Harnessing the power of bee venom for therapeutic and regenerative medical applications: an updated review
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 18, 2024
Honeybees
have
been
helpful
insects
since
ancient
centuries,
and
this
benefit
is
not
limited
to
being
a
honey
producer
only.
After
the
bee
stings
person,
pain,
swelling
occur
in
place,
due
effects
of
venom
(BV).
This
poison
total
sense
word
because
it
has
many
benefits,
its
composition
rich
proteins,
peptides,
enzymes,
other
types
molecules
low
concentrations
that
show
promise
treatment
numerous
diseases
conditions.
BV
also
demonstrated
positive
against
various
cancers,
antimicrobial
activity,
wound
healing
versus
human
immunodeficiency
virus
(HIV).
Even
though
topical
therapy
used
varying
degrees
among
countries,
localized
or
itching
are
common
side
may
some
patients.
review
provides
an
in-depth
analysis
complex
chemical
BV,
highlighting
diverse
range
bioactive
compounds
their
therapeutic
applications,
which
extend
beyond
well-known
anti-inflammatory
pain-relieving
effects,
showcasing
versatility
modern
medicine.
A
specific
search
strategy
was
followed
across
databases;
Web
sciences,
Scopus,
Medline,
Google
Scholar
including
vitro
vivo
clinical
studies.to
outline
overview
composition,
methods
use,
preparation
requirements,
Individual
consumption
contraindications.
Furthermore,
addresses
safety
concerns
emerging
approaches,
such
as
use
nanoparticles,
mitigate
adverse
demonstrating
balanced
holistic
perspective.
Importantly,
incorporates
historical
context
traditional
uses,
well
unique
focus
on
veterinary
setting
apart
from
previous
works
providing
valuable
resource
for
researchers
practitioners
field.
Язык: Английский
Nanodiamond: A Promising Carbon‐Based Nanomaterial for Therapeutic and Regenerative Dental Applications
ChemistrySelect,
Год журнала:
2024,
Номер
9(35)
Опубликована: Сен. 17, 2024
Abstract
Nanodiamonds
(NDs)
are
utilized
for
various
purposes
in
dentistry,
such
as
tissue
regeneration,
gene
therapy,
and
medication
delivery.
Despite
the
examination
of
their
potential
dental
uses,
there
is
currently
no
published
review
summarizing
conducted
investigations.
Additional
investigations
required
to
comprehend
biological
compatibility
NDs
dentistry.
have
been
proven
effective
a
variety
applications
dentistry
because
unique
qualities
target
cell
selectivity,
nanometer
size,
fluorescence.
find
encompassing
roles
directed
reinforcing
polymers,
administering
medications
treating
infections
cancer.
Researchers
also
suggested
use
nanodiamonds
coatings
antibacterial
or
bioactive
implants.
Nevertheless,
on
scarce
insufficient
so
far,
necessitating
significantly
further
studies
envision
It
believed
that
within
ten
years
come,
these
emerging
substances
will
discover
several
kinds
daily
usage
practice.
Язык: Английский
Challenges of therapeutic applications and regenerative capacities of urine based stem cells in oral, and maxillofacial reconstruction
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117005 - 117005
Опубликована: Июнь 29, 2024
Urine-derived
stem
cells
(USCs)
have
gained
the
attention
of
researchers
in
biomedical
field
past
few
years
.
Regarding
several
varieties
that
been
used
for
this
purpose,
USCs
demonstrated
mesenchymal
cell-like
properties,
such
as
differentiation
and
immunomodulation.
Furthermore,
they
could
be
differentiated
into
lineages.
This
is
very
interesting
regenerative
techniques
based
on
cell
therapy.
review
will
embark
describing
their
separation,
profiling.
We
specifically
describe
characteristics,
addition
to
potential.
Then,
we
introduce
explore
primary
uses
USCs.
These
involve
thier
utilization
a
platform
produce
cells,
however,
shall
concentrate
therapeutic,
orofacial
applications,
providing
an
in-depth
evaluation
purpose.
The
final
portion
address
limitations
challenges
implementation
dentistry.
Язык: Английский
Bioactive Functionalized Chitosan Thermo‐Responsive Hydrogels as Promising Platforms for Therapeutic, Regenerative Oral, and Maxillofacial Applications
Biotechnology Journal,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Due
to
their
superior
physicochemical
features,
chitosan
thermosensitive
hydrogels
are
multipurpose
platforms
that
frequently
used
in
the
biomedical
industry.
Many
investigations
have
been
conducted
recently
modify
pore
dimensions,
expansion,
biodegradability,
stimulus‐reaction
characteristics,
and
other
characteristics
order
better
tailor
them
complex
craniofacial
tissues.
They
focus
of
various
studies
attempted
load
biological
cargos
for
therapeutic
regenerative
uses
oro‐facial
This
article
assesses
utility
advancements
hydrogel‐based
pharmaceutical
delivery
devices
management
disorders
such
as
dental
caries,
endodontic
diseases,
periodontitis,
temporomandibular
disorders,
mucosal
cancer,
so
forth.
Язык: Английский
Evaluation of Anti-Inflammatory and Antibacterial Properties of Photo-Thermal Hydrogel as Dual Functional Platform for Management of Periodontitis
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2923 - 2934
Опубликована: Март 1, 2025
Background:
Periodontitis,
one
of
the
most
common
oral
diseases
caused
by
bacterial
infection
which
affects
gums,
periodontal
ligament
and
alveolar
bone,
is
a
leading
cause
tooth
loss
in
adults.
Current
clinical
treatments,
such
as
scaling
or
antibiotics,
often
result
incomplete
biofilm
removal
can
contribute
to
drug
resistance.
Methods:
To
address
these
limitations,
nanozyme
comprising
platinum,
copper,
selenium
was
developed,
then
incorporated
into
thermoresponsive
hydrogel.
Results:
When
applied
pockets
exposed
808
nm
laser
irradiation,
hydrogel
became
soft,
dissolving
release
nanozyme.
This
demonstrated
superoxide
dismutase
(SOD)-like
catalase
(CAT)-like
activity,
reducing
excess
reactive
oxygen
species
(ROS)
while
displaying
strong
antibacterial
anti-inflammatory
effects.
Conclusion:
photothermal
showed
excellent
biocompatibility
has
potential
overcome
challenges
current
periodontitis
treatments.
Keywords:
thermosensitive,
therapy,
hydrogel,
Язык: Английский
Prospective and challenges of locally applied repurposed pharmaceuticals for periodontal tissue regeneration
Mohammad El-Nablaway,
Fatema Rashed,
Ehab S. Taher
и другие.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 13, 2024
Periodontitis
is
a
persistent
inflammatory
condition
that
causes
periodontal
ligament
degradation,
pocket
development,
and
alveolar
bone
destruction,
all
of
which
lead
to
the
breakdown
teeth’s
supporting
system.
triggered
by
accumulation
various
microflora
(especially
anaerobes)
in
pockets,
release
toxic
substances
digestive
enzymes
stimulate
immune
can
be
efficiently
treated
using
variety
techniques,
both
regional
systemic.
Effective
therapy
dependent
on
lowering
microbial
biofilm,
minimizing
or
eradicating
pockets.
Nowadays,
local
drug
delivery
systems
(LDDSs)
as
an
adjuvant
phase
I
attractive
option
since
it
controls
release,
resulting
improved
efficacy
lesser
adverse
reactions.
Choosing
right
bioactive
agent
mode
foundation
efficient
disease
management
approach.
The
objective
this
paper
shed
light
issue
successful
regeneration,
drawbacks
currently
implemented
interventions,
describe
potential
locally
delivered
repurposed
drugs
tissue
regeneration.
Because
multiple
etiology
periodontitis,
patients
must
get
customized
treatment
with
primary
goal
infection
control.
Yet,
not
always
replace
lost
tissues,
becomes
more
challenging
defect
gets
worse.
Pharmaceutical
repurposing
offers
viable,
economical,
safe
alternative
for
non-invasive,
predictable
This
article
clears
way
front
researchers,
decision-makers,
pharmaceutical
companies
explore
potential,
effectiveness,
efficiency
pharmaceuticals
generate
effective,
topical
preparations
Язык: Английский
Emerging Biopolymer Nanocarriers for Controlled and Protective Delivery of Food Bioactive Compounds- Current Status and Future Perspective
Food Hydrocolloids,
Год журнала:
2024,
Номер
160, С. 110769 - 110769
Опубликована: Окт. 22, 2024
Язык: Английский
Application of biomaterials in cardiac tissue engineering: Current status and prospects
MedComm – Biomaterials and Applications,
Год журнала:
2024,
Номер
3(4)
Опубликована: Ноя. 19, 2024
Abstract
Cardiovascular
diseases
have
become
one
of
the
leading
causes
death
and
illness
worldwide,
posing
significant
challenges
to
global
health.
Due
limited
regenerative
capacity
heart,
conventional
approaches
treating
heart
demonstrated
effectiveness.
Therefore,
leveraging
biomaterials
biotechnologies
in
cardiac
tissue
engineering
has
emerged
as
a
promising
therapeutic
strategy.
This
review
aims
summarize
various
characteristics
their
significance
addressing
diseases.
We
categorize
into
natural,
synthetic,
conductive
types
based
on
sources
unique
properties,
focusing
applications
engineering.
then
present
current
engineering,
followed
by
discussion
existing
such
long‐term
material
stability,
biocompatibility,
adverse
reactions,
precise
application
methodologies.
Additionally,
we
provide
insights
potential
strategies
for
overcoming
these
challenges,
aiming
enhance
effectiveness
safety
applications.
Finally,
this
highlights
emerging
technologies,
underscoring
critical
role
interdisciplinary
collaboration
driving
innovation
progress
Язык: Английский