating antibiotic resistance.
Язык: Английский
Pharmaceutics, Год журнала: 2024, Номер 16(6), С. 822 - 822
Опубликована: Июнь 18, 2024
DOX/TPOR4@CB[7]4 was synthesized via self-assembly, and its physicochemical properties ability to generate reactive oxygen species (ROS) were evaluated. The impact of photodynamic therapy on SH-SY5Y cells assessed using the MTT assay, while flow cytometry analysis employed detect cell apoptosis. Confocal laser scanning microscopy utilized observe intracellular distribution in cells. Additionally, fluorescence imaging nude mice bearing tumors examination combined effects chemical therapies conducted. incorporation CB[7] significantly enhanced optical DOX/TPOR4@CB[7]4, resulting increased ROS production pronounced toxicity towards Moreover, both apoptotic mortality rates exhibited significant elevation. In vivo experiments demonstrated that tumor growth inhibition most prominent group. π–π interactions facilitated binding between DOX photosensitizer TPOR, with TPOR’s naphthalene hydrophilic groups encapsulated within CB[7]’s cavity through host–guest CB[7]. Therefore, can serve as a nanocarrier enhance application therapy, thereby improving treatment efficacy against neuroblastoma tumors.
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2024, Номер 29(20), С. 4828 - 4828
Опубликована: Окт. 11, 2024
Dynamic tumor therapies (mainly including photodynamic therapy (PDT) and sonodynamic (SDT)) offer new approaches to cancer treatment. They are often characterized by their noninvasive nature, high selectivity, low toxicity. Sensitizers crucial for dynamic therapy. Developing efficient sensitizers with good biocompatibility controllability is an important aim in Porphyrins metalloporphyrins attract great attention due excellent photophysical properties cytotoxicity under non-light. Compared porphyrins, show greater potential enhanced photochemical after metal ions coordinate porphyrin rings. This paper reviews some metalloporphyrin-based used photo/sonodynamic combined In addition, the probable challenges bottlenecks clinical translation also discussed.
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The common ways and various materials used for modulating electronic band structure SDT are summarized.
Язык: Английский
Процитировано
1
Nanoscale Advances, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Recent focus on sustainable nanoparticle synthesis highlights bioinspired nano-antimicrobials advantages over chemically synthesized counterparts. This study pioneers the green of porphyrinic nanocubes, demonstrating potent antibacterial activity through sono-photodynamic inactivation. approach holds promise in combating antibiotic resistance.
Язык: Английский
Процитировано
0