ACS Sensors,
Год журнала:
2022,
Номер
7(8), С. 2387 - 2399
Опубликована: Июль 22, 2022
Analyzing
interstitial
fluid
(ISF)
via
microneedle
(MN)
devices
enables
patient
health
monitoring
in
a
minimally
invasive
manner
and
point-of-care
settings.
However,
most
MN-based
diagnostic
approaches
require
complicated
fabrication
processes
postprocessing
of
the
extracted
ISF
or
are
limited
to
detection
electrochemically
active
biomarkers.
Here,
we
show
on-needle
measurement
target
analytes
by
integrating
hydrogel
microneedles
with
aptamer
probes
as
recognition
elements.
Fluorescently
tagged
chemically
attached
matrix
using
simple
novel
approach,
while
cross-linked
patch
is
formed.
For
reagentless
detection,
employ
strand
displacement
strategy
where
fluorophore-conjugated
aptamers
hybridized
DNA
competitor
conjugated
quencher
molecule.
The
assay
utilized
for
rapid
(2
min)
glucose,
adenosine
triphosphate,
l-tyrosinamide,
thrombin
ex
vivo.
Furthermore,
system
specific
sensitive
quantification
rising
falling
concentrations
glucose
an
animal
model
diabetes
track
hypoglycemia,
euglycemia,
hyperglycemia
conditions.
Our
can
be
applied
diverse
range
biomarkers,
proteins,
small
molecules,
introducing
generalizable
platform
biomolecule
quantification,
has
potential
improve
quality
life
patients
who
need
close
biomarkers
disease.
Biomaterials Research,
Год журнала:
2021,
Номер
25(1)
Опубликована: Фев. 12, 2021
Various
non-invasive
administrations
have
recently
emerged
as
an
alternative
to
conventional
needle
injections.
A
transdermal
drug
delivery
system
(TDDS)
represents
the
most
attractive
method
among
these
because
of
its
low
rejection
rate,
excellent
ease
administration,
and
superb
convenience
persistence
patients.
TDDS
could
be
applicable
in
not
only
pharmaceuticals
but
also
skin
care
industry,
including
cosmetics.
Because
this
mainly
involves
local
it
can
prevent
buildup
concentration
nonspecific
tissues
targeted
by
drug.
However,
physicochemical
properties
translate
multiple
obstacles
restrictions
delivery,
with
numerous
investigations
conducted
overcome
bottlenecks.
In
review,
we
describe
different
types
available
methods,
along
a
critical
discussion
specific
advantages
disadvantages,
characterization
potential
each
method.
Progress
research
on
methods
has
established
high
efficiency
inherent
TDDS,
which
is
expected
find
applications
wide
range
fields.
Polymers,
Год журнала:
2021,
Номер
13(16), С. 2815 - 2815
Опубликована: Авг. 22, 2021
Drug
delivery
through
the
skin
offers
many
advantages
such
as
avoidance
of
hepatic
first-pass
metabolism,
maintenance
steady
plasma
concentration,
safety,
and
compliance
over
oral
or
parenteral
pathways.
However,
biggest
challenge
for
transdermal
is
that
only
a
limited
number
potent
drugs
with
ideal
physicochemical
properties
can
passively
diffuse
intercellularly
permeate
barriers
achieve
therapeutic
concentration
by
this
route.
Significant
efforts
have
been
made
toward
development
approaches
to
enhance
permeation
drugs.
Among
them,
microneedles
represent
one
microscale
physical
enhancement
methods
greatly
expand
spectrum
intradermal
delivery.
Microneedles
typically
measure
0.1–1
mm
in
length.
In
review,
microneedle
materials,
fabrication
routes,
characterization
techniques,
applications
are
discussed.
A
variety
materials
silicon,
stainless
steel,
polymers
used
fabricate
solid,
coated,
hollow,
dissolvable
microneedles.
Their
implications
drug
discussed
extensively.
there
remain
challenges
sustained
delivery,
efficacy,
cost-effective
fabrication,
large-scale
manufacturing.
This
review
discusses
different
modes
gaps
manufacturing
technologies
associated
also
their
potential
impact
on
vaccine
disease
diagnostic,
cosmetics
applications.
Pharmaceutics,
Год журнала:
2022,
Номер
14(6), С. 1152 - 1152
Опубликована: Май 28, 2022
The
ideal
drug
delivery
system
has
a
bioavailability
comparable
to
parenteral
dosage
forms
but
is
as
convenient
and
easy
use
for
the
patient
oral
solid
forms.
In
recent
years,
there
been
increased
interest
in
transdermal
(TDD)
non-invasive
approach
that
generally
regarded
being
administer
more
vulnerable
age
groups,
such
paediatric
geriatric
patients,
while
avoiding
certain
concerns
arise
from
due
poor
absorbability
metabolism
concerns.
However,
despite
its
many
merits,
TDD
remains
restricted
select
few
drugs.
physiology
of
skin
poses
barrier
against
feasible
drugs,
limiting
applicability
only
those
drugs
possess
physicochemical
properties
allowing
them
be
successfully
delivered
transdermally.
Several
techniques
have
developed
enhance
permeability
Both
chemical
(e.g.,
thermal
mechanical)
passive
(vesicle,
nanoparticle,
nanoemulsion,
dispersion,
nanocrystal)
investigated
substances
across
skin.
Furthermore,
hybrid
approaches
combining
penetration
enhancement
technologies
with
physical
are
intensively
researched
improve
permeation
substances.
This
review
aims
summarize
trends
discuss
merits
drawbacks
various
chemical,
physical,
currently
improving
Journal of Controlled Release,
Год журнала:
2023,
Номер
355, С. 624 - 654
Опубликована: Фев. 17, 2023
Lipid
vesicles
can
provide
a
cost-effective
enhancement
of
skin
drug
absorption
when
vesicle
production
process
is
optimised.
It
an
important
challenge
to
design
the
ideal
vesicle,
since
their
properties
and
features
are
related,
as
changes
in
one
affect
others.
Here,
we
review
main
components,
preparation
characterization
methods
commonly
used,
key
that
lead
highly
efficient
for
transdermal
delivery
purposes.
We
stand
by
size,
deformability
degree
loading,
most
determine
further
absorption.
The
interest
this
technology
increasing,
demonstrated
exponential
growth
publications
on
topic.
Although
long-term
preservation
scalability
issues
have
limited
commercialization
lipid
products,
freeze-drying
modern
escalation
overcome
these
difficulties,
thus
predicting
higher
use
technologies
market
clinical
practice.
Pharmaceutics,
Год журнала:
2023,
Номер
15(1), С. 277 - 277
Опубликована: Янв. 13, 2023
Transdermal
delivery
provides
numerous
benefits
over
conventional
routes
of
administration.
However,
this
strategy
is
generally
limited
to
a
few
molecules
with
specific
physicochemical
properties
(low
molecular
weight,
high
potency,
and
moderate
lipophilicity)
due
the
barrier
function
stratum
corneum
layer.
Researchers
have
developed
several
physical
enhancement
techniques
expand
applications
transdermal
field;
among
these,
microneedle
technology
has
recently
emerged
as
promising
platform
deliver
therapeutic
agents
any
size
into
across
skin.
Typically,
hydrophilic
biomolecules
cannot
penetrate
skin
by
passive
diffusion.
Microneedle
insertion
disrupts
integrity
compromises
its
protective
function,
thus
creating
pathways
(microchannels)
for
enhanced
permeation
macromolecules.
Microneedles
not
only
improve
stability
but
also
enhance
various
biomolecules.
Academic
institutions
industrial
companies
invested
substantial
resources
in
development
systems
biopharmaceutical
delivery.
This
review
article
summarizes
most
recent
research
provide
comprehensive
discussion
about
microneedle-mediated
macromolecules,
covering
topics
from
introduction
skin,
delivery,
microneedles,
biopharmaceuticals
(current
status,
administration,
issues),
different
types,
clinical
trials,
safety
acceptability
manufacturing
regulatory
issues,
future
technology.
Advanced Materials,
Год журнала:
2023,
Номер
35(28)
Опубликована: Апрель 24, 2023
Wound
dressing
patches
based
on
stem
cells
have
demonstrated
promising
potential
in
the
treatment
of
diabetic
wounds,
while
their
capabilities
maintenance
cell
stemness,
effective
exchange
cellular
substance,
and
precise
targeting
remain
to
be
promoted.
Here,
a
novel
spheroid
loaded
microneedle
(MN@SPs)
patch
is
presented
using
microfluidic
templating
technology.
By
leveraging
fluid
manipulation
template,
spheroids
(SPs)
with
uniform
size
can
generated
situ.
The
resulting
SPs
exhibit
advanced
viability
functions,
as
evidenced
by
overexpressed
genes
related
extracellular
matrix
organization
angiogenesis.
loading
these
into
microneedles
(MNs),
platform
enables
delivery
multiple
active
substances,
which
contribute
neovascularization,
collagen
deposition,
tissue
reconstruction
wounds.
Overall,
this
microfluidic-engineered
therapy
demonstrates
significant
promise
promoting
wound
healing.
Molecular Pharmaceutics,
Год журнала:
2023,
Номер
20(7), С. 3278 - 3297
Опубликована: Июнь 6, 2023
In
recent
years,
significant
progress
has
been
made
in
transdermal
drug
delivery
systems,
but
there
is
still
a
search
for
enhancers
that
can
improve
the
absorption
of
active
substances
through
stratum
corneum.
Although
permeation
have
described
scientific
literature,
use
naturally
occurring
this
role
particular
interest,
because
they
offer
high
level
safety
use,
with
low
risk
skin
irritation,
and
efficiency.
addition,
these
ingredients
are
biodegradable,
easily
available,
widely
accepted
by
consumers
due
to
growing
trust
natural
compounds.
This
article
provides
information
on
derived
compounds
systems
help
them
penetrate
skin.
The
work
focuses
components
found
corneum
such
as
sterols,
ceramides,
oleic
acid,
urea.
Penetration
nature,
mainly
plants,
terpenes,
polysaccharides,
fatty
acids
also
described.
mechanism
action
discussed,
methods
assessing
their
penetration
efficiency
provided.
Our
review
covers
original
papers
from
2017
2022,
supplemented
papers,
then
older
publications
used
supplement
or
verify
data.
shown
increase
transport
compete
synthetic
counterparts.
Acta Pharmaceutica Sinica B,
Год журнала:
2023,
Номер
13(11), С. 4417 - 4441
Опубликована: Май 26, 2023
Rheumatoid
arthritis
is
a
chronic,
systemic
autoimmune
disease
predominantly
based
on
joint
lesions
with
an
extremely
high
disability
and
deformity
rate.
Several
drugs
have
been
used
for
the
treatment
of
rheumatoid
arthritis,
but
their
use
limited
by
suboptimal
bioavailability,
serious
adverse
effects,
nonnegligible
first-pass
effects.
In
contrast,
transdermal
drug
delivery
systems
(TDDSs)
can
avoid
these
drawbacks
improve
patient
compliance,
making
them
promising
option
(RA).
Of
course,
TDDSs
also
face
unique
challenges,
as
physiological
barrier
skin
makes
somewhat
limited.
To
overcome
this
maximize
efficiency,
evolved
in
terms
principle
facilitation
technology,
different
generations
derived,
which
significantly
improved
efficiency
even
achieved
individualized
controlled
delivery.
review,
we
summarize
systems,
corresponding
strategies,
applications
RA.
