International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(8), С. 4249 - 4249
Опубликована: Апрель 12, 2022
The
drugs
used
for
cancer
treatment
have
many
drawbacks,
as
they
damage
both
tumor
and
healthy
cells
and,
in
addition,
tend
to
be
poorly
soluble
drugs.
Their
transport
nanoparticles
can
solve
these
problems
release
the
drug
into
tissues,
well
improve
their
solubility,
bioavailability,
efficacy,
reducing
adverse
effects.
This
article
focuses
on
advantages
that
nanotechnology
bring
medicine,
with
special
emphasis
nanoliposomes.
For
this,
a
review
has
been
made
of
nanoliposomal
systems
marketed
cancer,
those
are
research
phase,
highlighting
clinical
trials
being
carried
out.
All
liposomes
studied
intravenously
administered,
showing
reduced
intensity
side-effects
compared
nonliposomal
form.
Doxorubicin
is
active
ingredient
most
frequently
employed.
Ongoing
expand
availability
liposomal
medicines
new
indications.
In
conclusion,
introduction
nanoliposomes
means
an
improvement
efficacy
quality
life
patients.
future
focus
could
directed
develop
multifunctional
targeted
using
anticancer
drugs,
different
types
existing
or
standardized
methodologies
easily
translated
industrial
scale.
Pharmaceuticals,
Год журнала:
2016,
Номер
9(4), С. 75 - 75
Опубликована: Ноя. 30, 2016
This
study
aims
to
provide
an
updated
survey
of
the
main
synthesis
methods
copper
oxide
(CuO)
nanoparticles
in
order
obtain
tailored
nanosystems
for
various
biomedical
applications.
The
approach
significantly
impacts
properties
such
and
these
turn
have
a
significant
impact
on
their
Although
not
widely
investigated
as
efficient
drug
delivery
system,
CuO
great
biological
including
effective
antimicrobial
action
against
wide
range
pathogens
also
resistant
bacteria.
These
led
development
approaches
with
direct
applications
field,
surfaces
effect,
wound
dressings
modified
textiles.
It
is
believed
that
could
represent
alternatives
smart
systems
utilized
both
detection
treatment
infections.
Advanced Functional Materials,
Год журнала:
2018,
Номер
29(2)
Опубликована: Ноя. 26, 2018
Abstract
The
versatile
electrospinning
technique
is
recognized
as
an
efficient
strategy
to
deliver
active
pharmaceutical
ingredients
and
has
gained
tremendous
progress
in
drug
delivery,
tissue
engineering,
cancer
therapy,
disease
diagnosis.
Numerous
delivery
systems
fabricated
through
regarding
the
carrier
compositions,
incorporation
techniques,
release
kinetics,
subsequent
therapeutic
efficacy
are
presented
herein.
Targeting
for
distinct
applications,
composition
of
carriers
vary
from
natural/synthetic
polymers/blends,
inorganic
materials,
even
hybrids.
Various
approaches
thoroughly
discussed
with
respect
principles,
benefits,
limitations.
To
meet
various
requirements
actual
sophisticated
vivo
environments
overcome
limitations
a
single
system,
feasible
combinations
multiple
drug‐inclusion
processes
via
could
be
employed
achieve
programmed,
multi‐staged,
or
stimuli‐triggered
drugs.
designed
electrospun
drug‐eluting
further
verified
biomedical
applications
comprehensively
overviewed,
demonstrating
promising
potential
address
variety
clinical
challenges.
ACS Nano,
Год журнала:
2018,
Номер
12(10), С. 9693 - 9701
Опубликована: Сен. 5, 2018
Topical
administration
of
anticancer
drugs
provides
a
potential
chemotherapeutic
modality
with
high
patient
compliance
for
cutaneous
melanoma.
However,
the
drug
delivery
efficiency
is
highly
limited
by
physiological
barriers
from
skin
to
tumor,
which
cannot
acquire
desired
therapeutic
efficacy.
Herein,
we
propose
paintable
oligopeptide
hydrogel
containing
paclitaxel
(PTX)-encapsulated
cell-penetrating-peptide
(CPP)-modified
transfersomes
(PTX-CTs)
enhance
transdermal
PTX
topical
melanoma
treatment.
After
being
plastered
on
above
PTX-CTs-embedded
(PTX-CTs/Gel)
as
patch
provided
prolonged
retention
capacity
PTX-CTs
skin.
The
superior
deformability
could
efficiently
squeeze
through
channels
in
stratum
coreum,
and
surfactant
components
improved
fluidity
lipid
molecules
corneum
further
permeation.
Moreover,
CPP
modification
rendered
PTX-CT-enhanced
penetration
tumor
stroma
well
efficient
transportation
cells.
were
shown
effectively
slow
growth
combination
systemic
chemotherapy
using
Taxol,
commercial
formulation
xenograft
B10F16
mouse
model.
RSC Advances,
Год журнала:
2020,
Номер
10(8), С. 4218 - 4231
Опубликована: Янв. 1, 2020
This
study
presents
the
influence
of
primary
formulation
parameters
on
formation
poly-dl-lactic-co-glycolic
nanoparticles
by
emulsification-solvent
evaporation,
and
nanoprecipitation
techniques.
In
evaporation
technique,
polymer
tensoactive
concentrations,
organic
solvent
fraction,
sonication
amplitude
effects
were
analyzed.
Similarly,
in
technique
fraction
injection
speed
varied.
Additionally,
agitation
during
centrifugation
speeds
use
cryoprotectants
freeze-drying
process
Nanoparticles
characterized
dynamic
light
scattering,
laser
Doppler
electrophoresis,
scanning
electron
microscopy,
results
evaluated
statistical
analysis.
Nanoparticle
physicochemical
characteristics
can
be
adjusted
varying
to
obtain
specific
sizes
stable
nanoparticles.
Also,
adjusting
these
parameters,
nanoparticle
preparation
processes
have
potential
tuned
yield
with
while
maintaining
reproducible
results.
Pharmaceutics,
Год журнала:
2022,
Номер
14(1), С. 106 - 106
Опубликована: Янв. 3, 2022
Nanotechnology
plays
a
significant
role
in
the
field
of
medicine
and
drug
delivery,
mainly
due
to
major
limitations
affecting
conventional
pharmaceutical
agents,
older
formulations
delivery
systems.
The
effect
nanotechnology
on
healthcare
is
already
being
felt,
as
various
applications
have
been
developed,
several
nanotechnology-based
medicines
are
now
market.
Across
many
parts
world,
draws
increasing
investment
from
public
authorities
private
sector.
Most
drug-delivery
systems
(CDDSs)
an
immediate,
high
release
after
administration,
leading
increased
administration
frequency.
Thus,
studies
carried
out
worldwide
focusing
development
nanomedicines
for
translation
into
products
manufactured
by
local
companies.
Pharmaceutical
nanomedicine
projected
play
global
market
system.
Our
objectives
were
examine
approved
Food
Drug
Administration
(FDA)
European
Medicines
Agency
(EMA)
market,
briefly
cover
challenges
faced
during
their
development,
look
at
future
perspectives.
Additionally,
importance
developing
products,
ideal
properties
nanocarriers,
reasons
behind
failure
some
nanomedicines,
important
considerations
will
be
discussed
brief.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2018,
Номер
14(2), С. 130 - 143
Опубликована: Май 10, 2018
Diabetes
is
one
of
the
most
prevalent
diseases
in
world
with
high-mortality
and
complex
complications
including
diabetic
foot
ulcer
(DFU).
It
has
been
reported
that
difficulties
repairing
wound
related
to
DFU
much
relationship
infection,
change
inflammatory
responses,
lack
extracellular
matrix
(ECM),
failure
angiogenesis.
Following
development
medical
materials
pharmaceutical
technology,
nanofibers
developed
by
electrospinning
huge
porosity,
excellent
humidity
absorption,
a
better
oxygen
exchange
rate,
some
antibacterial
activities.
That
say,
as
potential
material,
must
be
wonderful
candidate
for
treatment
so
many
benefits.
Careful
selection
polymers
from
natural
resource
synthetic
can
widen
nanofibrous
application.
Popular
methods
applied
fabrication
consist
uniaxial
coaxial
electrospinning.
Furthermore,
loading
chemical,
biochemical
active
ingredient
(API)
or
even
stem
cells
dosage
forms
DFU.
This
review
summarizes
present
techniques
dressing
(ND)
utilizes
variety
agents
offer
health
care
patients
suffering
Bioactive Materials,
Год журнала:
2017,
Номер
3(2), С. 201 - 211
Опубликована: Окт. 2, 2017
Skin
wound
healing
involves
a
coordinated
cellular
response
to
achieve
complete
reepithelialisation.
Elevated
levels
of
reactive
oxygen
species
(ROS)
in
the
environment
often
pose
hindrance
resulting
impaired
process.
Cerium
oxide
nanoparticles
(CeNPs)
have
ability
protect
cells
from
oxidative
damage
by
actively
scavenging
ROS.
Furthermore,
matrices
like
nanofibers
also
been
explored
for
enhancing
healing.
In
current
study
CeNP
functionalised
polycaprolactone
(PCL)-gelatin
nanofiber
(PGNPNF)
mesh
was
fabricated
electrospinning
and
evaluated
its
antioxidative
potential.
Wide
angle
XRD
analysis
randomly
oriented
revealed
∼2.6
times
reduced
crystallinity
than
pristine
PCL
which
aided
rapid
degradation
release
CeNP.
However,
bioactive
composite
made
between
PCL-gelatin
maintained
fibrous
morphology
PGNPNF
upto
14
days.
The
exhibited
superoxide
dismutase
(SOD)
mimetic
activity
due
incorporated
CeNPs.
enhanced
proliferation
3T3-L1
∼48%
as
confirmed
alamar
blue
assay
SEM
micrographs
grown
on
nanofibrous
mesh.
scavenged
ROS,
measured
relative
DCF
intensity
fluorescence
microscopy;
subsequently
increased
viability
three
folds
it
alleviated
stress.
Overall,
results
this
suggest
potential
applications.
