Nano TransMed,
Год журнала:
2024,
Номер
3, С. 100040 - 100040
Опубликована: Июнь 27, 2024
Currently,
cancer
is
the
leading
cause
of
death
globally.
In
absence
specific
treatment
and
early
diagnosis,
procedures
like
surgery,
chemotherapy,
radiation
therapy
are
often
used
to
manage
disease.
However,
these
approaches
fail
control
due
inefficacy,
nonspecific
distribution,
side
effects
drugs.
Anticancer
drugs
essential
in
reducing
cell
growth
helping
damage
those
cells.
severe
have
limited
bioavailability
their
distribution
throughout
body.
Therefore,
development
intelligent
drug
release
systems
essential.
Nanoparticle
delivery
promising
strategies
improve
therapeutic
efficacy
safety,
overcoming
challenges.
Among
systems,
a
natural
polysaccharide
called
chitosan,
derivative
chitin,
has
gained
considerable
attention
as
biocompatible,
biodegradable,
mucoadhesive
material
for
creating
nanoparticles.
Chitosan
nanoparticles
provide
several
advantages,
including
improved
stability,
cellular
uptake,
solubility
anticancer
drugs,
modulation
kinetics,
biodistribution.
Additionally,
chitosan
can
be
modified
on
surface
with
ligands
or
stimuli-responsive
moieties
achieve
targeted
cells
tissues.
This
review
explores
recent
advances
chitosan-based
nanoparticle
delivery,
efficacy,
applications
therapy.
Chitosan,
a
copolymer
of
glucosamine
and
N-acetyl
glucosamine,
is
derived
from
chitin.
Chitin
found
in
cell
walls
crustaceans,
fungi,
insects
some
algae,
microorganisms,
invertebrate
animals.
Chitosan
emerging
as
very
important
raw
material
for
the
synthesis
wide
range
products
used
food,
medical,
pharmaceutical,
health
care,
agriculture,
industry,
environmental
pollution
protection.
This
review,
line
with
focus
this
special
issue,
provides
reader
(1)
an
overview
on
different
sources
chitin,
(2)
advances
techniques
to
extract
chitin
converting
it
into
chitosan,
(3)
importance
inherent
characteristics
chitosan
that
makes
them
suitable
specific
applications
and,
finally,
(4)
briefly
summarizes
ways
tailoring
applications.
The
review
also
presents
influence
degree
acetylation
(DA)
deacetylation
(DDA),
molecular
weight
(Mw)
physicochemical
biological
properties
acid-base
behavior,
biodegradability,
solubility,
reactivity,
among
many
other
determine
processability
suitability
intended
help
guide
researchers
select
right
their
Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 355 - 376
Опубликована: Ноя. 26, 2023
Natural
polymers
are
complex
organic
molecules
that
occur
in
the
natural
environment
and
have
not
been
subjected
to
artificial
synthesis.
They
frequently
encountered
various
creatures,
including
mammals,
plants,
microbes.
The
aforementioned
commonly
derived
from
renewable
sources,
possess
a
notable
level
of
compatibility
with
living
organisms,
limited
adverse
effect
on
environment.
As
result,
they
hold
considerable
significance
development
sustainable
environmentally
friendly
goods.
In
recent
times,
there
has
advancement
investigation
potential
uses
field
biomedicine,
specifically
relation
biomaterials
exhibit
antibacterial
antioxidant
characteristics.
This
review
provides
comprehensive
overview
prevalent
utilized
biomedical
domain
throughout
preceding
two
decades.
this
paper,
we
present
examination
components
typical
methods
for
preparation
based
polymers.
Furthermore,
summarize
application
polymer
materials
each
stage
skin
wound
repair.
Finally,
key
findings
insights
into
limitations
current
elucidate
prospects
their
future
field.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(23), С. 15134 - 15134
Опубликована: Дек. 1, 2022
This
review
presents
data
from
the
past
five
years
on
use
of
polymeric
superabsorbent
hydrogels
in
agriculture
as
water
and
nutrient
storage
retention
materials,
well
additives
that
improve
soil
properties.
The
synthetic
natural
for
these
purposes
is
considered.
Although
polymers,
such
various
polysaccharides,
have
undoubted
advantages
related
to
their
biocompatibility,
biodegradability,
low
cost,
they
are
inferior
polymers
terms
absorption
In
this
regard,
most
promising
semi-synthetic
superabsorbents
based
modified
with
or
grafted
chains
which
can
combine
without
disadvantages.
Such
great
interest
agricultural
applications,
especially
dry
regions,
also
because
be
used
create
systems
slow
release
nutrients
into
soil,
necessary
increase
crop
yields
using
environmentally
friendly
technologies.
