Applied Sciences,
Год журнала:
2025,
Номер
15(5), С. 2301 - 2301
Опубликована: Фев. 21, 2025
Anterior
cruciate
ligament
(ACL)
injuries
pose
significant
challenges,
driving
the
need
for
innovative
repair
strategies.
Tissue
engineering
(TE)
has
emerged
as
a
promising
field
ACL
injuries.
Wet
spinning
is
filament
production
technique
that
enables
precise
control
over
alignment,
diameter,
and
porosity,
making
it
suitable
developing
new
scaffolds
This
study
develops
fibrous
using
wet
of
polycaprolactone
(PCL)
reinforced
with
cellulose
nanocrystals
(CNC)
to
enhance
mechanical
properties.
was
employed
fabricate
scaffolds,
utilizing
PCL
primary
polymer
due
its
favorable
biocompatibility
degradability.
An
automated
collector
developed
optimized,
which
allowed
stretching
filaments
diameters
low
30
µm.
Several
were
explored
characterized
SEM,
TGA,
tests.
The
optimized
PCL/CNC
used
develop
3D
braided
structures
mimic
structure.
combination
wet-spun
(with
an
stirring
method)
braiding
procedure
fully
biocompatible
both
structure
properties
native
ACL.
Cytotoxicity
tests
showed
cell
viability
proliferation
values
above
99%
81%,
respectively.
These
findings
underscore
potential
CNC-reinforced
candidates
repair,
laying
groundwork
future
biomedical
applications.
Journal of Biomedical Materials Research Part B Applied Biomaterials,
Год журнала:
2024,
Номер
112(2)
Опубликована: Янв. 22, 2024
Abstract
Millions
of
people
have
been
reported
with
tendon
injuries
each
year.
Unfortunately,
Tendon
are
increasing
rapidly
due
to
heavy
exercise
and
a
highly
aging
population.
In
addition,
the
introduction
3D‐printing
technology
in
area
repair
replacement
has
resolved
numerous
issues
significantly
improved
quality
artificial
tendons.
This
advancement
also
enabled
us
explore
identify
most
effective
combinations
biomaterials
that
can
be
utilized
this
field.
review
discusses
recent
development
3D‐printed
tendon;
where
recently,
some
research
investigated
suitable
pore
sizes,
diameter,
strength
for
scaffolds
high
cells
ingrowth
proliferation,
giving
better
understanding
effects
densities
structure
patterns
on
tendon's
mechanical
properties.
it
presents
divergence
between
tendons
other
tissue
how
different
techniques
models
participated
development.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
The
physical
microtopography,
in
an
effective
and
stable
manner,
can
powerfully
confer
biomaterials
with
enhanced
osteoconduction
for
the
repair
of
critical‐sized
bone
defects.
However,
realization
osteoconductive
microtopography
within
a
3D
porous
scaffold
is
still
unmet.
Herein,
this
work
presents
stone‐cottage‐inspired
printing
strategy
to
build
microsphere
patterned
scaffolds
tunable
accelerated
regeneration.
customized
composite
inks
poly
(lactic‐
co
‐glycolic
acid)
microspheres
as
“Stone”
alginate
hydrogels
“Mortar”
endow
fibers
as‐printed
groove‐ridge
microstructure.
Owing
significantly
promote
cell
recruitment,
immune
response,
angiogenesis,
osteogenesis.
Meanwhile,
compared
55
85
µm,
25
µm
width
microstructure
displays
most
critical
Mechanistically,
while
cells
prefer
adhere
bigger
higher
modulus
early
phase,
should
also
act
barrier
growth
its
smaller
more
beneficial
communication
differentiation
later
phase.
Overall,
it
provides
robust
fabricate
scaffold,
broadening
manipulation
morphology
tissue
engineering.
Applied Sciences,
Год журнала:
2025,
Номер
15(5), С. 2301 - 2301
Опубликована: Фев. 21, 2025
Anterior
cruciate
ligament
(ACL)
injuries
pose
significant
challenges,
driving
the
need
for
innovative
repair
strategies.
Tissue
engineering
(TE)
has
emerged
as
a
promising
field
ACL
injuries.
Wet
spinning
is
filament
production
technique
that
enables
precise
control
over
alignment,
diameter,
and
porosity,
making
it
suitable
developing
new
scaffolds
This
study
develops
fibrous
using
wet
of
polycaprolactone
(PCL)
reinforced
with
cellulose
nanocrystals
(CNC)
to
enhance
mechanical
properties.
was
employed
fabricate
scaffolds,
utilizing
PCL
primary
polymer
due
its
favorable
biocompatibility
degradability.
An
automated
collector
developed
optimized,
which
allowed
stretching
filaments
diameters
low
30
µm.
Several
were
explored
characterized
SEM,
TGA,
tests.
The
optimized
PCL/CNC
used
develop
3D
braided
structures
mimic
structure.
combination
wet-spun
(with
an
stirring
method)
braiding
procedure
fully
biocompatible
both
structure
properties
native
ACL.
Cytotoxicity
tests
showed
cell
viability
proliferation
values
above
99%
81%,
respectively.
These
findings
underscore
potential
CNC-reinforced
candidates
repair,
laying
groundwork
future
biomedical
applications.
