Recent advances of piezoelectric materials used in sonodynamic therapy of tumor
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
523, С. 216282 - 216282
Опубликована: Окт. 22, 2024
Язык: Английский
Low-Intensity Pulsed Ultrasound Responsive Scaffold Promotes Intramembranous and Endochondral Ossification via Ultrasonic, Thermal, and Electrical Stimulation
ACS Nano,
Год журнала:
2025,
Номер
19(4), С. 4422 - 4439
Опубликована: Янв. 21, 2025
Multiple
physical
stimuli
are
expected
to
produce
a
synergistic
effect
promote
bone
tissue
regeneration.
Low-intensity
pulsed
ultrasound
(LIPUS)
has
been
clinically
used
in
repair
for
the
mechanical
stimulation
that
it
provides.
In
addition,
LIPUS
can
also
excite
biomaterials
generate
other
such
as
thermal
or
electrical
stimuli.
this
study,
scaffold
based
on
decellularized
adipose
(DAT)
is
established
by
incorporating
polydopamine-modified
multilayer
black
phosphorus
nanosheets
(pDA-mBP@DAT).
Their
under
and
potential
mechanisms
further
investigated.
This
possesses
piezoelectric
properties
generates
mild
thermogenic
stimulus
when
stimulated
LIPUS.
With
superior
properties,
demonstrated
have
good
cytocompatibility
vitro
vivo.
Simultaneously,
promotes
cell
attachment,
migration,
osteogenic
differentiation
pDA-mBP@DAT
scaffold.
Furthermore,
combined
use
of
significantly
affects
regenerative
rat
models
critical-sized
calvarial
defects.
The
possible
include
promoting
osteogenesis
neovascularization
activating
Piezo1.
study
presents
insight
into
speeding
up
regeneration
combination
scaffolds.
Язык: Английский
Advances in Multimodal Synergistic Therapy Derived from Sonodynamic Therapy Mediated by BaTiO3 Piezoelectric Nanomaterials in Tumor Treatment
Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Tumors
endanger
the
lives
of
individuals
worldwide.
They
form
and
metastatize
to
nearby
distant
tissues
organs
in
several
ways,
which
greatly
increase
difficulty
therapy.
The
continuous
development
progress
nanomedicine
has
provided
new
insights
treatment
tumors.
Owing
their
excellent
properties
barium
titanate
(BaTiO
3
,
BTO),
especially
piezoelectricity,
BTO‐based
nanomaterials
have
become
popular
among
tumor
therapy
researchers
recent
years.
sonodynamic
(SDT)
is
considerably
advanced
than
traditional
therapies.
Herein,
first,
properties,
structure,
preparation
technology,
working
mechanism
BTO
under
ultrasonic
stimulation
systematically
introduced.
Second,
research
BTO‐mediated
SDT,
electrical
therapy,
SDT‐derived
multimodal
synergistic
field
reviewed.
Third,
biocompatibility,
biodistribution,
bioelimination
summarized.
Finally,
current
problems
associated
with
SDT
as
well
potential
obstacles
opportunities
oncology
other
biomedical
fields
are
summarized
prospected.
Язык: Английский
Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy
Inorganics,
Год журнала:
2025,
Номер
13(3), С. 71 - 71
Опубликована: Фев. 26, 2025
As
a
non-invasive
modality,
sonodynamic
therapy
(SDT)
offers
several
advantages
in
cancer
treatment,
including
deep
tissue
penetration
and
precise
spatiotemporal
control,
resulting
from
the
interplay
between
low-intensity
ultrasound
sonosensitizers.
Piezoelectric
materials,
known
for
their
remarkable
capacity
of
interconversion
mechanical
electrical
energy,
have
garnered
considerable
attention
biomedical
applications,
which
can
serve
as
pivotal
sonosensitizers
SDT.
These
materials
generate
internal
electric
fields
via
ultrasound-induced
deformation,
modulates
alteration
charge
carriers,
thereby
initiating
surface
redox
reactions
to
reactive
oxygen
species
(ROS)
realizing
therapeutic
efficacy
This
review
provides
an
in-depth
exploration
piezoelectric
utilized
SDT,
with
particular
emphasis
on
recent
innovations,
elucidation
underlying
mechanisms,
optimization
strategies
advanced
materials.
Furthermore,
incorporation
immunotherapy,
photodynamic,
chemodynamic,
chemotherapy
is
explored,
emphasizing
potential
enhance
outcomes.
By
examining
basic
principles
effect
its
contributions
this
sheds
light
promising
applications
oncology.
It
also
highlights
future
directions
improving
these
expanding
clinical
utility
tumor
therapy.
Язык: Английский
Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(4), С. 114 - 114
Опубликована: Март 24, 2025
Cancer
significantly
impacts
human
quality
of
life
and
expectancy,
with
an
estimated
20
million
new
cases
10
cancer-related
deaths
worldwide
every
year.
Standard
treatments
including
chemotherapy,
radiotherapy,
surgical
removal,
for
aggressive
cancers,
such
as
glioblastoma,
are
often
ineffective
in
late
stages.
Glioblastoma,
example,
is
known
its
poor
prognosis
post-diagnosis,
a
median
survival
time
approximately
15
months.
Novel
therapies
using
local
electric
fields
have
shown
anti-tumour
effects
glioblastoma
by
disrupting
mitotic
spindle
assembly
inhibiting
cell
growth.
However,
constant
application
poses
risks
like
patient
burns.
Wireless
stimulation
via
piezoelectric
nanomaterials
offers
safer
alternative,
requiring
ultrasound
activation
to
induce
therapeutic
effects,
altering
voltage-gated
ion
channel
conductance
depolarising
membrane
potentials.
This
review
highlights
the
mechanism,
drug
delivery,
activation,
current
technologies
cancer
therapy,
emphasising
need
further
research
address
limitations
biocompatibility
whole
systems.
The
goal
underscore
these
areas
inspire
avenues
overcome
barriers
developing
nanoparticle-based
therapies.
Язык: Английский