Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma DOI Creative Commons

Zayne Knight,

Amalia Ruiz, Jacobo Elíes

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(4), P. 114 - 114

Published: March 24, 2025

Cancer significantly impacts human quality of life and expectancy, with an estimated 20 million new cases 10 cancer-related deaths worldwide every year. Standard treatments including chemotherapy, radiotherapy, surgical removal, for aggressive cancers, such as glioblastoma, are often ineffective in late stages. Glioblastoma, example, is known its poor prognosis post-diagnosis, a median survival time approximately 15 months. Novel therapies using local electric fields have shown anti-tumour effects glioblastoma by disrupting mitotic spindle assembly inhibiting cell growth. However, constant application poses risks like patient burns. Wireless stimulation via piezoelectric nanomaterials offers safer alternative, requiring ultrasound activation to induce therapeutic effects, altering voltage-gated ion channel conductance depolarising membrane potentials. This review highlights the mechanism, drug delivery, activation, current technologies cancer therapy, emphasising need further research address limitations biocompatibility whole systems. The goal underscore these areas inspire avenues overcome barriers developing nanoparticle-based therapies.

Language: Английский

Recent advances of piezoelectric materials used in sonodynamic therapy of tumor DOI

Hsin-I Huang,

Yuqing Miao, Yuhao Li

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216282 - 216282

Published: Oct. 22, 2024

Language: Английский

Citations

7
Low-Intensity Pulsed Ultrasound Responsive Scaffold Promotes Intramembranous and Endochondral Ossification via Ultrasonic, Thermal, and Electrical Stimulation DOI

Wanru Jia,

Tianlong Wang, Feng Chen

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: 19(4), P. 4422 - 4439

Published: Jan. 21, 2025

Multiple physical stimuli are expected to produce a synergistic effect promote bone tissue regeneration. Low-intensity pulsed ultrasound (LIPUS) has been clinically used in repair for the mechanical stimulation that it provides. In addition, LIPUS can also excite biomaterials generate other such as thermal or electrical stimuli. this study, scaffold based on decellularized adipose (DAT) is established by incorporating polydopamine-modified multilayer black phosphorus nanosheets (pDA-mBP@DAT). Their under and potential mechanisms further investigated. This possesses piezoelectric properties generates mild thermogenic stimulus when stimulated LIPUS. With superior properties, demonstrated have good cytocompatibility vitro vivo. Simultaneously, promotes cell attachment, migration, osteogenic differentiation pDA-mBP@DAT scaffold. Furthermore, combined use of significantly affects regenerative rat models critical-sized calvarial defects. The possible include promoting osteogenesis neovascularization activating Piezo1. study presents insight into speeding up regeneration combination scaffolds.

Language: Английский

Citations

0
Advances in Multimodal Synergistic Therapy Derived from Sonodynamic Therapy Mediated by BaTiO3 Piezoelectric Nanomaterials in Tumor Treatment DOI Creative Commons

Yajuan Gong,

Qi Jin, Shuo Huang

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Tumors endanger the lives of individuals worldwide. They form and metastatize to nearby distant tissues organs in several ways, which greatly increase difficulty therapy. The continuous development progress nanomedicine has provided new insights treatment tumors. Owing their excellent properties barium titanate (BaTiO 3 , BTO), especially piezoelectricity, BTO‐based nanomaterials have become popular among tumor therapy researchers recent years. sonodynamic (SDT) is considerably advanced than traditional therapies. Herein, first, properties, structure, preparation technology, working mechanism BTO under ultrasonic stimulation systematically introduced. Second, research BTO‐mediated SDT, electrical therapy, SDT‐derived multimodal synergistic field reviewed. Third, biocompatibility, biodistribution, bioelimination summarized. Finally, current problems associated with SDT as well potential obstacles opportunities oncology other biomedical fields are summarized prospected.

Language: Английский

Citations

0
Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy DOI Creative Commons
Guiyun Wang,

Yanxia Qi,

Zhuang Liu

et al.

Inorganics, Journal Year: 2025, Volume and Issue: 13(3), P. 71 - 71

Published: Feb. 26, 2025

As a non-invasive modality, sonodynamic therapy (SDT) offers several advantages in cancer treatment, including deep tissue penetration and precise spatiotemporal control, resulting from the interplay between low-intensity ultrasound sonosensitizers. Piezoelectric materials, known for their remarkable capacity of interconversion mechanical electrical energy, have garnered considerable attention biomedical applications, which can serve as pivotal sonosensitizers SDT. These materials generate internal electric fields via ultrasound-induced deformation, modulates alteration charge carriers, thereby initiating surface redox reactions to reactive oxygen species (ROS) realizing therapeutic efficacy This review provides an in-depth exploration piezoelectric utilized SDT, with particular emphasis on recent innovations, elucidation underlying mechanisms, optimization strategies advanced materials. Furthermore, incorporation immunotherapy, photodynamic, chemodynamic, chemotherapy is explored, emphasizing potential enhance outcomes. By examining basic principles effect its contributions this sheds light promising applications oncology. It also highlights future directions improving these expanding clinical utility tumor therapy.

Language: Английский

Citations

0
Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma DOI Creative Commons

Zayne Knight,

Amalia Ruiz, Jacobo Elíes

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(4), P. 114 - 114

Published: March 24, 2025

Cancer significantly impacts human quality of life and expectancy, with an estimated 20 million new cases 10 cancer-related deaths worldwide every year. Standard treatments including chemotherapy, radiotherapy, surgical removal, for aggressive cancers, such as glioblastoma, are often ineffective in late stages. Glioblastoma, example, is known its poor prognosis post-diagnosis, a median survival time approximately 15 months. Novel therapies using local electric fields have shown anti-tumour effects glioblastoma by disrupting mitotic spindle assembly inhibiting cell growth. However, constant application poses risks like patient burns. Wireless stimulation via piezoelectric nanomaterials offers safer alternative, requiring ultrasound activation to induce therapeutic effects, altering voltage-gated ion channel conductance depolarising membrane potentials. This review highlights the mechanism, drug delivery, activation, current technologies cancer therapy, emphasising need further research address limitations biocompatibility whole systems. The goal underscore these areas inspire avenues overcome barriers developing nanoparticle-based therapies.

Language: Английский

Citations

0