Abstract
Due
to
the
lack
of
other
treatment
options,
a
rebirth
polymyxins
is
urgently
required.
Colistin
(also
called
polymyxin
E)
and
B
are
only
two
examples
this
antibiotic
class
that
were
effectively
employed
in
such
critical
situations.
In
present
work,
both
studied
medications
quantified
via
simple,
green,
non-extracting
spectrophotometric
approach
based
on
formation
ion-pair
complexes
with
Erythrosine
B.
Without
using
any
organic
solvents,
pink
color
created
was
detected
at
wavelength
=
558
nm.
To
achieve
highest
intensity
absorbance,
optimum
conditions
established
by
screening
many
experimental
factors
as
pH,
buffer
volume,
volume
B,
time
consumed
undergo
reaction.
For
Polymyxin
respectively,
Beer-Lambert’s
law
observed
concentration
ranges
1–6,
1–9
µg
mL
−
1
.
The
technique
approved
validated
following
ICH
recommendations.
Lastly,
suggested
has
been
successfully
implemented
quantify
cited
colorimetrically,
for
first
time,
their
parenteral
dosage
forms
excellent
recoveries.
Also,
Content
uniformity
testing
implemented.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 27, 2024
Abstract
Nowadays,
scientists
are
currently
attempting
to
lessen
the
harmful
effects
of
chemicals
on
environment.
Stability
testing
identifies
how
a
drug’s
quality
changes
over
time.
The
current
work
suggests
first
and
sustainable
differential
pulse
voltammetry
technique
for
quantifying
difluprednate
(DIF)
as
an
anti-inflammatory
agent
in
presence
its
alkaline
degradation
product
(DEG).
optimum
conditions
developed
method
were
investigated
with
glassy
carbon
electrode
scan
rate
100
mV
s
−1
.
linearity
range
was
2.0
×
10
−7
–1.0
−6
M
DIF.
DIF
found
undergo
degradation,
when
refluxed
8
h
using
NaOH,
DEG
successfully
characterized
utilizing
IR
MS/MS.
intended
approach
demonstrated
selectivity
identification
pure,
pharmaceutical,
forms.
student’s
t-test
F
value
used
compare
suggested
reported
approaches
statistically.
results
validated
according
ICH
requirements.
greenness
studied
evaluated
Green
Analytical
Procedure
Index
Greenness
metric.
Additionally,
whiteness
features
proposed
examined
recently
released
red,
green,
blue
12
model,
recommended
strategy
performed
better
than
whiteness.
Abstract
Aspartame
is
an
artificial
sweetener
used
in
drinks
and
many
foods.
International
Agency
for
Research
on
Cancer
classified
aspartame
as
possibly
carcinogenic
to
humans
(IARC
Group
2B).
In
this
study,
a
sensitive
selective
spectrofluorimetric
method
was
developed
detect
aspartame.
The
based
switching
the
fluorescence
activity
of
upon
its
condensation
with
O‐phthalaldehyde
(Roth's
reaction)
presence
2‐mercaptoethanol.
reaction
product
detected
fluorometrically
at
λ
em
438
nm
after
ex
340
nm.
All
conditions
required
yield
optimal
intensity
were
observed
investigated.
Furthermore,
approach
validated
according
ICH
guidelines.
Upon
plotting
concentrations
against
their
associated
values,
relationship
between
two
variables
linear
within
range
0.5–3.0
μg/mL.
employed
analyze
quantity
commercial
packages
soft
acceptable
level
recovery.
addition,
Green
Solvents
Selecting
Tool,
Complementary
Analytical
Procedure
Index,
Greenness
Metric
tool
evaluate
sustainability
greenness
methodology.
Journal of The Electrochemical Society,
Год журнала:
2024,
Номер
171(7), С. 077512 - 077512
Опубликована: Июль 1, 2024
This
study
presents
a
sustainable
electrochemical
investigation
of
pramipexole
(PRA)
in
pharmaceuticals
and
human
plasma,
using
cyclic
differential
pulse
voltammetry.
Key
parameters,
including
potential
range,
buffer
pH,
accumulation
period,
scan
rate
were
optimized,
establishing
efficient
voltammetric
methods
for
PRA
analysis.
The
analytical
range
was
0.60–12.00
μ
g
ml
−1
,
with
detection
limit
0.14
correlation
coefficient
0.9998.
Recovery
rates
ranged
from
98.60
±
0.26%
to
101.33
0.38%,
validating
the
methodology’s
applicability
plasma
an
average
recovery
99.25
0.45%.
highlights
environmental
sustainability
developed
electrode,
evaluated
through
SWOT
analysis,
assesses
greenness
impact
tools
like
Complementary
Green
Analytical
Procedure
Index
(ComplexGAPI),
(AGREE)
sample
preparation
(AGREEprep).
Significantly,
this
work
aligns
numerous
United
Nations
Sustainable
Development
Goals
(UN-SDGs),
specifically
goals
3,
4,
5,
7,
9,
11,
12,
13,
14,
15,
17,
illustrating
our
commitment
pharmaceutical
research.
method
further
quantified
newly
introduced
Need,
Quality,
Sustainability
(NQS)
index,
demonstrating
significant
alignment
practices.
Future Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
10(1)
Опубликована: Июнь 6, 2024
Abstract
Background
The
management
of
pain
presents
a
significant
challenge
in
healthcare,
particularly
cases
where
conventional
therapies
prove
inadequate.
In
response
to
this
need,
study
aims
devise
two
innovative
UV
spectrophotometric
techniques
rooted
the
principles
green
analytical
chemistry
for
analysis
Aceclofenac
(ACE),
Paracetamol
(PAR),
and
Tramadol
(TRM)
both
bulk
tablet
forms.
Results
Utilizing
advanced
mathematical
methodologies
such
as
double
divisor
ratio
spectra
method
area
under
curve,
concentrations
these
drugs
were
accurately
determined.
Validation
developed
methods
adhered
guidelines
outlined
by
International
Council
Harmonisation
Q2
(R1),
revealing
linear
calibration
curves
ACE
(8–12
µg/mL),
PAR
(22.75–35.75
TRM
(2.62–4.12
µg/mL).
Furthermore,
statistical
analyses
employing
Student’s
t
test
F
conducted
ensure
robustness
proposed
method.
evaluation
environmental
impact
through
metric
tools
confirmed
eco-friendliness
methodologies.
Conclusion
assessment
performed
utilizing
has
substantiated
sustainability
approach.
Thus,
methodology
offers
accurate
reliable
outcomes
determination
three
drugs,
indicated
complete
overlap
observed
zero-order
spectra.
Analytica—A Journal of Analytical Chemistry and Chemical Analysis,
Год журнала:
2025,
Номер
6(1), С. 10 - 10
Опубликована: Март 11, 2025
Green
analytical
chemistry
represents
a
transformative
approach
to
science,
emphasizing
sustainability
and
environmental
stewardship
while
maintaining
high
standards
of
accuracy
precision.
This
review
highlights
recent
innovations
in
green
chemistry,
including
the
use
solvents,
such
as
water,
supercritical
carbon
dioxide,
ionic
liquids,
bio-based
alternatives,
well
energy-efficient
techniques
like
microwave-assisted,
ultrasound-assisted,
photo-induced
processes.
Advances
instrumentation,
miniaturized
portable
devices,
integration
automation
chemometric
tools,
have
further
enhanced
efficiency
reduced
footprint
workflows.
Despite
these
advancements,
challenges
remain,
need
balance
performance
with
eco-friendliness
lack
global
measure
promote
sustainable
practices
consistently.
However,
future
looks
promising,
emerging
technologies
artificial
intelligence
digital
tools
offering
new
ways
optimize
workflows,
minimize
waste,
streamline
By
focusing
on
areas,
is
transforming
methodologies
into
that
not
only
achieve
but
also
align
goals.
underscores
how
more
than
just
scientific
discipline,
pathway
for
reducing
ecological
impact
processes
driving
innovation
science
industry.
With
continued
commitment
research,
collaboration,
adoption
cutting-edge
technologies,
has
potential
shape
greener
its
diverse
applications.
