Methods, Год журнала: 2021, Номер 199, С. 9 - 15
Опубликована: Май 14, 2021
Язык: Английский
Biomaterials Research, Год журнала: 2019, Номер 23(1)
Опубликована: Ноя. 21, 2019
In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring therapy. The term "nanomaterials" describes materials with nanoscale dimensions (< 100 nm) broadly classified into natural synthetic nanomaterials. However, "engineered" nanomaterials have received significant attention due to their versatility. Although enormous strides been made research development field nanotechnology, it is often confusing for beginners make an informed choice regarding nanocarrier system its potential applications. Hence, this review, we endeavored briefly explain most commonly used nanomaterials, core properties how surface functionalization would facilitate competent delivery drugs or therapeutic molecules. Similarly, suitability carbon-based like CNT QD has discussed targeted drug siRNA One biggest challenges formulation systems fulfilling targeted/specific delivery, controlling release preventing opsonization. Thus, a different mechanism targeting, role suitable drug-laden fabrication methods augment solubility bioavailability discussed. Additionally, routes administration provide greater understanding biological other barriers impact on transport. overall aim article straightforward perception design, various nanoparticle associated each method.
Язык: Английский
Процитировано
839
Biomedicine & Pharmacotherapy, Год журнала: 2018, Номер 103, С. 598 - 613
Опубликована: Апрель 24, 2018
Язык: Английский
Процитировано
490
Pharmaceutics, Год журнала: 2019, Номер 11(2), С. 55 - 55
Опубликована: Янв. 29, 2019
Non-Ionic surfactant based vesicles, also known as niosomes, have attracted much attention in pharmaceutical fields due to their excellent behavior encapsulating both hydrophilic and hydrophobic agents. In recent years, it has been discovered that these vesicles can improve the bioavailability of drugs, may function a new strategy for delivering several typical therapeutic agents, such chemical protein drugs gene materials with low toxicity desired targeting efficiency. Compared liposomes, niosomes are more stable during formulation process storage. The required pharmacokinetic properties be achieved by optimizing components or surface modification. This novel delivery system is easy prepare scale up production costs. this paper, we summarize structure, components, methods, quality control niosome its applications delivery.
Язык: Английский
Процитировано
445
Drug Delivery and Translational Research, Год журнала: 2021, Номер 12(4), С. 758 - 791
Опубликована: Янв. 20, 2021
Abstract Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed products global market. The use these can overcome associated drawbacks other routes, such as oral parenteral. authors will review current trends, future applications transdermal technologies, with specific focus on providing a comprehensive understanding enhancement strategies. This article initially discuss each method used development first-generation products. These methods include drug/vehicle interactions, vesicles particles, stratum corneum modification, energy-driven bypassing techniques. Through suitable design implementation active methods, notably microneedle technology, been shown to deliver both low high molecular weight drugs. Microneedle platforms proven themselves be more versatile than opportunities for intradermal drugs/biotherapeutics therapeutic monitoring. that microneedles prospective strategy improving systems. Graphical abstract
Язык: Английский
Процитировано
388
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2019, Номер 144, С. 18 - 39
Опубликована: Авг. 22, 2019
Язык: Английский
Процитировано
364
Journal of Nanomaterials, Год журнала: 2016, Номер 2016, С. 1 - 13
Опубликована: Янв. 1, 2016
Drug delivery systems are defined as formulations aiming for transportation of a drug to the desired area action within body. The basic component is an appropriate carrier that protects from rapid degradation or clearance and thereby enhances concentration in target tissues. Based on their biodegradable, biocompatible, nonimmunogenic structure, niosomes promising carriers formed by self-association nonionic surfactants cholesterol aqueous phase. In recent years, numerous research articles have been published scientific journals reporting potential serve different types drugs. present review describes preparation methods, characterization techniques, studies niosomal also gives up date information regarding applications delivery.
Язык: Английский
Процитировано
343
Journal of Drug Delivery Science and Technology, Год журнала: 2020, Номер 56, С. 101581 - 101581
Опубликована: Фев. 11, 2020
Язык: Английский
Процитировано
297
Chemical Society Reviews, Год журнала: 2016, Номер 45(23), С. 6520 - 6545
Опубликована: Янв. 1, 2016
Multifunctional
lipid-based
nanovesicles
(L-NVs)
prepared
by
molecular
self-assembly
of
membrane
components
together
with
(bio)-active
molecules,
means
compressed
CO2-media
or
other
non-conventional
methods
lead
to
highly
homogeneous,
tailor-made
that
are
used
for
advanced
nanomedicine.
Confocal
microscopy
image
siRNA
transfection
using
L-NVs,
reprinted
permission
from
de
Jonge,
Язык: Английский
Процитировано
259
Critical Reviews in Food Science and Nutrition, Год журнала: 2018, Номер 59(21), С. 3468 - 3497
Опубликована: Июль 13, 2018
Curcumin is the main polyphenol of curcuminoid class turmeric, a well-known spice belonging to ginger family. In addition its common applications like coloring and antioxidant agent as food additives, it has broad range favorable biological functions, such anti-inflammatory, anti-microbial, anti-diabetic activities, anti-cancer potentials against various cancers. However, curcumin suffers from some limitations including short shelf life due poor chemical stability, low bioavailability absorption, water solubility, rapid metabolism systemic elimination. Nanoencapsulaion been addressed an innovative emerging technology for resolving these shortcomings. this review, different delivery systems used loading have considered explained lipid-based, polymer biopolymer-based, nature-inspired, special equipment-based surfactant-based techniques. Also, implications nanoencapsulated in food, pharmaceutical cosmetic uses are discussed. sense, relevant recent studies past few years along with upcoming challenges covered. Although incorporation into nanocarriers can be possible solution overcome inherent constraints, there rational concerns about their toxicological safety once they enter paths. Therefore, future investigations could focus on assessment fate during digestion absorption within human body.
Язык: Английский
Процитировано
256
Journal of Controlled Release, Год журнала: 2019, Номер 298, С. 38 - 67
Опубликована: Фев. 10, 2019
Язык: Английский
Процитировано
248