The
advent
of
immunotherapy
has
marked
a
new
era
in
cancer
treatment,
offering
significant
clinical
benefits.
Cell
membrane
as
drug
delivery
materials
played
crucial
role
enhancing
therapy
because
their
inherent
biocompatibility
and
negligible
immunogenicity.
Different
cell
membranes
are
prepared
into
nanovesicles
(CMNs),
but
CMNs
have
limitations
such
inefficient
targeting
ability,
low
efficacy,
unpredictable
side
effects.
Genetic
engineering
deepened
the
critical
immunotherapy,
enabling
genetically
engineered-CMN
(GCMN)-based
therapeutics.
To
date,
that
surface
modified
by
various
functional
proteins
been
developed
through
genetic
engineering.
Herein,
brief
overview
strategies
for
features
sources
is
discussed,
followed
description
GCMN
preparation
methods.
application
GCMNs
directed
at
different
immune
targets
addressed
challenges
prospects
translation.
Pharmaceutics,
Год журнала:
2023,
Номер
15(4), С. 1313 - 1313
Опубликована: Апрель 21, 2023
Chitosan,
a
biocompatible
and
biodegradable
polysaccharide
derived
from
chitin,
has
surfaced
as
material
of
promise
for
drug
delivery
biomedical
applications.
Different
chitin
chitosan
extraction
techniques
can
produce
materials
with
unique
properties,
which
be
further
modified
to
enhance
their
bioactivities.
Chitosan-based
systems
have
been
developed
various
routes
administration,
including
oral,
ophthalmic,
transdermal,
nasal,
vaginal,
allowing
targeted
sustained
release
drugs.
Additionally,
used
in
numerous
applications,
such
bone
regeneration,
cartilage
tissue
cardiac
corneal
periodontal
wound
healing.
Moreover,
also
utilized
gene
delivery,
bioimaging,
vaccination,
cosmeceutical
Modified
derivatives
improve
biocompatibility
resulting
innovative
promising
potentials
This
article
summarizes
the
recent
findings
on
its
application
science.
Abstract
The
oral
cavity
and
oropharynx
are
complex
environments
that
susceptible
to
physical,
chemical,
microbiological
insults.
They
also
common
sites
for
pathological
cancerous
changes.
effectiveness
of
conventional
locally‐administered
medications
against
diseases
affecting
these
milieus
may
be
compromised
by
constant
salivary
flow.
For
systemically‐administered
medications,
drug
resistance
adverse
side‐effects
issues
need
resolved.
New
strategies
delivery
have
been
investigated
over
the
last
decade
overcome
obstacles.
Synthesis
nanoparticle‐containing
agents
promote
healing
represents
a
quantum
leap
in
ensuring
safe,
efficient
affected
tissues.
Micro/nanoencapsulants
with
unique
structures
properties
function
as
more
favorable
drug‐release
platforms
than
treatment
approaches.
present
review
provides
an
overview
newly‐developed
nanocarriers
discusses
their
potential
applications
limitations
various
fields
dentistry
medicine.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Авг. 17, 2023
Abstract
Gene
therapy
holds
great
promise
for
treating
a
multitude
of
inherited
and
acquired
diseases
by
delivering
functional
genes,
comprising
DNA
or
RNA,
into
targeted
cells
tissues
to
elicit
manipulation
gene
expression.
However,
the
clinical
implementation
remains
substantially
impeded
lack
safe
efficient
delivery
vehicles.
This
review
comprehensively
outlines
novel
fastest-growing
non-viral
vectors,
which
include
liposomes
lipid
nanoparticles
(LNPs),
highly
branched
poly(β-amino
ester)
(HPAE),
single-chain
cyclic
polymer
(SCKP),
poly(amidoamine)
(PAMAM)
dendrimers,
polyethyleneimine
(PEI).
Particularly,
we
discuss
research
progress,
potential
development
directions,
remaining
challenges.
Additionally,
provide
comprehensive
overview
currently
approved
therapeutics,
as
well
ongoing
trials.
With
advances
in
biomedicine,
molecular
biology,
materials
science,
vectors
play
an
ever-expanding
noteworthy
role
therapy.
Cancer
is
one
of
the
top
life-threatening
dangers
to
human
survival,
accounting
for
over
10
million
deaths
per
year.
Bioactive
glasses
have
developed
dramatically
since
their
discovery
50
years
ago,
with
applications
that
include
therapeutics
as
well
diagnostics.
A
new
system
within
bioactive
glass
family,
mesoporous
(MBGs),
has
evolved
into
a
multifunctional
platform,
thanks
MBGs
easy-to-functionalize
nature
and
tailorable
textural
properties-surface
area,
pore
size,
volume.
Although
yet
meet
potential
in
tumor
treatment
imaging
practice,
recently
research
shed
light
on
distinguished
capabilities
promising
theranostic
systems
cancer
therapy.
This
review
presents
progress
field
MBG
diagnosis
therapy,
including
synthesis
MBGs,
mechanistic
overview
application
drug
monitoring,
therapy
(
particularly,
targeted
delivery
stimuli-responsive
nanoplatforms),
immunological
profile
MBG-based
nanodevices
reference
development
novel
therapeutics.
Nano-Micro Letters,
Год журнала:
2023,
Номер
15(1)
Опубликована: Фев. 8, 2023
Gene
therapy
provides
a
promising
approach
in
treating
cancers
with
high
efficacy
and
selectivity
few
adverse
effects.
Currently,
the
development
of
functional
vectors
safety
effectiveness
is
intense
focus
for
improving
delivery
nucleic
acid
drugs
gene
therapy.
For
this
purpose,
stimuli-responsive
nanocarriers
displayed
strong
potential
overall
efficiencies
reducing
effects
via
effective
protection,
prolonged
blood
circulation,
specific
tumor
accumulation,
controlled
release
profile
drugs.
Besides,
synergistic
could
be
achieved
when
combined
other
therapeutic
regimens.
This
review
summarizes
recent
advances
various
delivery.
Particularly,
responding
to
endogenous
stimuli
including
pH,
reactive
oxygen
species,
glutathione,
enzyme,
etc.,
exogenous
light,
thermo,
ultrasound,
magnetic
field,
are
introduced.
Finally,
future
challenges
prospects
toward
clinical
translation
well
discussed.
The
major
objective
present
biomedical
cancer
provide
guidance
developing
novel
nanoplatforms
that
clinically
applicable.
Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(7), С. 937 - 954
Опубликована: Июнь 9, 2023
During
the
last
decades,
ever-increasing
proportion
of
patients
with
cancer
has
been
led
to
serious
concerns
worldwide.
Therefore,
development
and
use
novel
pharmaceuticals,
like
nanoparticles
(NPs)-based
drug
delivery
systems
(DDSs),
can
be
potentially
effective
in
therapy.Poly
lactic-co-glycolic
acid
(PLGA)
NPs,
as
a
kind
bioavailable,
biocompatible,
biodegradable
polymers,
have
approved
by
Food
Drug
Administration
(FDA)
for
some
biomedical
pharmaceutical
applications.
PLGA
is
comprised
lactic
(LA)
glycolic
(GA)
their
ratio
could
controlled
during
various
syntheses
preparation
approaches.
LA/GA
determines
stability
degradation
time
PLGA;
lower
content
GA
results
fast
degradation.
There
are
several
approaches
preparing
NPs
that
affect
aspects,
such
size,
solubility,
stability,
loading,
pharmacokinetics,
pharmacodynamics,
so
on.These
indicated
sustained
release
site
passive
active
(via
surface
modification)
DDSs.
This
review
aims
provide
an
overview
approach
physicochemical
mechanism
cellular
fate,
DDSs
efficient
therapy,
status
industry
nanomedicine.
Frontiers in Oncology,
Год журнала:
2020,
Номер
10
Опубликована: Дек. 14, 2020
Cancer
is
the
second
cause
of
death
worldwide,
surpassed
only
by
cardiovascular
diseases,
due
to
lack
early
diagnosis,
and
high
relapse
rate
after
conventional
therapies.
Chemotherapy
inhibits
rapid
growth
cancer
cells,
but
it
also
affects
normal
cells
with
fast
proliferation
rate.
Therefore,
imperative
develop
other
safe
more
effective
treatment
strategies,
such
as
gene
therapy,
in
order
significantly
improve
survival
life
expectancy
patients
cancer.
The
aim
therapy
transfect
a
therapeutic
into
host
express
itself
beneficial
biological
effect.
However,
efficacy
proposed
strategies
has
been
insufficient
for
delivering
full
potential
clinic.
type
delivery
vehicle
(viral
or
non
viral)
chosen
depends
on
desired
specificity
therapy.
first
trials
were
performed
genes
driven
viral
promoters
CMV
promoter,
which
induces
non-specific
toxicity
tissues,
addition
cells.
use
tumor-specific
over-expressed
tumor,
specific
expression
given
increasing
their
localized
activity.
Several
cancer-
and/or
systems
have
developed
target
This
review
aims
provide
up-to-date
information
concerning
targeting
including
suppressor
genes,
suicide
anti-tumor
angiogenesis,
silencing,
gene-editing
technology,
well
employed.
Gene
can
be
used
complement
traditional
therapies
treatments.
