Journal of Biomedical Materials Research Part B Applied Biomaterials,
Год журнала:
2024,
Номер
112(2)
Опубликована: Янв. 22, 2024
Abstract
Millions
of
people
have
been
reported
with
tendon
injuries
each
year.
Unfortunately,
Tendon
are
increasing
rapidly
due
to
heavy
exercise
and
a
highly
aging
population.
In
addition,
the
introduction
3D‐printing
technology
in
area
repair
replacement
has
resolved
numerous
issues
significantly
improved
quality
artificial
tendons.
This
advancement
also
enabled
us
explore
identify
most
effective
combinations
biomaterials
that
can
be
utilized
this
field.
review
discusses
recent
development
3D‐printed
tendon;
where
recently,
some
research
investigated
suitable
pore
sizes,
diameter,
strength
for
scaffolds
high
cells
ingrowth
proliferation,
giving
better
understanding
effects
densities
structure
patterns
on
tendon's
mechanical
properties.
it
presents
divergence
between
tendons
other
tissue
how
different
techniques
models
participated
development.
Bioactive Materials,
Год журнала:
2024,
Номер
40, С. 597 - 623
Опубликована: Авг. 15, 2024
Tissue
engineering
technology
has
advanced
rapidly
in
recent
years,
offering
opportunities
to
construct
biologically
active
tissues
or
organ
substitutes
repair
even
enhance
the
functions
of
diseased
and
organs.
Tissue-engineered
scaffolds
rebuild
extracellular
microenvironment
by
mimicking
matrix.
Fibrin-based
possess
numerous
advantages,
including
hemostasis,
high
biocompatibility,
good
degradability.
Fibrin
provide
an
initial
matrix
that
facilitates
cell
migration,
differentiation,
proliferation,
adhesion,
also
play
a
critical
role
cell-matrix
interactions.
are
now
widely
recognized
as
key
component
tissue
engineering,
where
they
can
facilitate
defect
repair.
This
review
introduces
properties
fibrin,
its
composition,
structure,
biology.
In
addition,
modification
cross-linking
modes
fibrin
discussed,
along
with
various
forms
commonly
used
engineering.
We
describe
biofunctionalization
fibrin.
provides
detailed
overview
use
applications
skin,
bone,
nervous
tissues,
novel
insights
into
future
research
directions
for
clinical
treatment.
Advanced Functional Materials,
Год журнала:
2021,
Номер
32(15)
Опубликована: Дек. 22, 2021
Abstract
Anisotropic
microarchitectures
arising
from
an
aligned
organization
of
threadlike
extracellular
matrix
(ECM)
components
or
cells
are
ubiquitous
in
the
human
body,
such
as
skeletal
muscle,
corneal
stroma,
and
meniscus,
for
executing
tissue‐specific
physiological
functions.
It
is
widely
recognized
that
tissue
engineering,
whereby
growing
implanted
endogenous
anisotropic
scaffolds
with
geometrical
resemblance
to
ECM
targeted
tissues,
represents
a
promising
solution
structural
functional
restoration
these
tissues.
However,
remarkable
challenges
remain
recapitulating
complexities
native
tissues
beyond
simply
uniaxial
alignment.
Through
unremitting
endeavors
over
past
decade,
some
innovative
bioengineering
approaches
developed
tackle
challenges.
This
review
focuses
on
recent
progress
modular
assembly
3D
printing
techniques
exploited
construct
complex
key
highlight
their
accessibility
features
different
types
anisotropies,
based
understanding
whole
picture
anisotropies
alignment
which
geometrically
divided
into
three
categories.
Finally,
applications
either
vitro
modeling
vivo
regeneration,
explored.
Bioactive Materials,
Год журнала:
2022,
Номер
19, С. 179 - 197
Опубликована: Апрель 13, 2022
Tendon
and
ligament
(TL)
injuries
affect
millions
of
people
annually.
Biopolymers
play
a
significant
role
in
TL
tissue
repair,
whether
the
treatment
relies
on
engineering
strategies
or
using
artificial
tendon
grafts.
The
biopolymer
governs
mechanical
properties,
biocompatibility,
degradation,
fabrication
method
scaffold.
Many
natural,
synthetic
hybrid
biopolymers
have
been
studied
regeneration,
often
combined
with
therapeutic
agents
minerals
to
engineer
novel
scaffold
systems.
However,
most
advanced
not
clinical
use
yet.
Here,
we
aim
review
recent
discuss
their
features
for
engineering.
After
introducing
properties
native
tissue,
different
types
used
Then,
commercial
absorbable
non-absorbable
Finally,
explain
challenges
future
directions
development
regenerative
treatment.
Regenerative Biomaterials,
Год журнала:
2022,
Номер
9
Опубликована: Янв. 1, 2022
Abstract
With
an
increase
in
life
expectancy
and
the
popularity
of
high-intensity
exercise,
frequency
tendon
ligament
injuries
has
also
increased.
Owing
to
specificity
its
tissue,
rapid
restoration
injured
tendons
ligaments
is
challenging
for
treatment.
This
review
summarizes
latest
progress
cells,
biomaterials,
active
molecules
construction
technology
treating
tendon/ligament
injuries.
The
characteristics
supports
made
different
materials
development
application
manufacturing
methods
are
discussed.
natural
polymers,
synthetic
polymers
composite
boosted
use
scaffolds.
In
addition,
electrospinning
hydrogel
diversified
production
treatment
materials.
First,
this
article
briefly
introduces
structure,
function
biological
tendons/ligaments.
Then,
it
advantages
disadvantages
materials,
such
as
polymer
scaffolds,
scaffolds
extracellular
matrix
(ECM)-derived
regeneration.
We
then
discuss
applications
electrospun
fiber
hydrogels
regeneration
engineering.
Finally,
we
current
problems
future
directions
biomaterials
restoring
damaged
ligaments.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(1)
Опубликована: Сен. 15, 2023
Abstract
Physical
cues
like
morphology,
light,
electric
signal,
mechanic
magnetic
and
heat
can
be
used
as
alternative
regulators
for
expensive
but
short‐acting
growth
factors
in
bone
tissue
engineering
to
promote
osteogenic
differentiation
regeneration.
As
physical
stimulation
applied
directly
the
cannot
focused
on
defect
area
regulate
cell
behaviors
fate
situ,
this
limits
efficiency
of
precise
Biomaterials‐mediated
situ
cues,
an
effective
strategy
combining
synergistic
effect
materials
themselves,
are
put
forward
studied
widely
repair
efficiently
precisely.
Different
types
provide
different
choices
better
satisfy
requirements
targeted
repair.
In
review,
recent
research
about
biomaterials‐mediated
accelerating
osteogenesis
vitro
promoting
formation
vivo
is
introduced.
Meanwhile,
corresponding
possible
mechanisms
various
regulating
responses
also
discussed.
This
review
provides
useful
enlightening
guidance
utilization
intrinsically
properties
functional
achieve
efficient
regeneration,
leading
design
construction
smart
biomaterials
practical
applications,
eventually
clinical
translation.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 20, 2023
Tendon
injuries
often
result
in
significant
pain
and
disability
impose
severe
clinical
financial
burdens
on
our
society.
Despite
considerable
achievements
the
field
of
regenerative
medicine
past
several
decades,
effective
treatments
remain
a
challenge
due
to
limited
natural
healing
capacity
tendons
caused
by
poor
cell
density
vascularization.
The
development
tissue
engineering
has
provided
more
promising
results
regenerating
tendon-like
tissues
with
compositional,
structural
functional
characteristics
comparable
those
native
tendon
tissues.
Tissue
is
discipline
that
aims
restore
physiological
functions
using
combination
cells
materials,
as
well
suitable
biochemical
physicochemical
factors.
In
this
review,
following
discussion
structure,
injury
healing,
we
aim
elucidate
current
strategies
(biomaterials,
scaffold
fabrication
techniques,
cells,
biological
adjuncts,
mechanical
loading
bioreactors,
role
macrophage
polarization
regeneration),
challenges
future
directions
engineering.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15183 - 15183
Опубликована: Окт. 14, 2023
Tendon
aging
is
associated
with
an
increasing
prevalence
of
tendon
injuries
and/or
chronic
diseases,
such
as
tendinopathy,
which
affects
approximately
25%
the
adult
population.
Aged
tendons
are
often
characterized
by
a
reduction
in
number
and
functionality
stem/progenitor
cells
(TSPCs),
fragmented
or
disorganized
collagen
bundles,
increased
deposition
glycosaminoglycans
(GAGs),
leading
to
pain,
inflammation,
impaired
mobility.
Although
exact
pathology
unknown,
overuse
microtrauma
from
thought
be
major
causative
factors.
Due
hypovascular
hypocellular
nature
microenvironment,
healing
aged
related
difficult
using
current
pain/inflammation
surgical
management
techniques.
Therefore,
there
need
for
novel
therapies,
specifically
cellular
therapy
cell
rejuvenation,
due
decreased
regenerative
capacity
during
aging.
To
augment
therapeutic
strategies
treating
tendon-aging-associated
diseases
injuries,
comprehensive
understanding
needed.
This
review
summarizes
age-related
changes,
including
behaviors,
extracellular
matrix
(ECM)
composition,
biomechanical
properties
capacity.
Additionally,
impact
conventional
treatments
(diet,
exercise,
surgery)
discussed,
recent
advanced
(cell
rejuvenation)
highlighted
address
healing.
underscores
molecular
linkages
between
response,
provides
overview
tendons.
Understanding
underlying
rationale
future
basic
translational
studies
crucial
development
therapeutics
regeneration.
