Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1202 - 1202
Опубликована: Сен. 13, 2024
Gallic
acid
(GA)
is
a
well-known
herbal
bioactive
compound
found
in
many
herbs
and
foods
like
tea,
wine,
cashew
nuts,
hazelnuts,
walnuts,
plums,
grapes,
mangoes,
blackberries,
blueberries,
strawberries.
GA
has
been
reported
for
several
pharmacological
activities,
such
as
antioxidant,
inflammatory,
antineoplastic,
antimicrobial,
etc.
Apart
from
its
incredible
therapeutic
benefits,
it
associated
with
low
permeability
bioavailability
issues,
limiting
their
efficacy.
belongs
to
BCS
(Biopharmaceutics
classification
system)
class
III
(high
solubility
probability).
In
this
context,
novel
drug
delivery
approaches
played
vital
role
resolving
these
issues.
Nanocarrier
systems
help
improve
moiety’s
physical
chemical
stability
by
encapsulating
them
into
lipidic
or
polymeric
matrix
core
system.
regard,
researchers
have
developed
wide
range
of
nanocarrier
GA,
including
liposomes,
transfersomes,
niosomes,
dendrimers,
phytosomes,
micelles,
nanoemulsions,
metallic
nanoparticles,
solid
lipid
nanoparticles
(SLNs),
nanostructured
carriers,
polymer
conjugates,
the
present
review,
different
search
engines
Scopus,
PubMed,
ScienceDirect,
Google
Scholar
referred
acquiring
recent
information
on
theme
work.
Therefore,
review
paper
aims
emphasize
systems,
patents,
clinical
updates
GA.
Язык: Английский
Paclitaxel prodrug nanoparticles boost antitumor efficacy via hitchhiking of human serum albumin
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
679, С. 144 - 154
Опубликована: Окт. 16, 2024
Язык: Английский
Advancing Cancer Drug Delivery with Nanoparticles: Challenges and Prospects in Mathematical Modeling for In Vivo and In Vitro Systems
Cancers,
Год журнала:
2025,
Номер
17(2), С. 198 - 198
Опубликована: Янв. 9, 2025
Mathematical
models
are
crucial
for
predicting
the
behavior
of
drug
conjugate
nanoparticles
and
optimizing
delivery
systems
in
cancer
therapy.
These
simulate
interactions
among
nanoparticle
properties,
tumor
characteristics,
physiological
conditions,
including
resistance
targeting
specificity.
However,
they
often
rely
on
assumptions
that
may
not
accurately
reflect
vivo
conditions.
In
vitro
studies,
while
useful,
fully
capture
complexities
environment,
leading
to
an
overestimation
nanoparticle-based
therapy
effectiveness.
Advancements
mathematical
modeling,
supported
by
preclinical
data
artificial
intelligence,
vital
refining
therapies
improving
their
translation
into
effective
clinical
treatments.
Язык: Английский
Surface Functionalization of Nanocarriers with Anti-EGFR Ligands for Cancer Active Targeting
Nanomaterials,
Год журнала:
2025,
Номер
15(3), С. 158 - 158
Опубликована: Янв. 21, 2025
Active
cancer
targeting
consists
of
the
selective
recognition
overexpressed
biomarkers
on
cell
surfaces
or
within
tumor
microenvironment,
enabled
by
ligands
conjugated
to
drug
carriers.
Nanoparticle
(NP)-based
systems
are
highly
relevant
for
such
an
approach
due
their
large
surface
area
which
is
amenable
a
variety
chemical
modifications.
Over
past
decades,
several
studies
have
debated
efficiency
passive
targeting,
highlighting
active
as
more
specific
and
approach.
The
choice
conjugation
chemistry
attaching
nanocarriers
critical
ensure
stable
robust
system.
Among
panel
biomarkers,
epidermal
growth
factor
receptor
(EGFR)
stands
one
most
frequently
receptors
in
different
types.
design
development
with
surface-bound
anti-EGFR
vital
targeted
therapy,
relying
facilitated
capture
EGFR-overexpressing
cells
enabling
receptor-mediated
endocytosis
improve
accumulation
microenvironment.
In
this
review,
we
examine
examples
recent
significant
explore
various
strategies
NP
functionalization
biomolecules
small
molecular
ligands.
addition,
also
describe
some
common
characterization
techniques
confirm
analyze
patterns.
Язык: Английский
Nanostructured Formulations for a Local Treatment of Cancer: A Mini Review About Challenges and Possibilities
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 205 - 205
Опубликована: Фев. 6, 2025
Cancer
represents
a
significant
societal,
public
health,
and
economic
challenge.
Conventional
chemotherapy
is
based
on
systemic
administration;
however,
it
has
current
limitations,
including
poor
bioavailability,
high-dose
requirements,
adverse
side
effects,
low
therapeutic
indices,
the
development
of
multiple
drug
resistance.
These
factors
underscore
need
for
innovative
strategies
to
enhance
delivery
directly
tumours.
However,
local
treatment
also
presents
challenges,
penetration
through
endothelial
layers,
tissue
density
in
tumour
microenvironment,
interstitial
fluid
pressure,
physiological
conditions
within
tumour,
permanence
at
site
action.
Nanotechnology
promising
alternative
addressing
these
challenges.
This
narrative
review
elucidates
potential
nanostructured
formulations
cancer
treatment,
providing
illustrative
examples
an
analysis
advantages
challenges
associated
with
this
approach.
Among
nanoformulations
developed
breast,
bladder,
colorectal,
oral,
melanoma
cancer,
polymeric
nanoparticles,
liposomes,
lipid
nanohydrogels
have
demonstrated
particular
efficacy.
systems
permit
mucoadhesion
enhanced
penetration,
thereby
increasing
concentration
(bioavailability)
consequently
improving
anti-tumour
efficacy
potentially
reducing
effects.
In
addition
studies
indicating
chemotherapy,
nanocarriers
can
be
used
as
theranostic
approach
combination
irradiation
methods.
Язык: Английский
A computer-aided, carrier-free drug delivery system with enhanced cytotoxicity and biocompatibility: a universal model for multifunctional lung cancer therapy
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
250, С. 114557 - 114557
Опубликована: Фев. 9, 2025
Язык: Английский
From Bench to Bedside: Transforming Cancer Therapy with Protease Inhibitors
Targets,
Год журнала:
2025,
Номер
3(1), С. 8 - 8
Опубликована: Март 3, 2025
Proteases
play
a
pivotal
role
in
cancer
progression,
facilitating
processes
such
as
extracellular
matrix
degradation,
angiogenesis,
and
metastasis.
Consequently,
protease
inhibitors
have
emerged
promising
therapeutic
agents
oncology.
This
review
provides
comprehensive
overview
of
the
mechanisms
by
which
modulate
biology,
categorizing
their
target
classes,
including
metalloproteinases,
cysteine
proteases,
serine
proteases.
We
discuss
potential
both
synthetic
natural
inhibitors,
highlighting
applications
preclinical
clinical
settings.
Furthermore,
challenges
specificity,
toxicity,
resistance
are
addressed,
alongside
strategies
to
overcome
these
limitations
through
innovative
drug
designs
combination
therapies.
The
future
treatment
lies
precision
medicine,
leveraging
proteomic
profiling
tailor
therapies
individual
tumors.
underscores
importance
ongoing
research
development
novel
approaches
harness
effectively
for
management.
Язык: Английский