Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(15), С. 2402 - 2445
Опубликована: Июль 17, 2024
Protein-based
wound
dressings
have
garnered
increasing
interest
in
recent
years
owing
to
their
distinct
physical,
chemical,
and
biological
characteristics.
The
intricate
molecular
composition
of
proteins
gives
rise
unique
characteristics,
such
as
exceptional
biocompatibility,
biodegradability,
responsiveness,
which
contribute
the
promotion
healing.
Wound
healing
is
an
ongoing
process
influenced
by
multiple
causes,
it
consists
four
phases.
Various
treatments
been
developed
repair
different
types
skin
wounds,
thanks
advancements
medical
technology
recognition
diverse
nature
wounds.
This
review
has
literature
reviewed
within
last
3-5
years-the
progress
development
protein
fundamental
properties
ideal
dressing.
Herein,
strides
protein-based
state-of-the-art
dressing
emphasize
significant
challenges
summarize
future
perspectives
for
applications.
Hydrogels
are
attractive
biomaterials
with
favorable
characteristics
due
to
their
water
uptake
capacity.
However,
hydrogel
properties
determined
by
the
cross-linking
degree
and
nature,
tacticity,
crystallinity
of
polymer.
These
can
be
sorted
out
according
internal
structure
response
external
factors.
In
this
case,
interaction
reversible
when
chains
led
physicochemical
interactions.
physical
hydrogels
synthesized
through
several
techniques
such
as
crystallization,
amphiphilic
copolymers,
charge
interactions,
hydrogen
bonds,
stereo-complexing,
protein
contrast,
irreversible
covalent
cross-linking.
Synthesized
chemical
interactions
present
a
high
density
employed
using
graft
copolymerization,
reactive
functional
groups,
enzymatic
methods.
Moreover,
specific
smart
have
also
been
denoted
response,
pH,
temperature,
electric,
light,
enzyme.
This
review
deeply
details
type
hydrogel,
either
or
response.
Furthermore,
we
detail
some
main
applications
these
in
biomedicine
field,
drug
delivery
systems,
scaffolds
for
tissue
engineering,
actuators,
biosensors,
many
other
applications.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(7), С. 3665 - 3665
Опубликована: Март 27, 2022
Since
the
last
few
decades,
development
of
smart
hydrogels,
which
can
respond
to
stimuli
and
adapt
their
responses
based
on
external
cues
from
environments,
has
become
a
thriving
research
frontier
in
biomedical
engineering
field.
Nowadays,
drug
delivery
systems
have
received
great
attention
hydrogels
be
potentially
used
these
due
high
stability,
physicochemical
properties,
biocompatibility.
Smart
change
hydrophilicity,
swelling
ability,
physical
molecules
permeability,
influenced
by
such
as
pH,
temperature,
electrical
magnetic
fields,
light,
biomolecules'
concentration,
thus
resulting
controlled
release
loaded
drugs.
Herein,
this
review
encompasses
latest
investigations
field
stimuli-responsive
drug-loaded
our
contribution
matter.
Military Medical Research,
Год журнала:
2023,
Номер
10(1)
Опубликована: Март 28, 2023
Biomimetic
materials
have
emerged
as
attractive
and
competitive
alternatives
for
tissue
engineering
(TE)
regenerative
medicine.
In
contrast
to
conventional
biomaterials
or
synthetic
materials,
biomimetic
scaffolds
based
on
natural
biomaterial
can
offer
cells
a
broad
spectrum
of
biochemical
biophysical
cues
that
mimic
the
in
vivo
extracellular
matrix
(ECM).
Additionally,
such
mechanical
adaptability,
microstructure
interconnectivity,
inherent
bioactivity,
making
them
ideal
design
living
implants
specific
applications
TE
This
paper
provides
an
overview
recent
progress
(BNBMs),
including
advances
their
preparation,
functionality,
potential
future
challenges.
We
highlight
fabrication
BNBMs
outline
general
strategies
functionalizing
tailoring
with
various
biological
physicochemical
characteristics
native
ECM.
Moreover,
we
key
functionalization
versatile
applications.
Finally,
conclude
by
offering
our
perspective
open
challenges
developments
this
rapidly-evolving
field.
Polymer Composites,
Год журнала:
2022,
Номер
43(9), С. 6355 - 6380
Опубликована: Авг. 12, 2022
Abstract
The
latest
developments
in
smart
systems
for
improved
human
lives
with
advanced
biomedical
devices
have
evolved
out
of
multi‐disciplinary
scientific
studies,
including
medicine,
biology,
material
sciences,
design,
manufacturing,
artificial
intelligence,
microelectronics,
and
so
forth.
growth
such
intelligent
is
primarily
possible
innovative
materials,
which
demonstrate
the
response
to
various
external
stimuli
like
temperature,
heat,
moisture,
light,
electromagnetic
field,
chemical
alteration.
Such
materials
been
recently
fabricated
using
different
additive
manufacturing
techniques
devise
personalized
unique,
complex,
novel
structures
that
can
adjust
conditions
over
time
are
specifically
attributed
4D
printing.
Novel
further
improve
continued
be
explored
employed.
This
review
paper
investigates
functional
polymer
nanocomposites,
offer
compliant
flexible
processes
high
strength,
low
cost,
long‐term
stability.
study
aims
deliver
a
comprehensive
deep
understanding
fundamental
mechanisms
involved,
future
possibilities
this
area
research.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Abstract
Deregulated
inflammations
induced
by
various
factors
are
one
of
the
most
common
diseases
in
people's
daily
life,
while
severe
inflammation
can
even
lead
to
death.
Thus,
efficient
treatment
has
always
been
hot
topic
research
medicine.
In
past
decades,
as
a
potential
biomaterial,
stimuli‐responsive
hydrogels
have
focus
attention
for
due
their
excellent
biocompatibility
and
design
flexibility.
Recently,
thanks
rapid
development
nanotechnology
material
science,
more
efforts
made
develop
safer,
personal
effective
therapy
some
frequent
but
tough
such
sepsis,
rheumatoid
arthritis,
osteoarthritis,
periodontitis,
ulcerative
colitis.
Herein,
from
recent
studies
articles,
conventional
emerging
delivery
anti‐inflammatory
drugs
summarized.
And
prospects
clinical
translation
future
also
discussed
further
detail.
This
review
summarizes
the
fundamental
concepts,
recent
advancements,
and
emerging
trends
in
field
of
stimuli-responsive
hydrogels.
While
numerous
reviews
exist
on
this
topic,
continues
to
evolve
dynamically,
certain
research
directions
are
often
overlooked.
To
address
this,
we
classify
hydrogels
based
their
response
mechanisms
provide
an
in-depth
discussion
key
properties
mechanisms,
including
swelling
kinetics,
mechanical
properties,
biocompatibility/biodegradability.
We
then
explore
hydrogel
design,
synthesis,
structural
engineering,
followed
by
overview
applications
that
relatively
well
established
from
a
scientific
perspective,
biomedical
uses
(biosensing,
drug
delivery,
wound
healing,
tissue
engineering),
environmental
(heavy
metal
phosphate
removal
environment
polluted
water),
soft
robotics
actuation.
Additionally,
highlight
unconventional
such
as
local
micro-thermometers
cell
mechanotransduction.
concludes
with
current
challenges
future
prospects
field,
aiming
inspire
further
innovations
advancements
bring
them
closer
societal
needs.
Advanced Materials,
Год журнала:
2022,
Номер
34(38)
Опубликована: Май 18, 2022
Abstract
Globally,
liver
cancer,
which
is
one
of
the
major
cancers
worldwide,
has
attracted
growing
attention
technological
researchers
for
its
high
mortality
and
limited
treatment
options.
Hydrogels
are
soft
3D
network
materials
containing
a
large
number
hydrophilic
monomers.
By
adding
moieties
such
as
nitrobenzyl
groups
to
structure
cross‐linked
nanocomposite
hydrogel,
click
reaction
improves
drug‐release
efficiency
in
vivo,
survival
rate
prolongs
time
cancer
patients.
The
application
hydrogel
drug
delivery
system
can
not
only
enrich
concentration
at
tumor
site
long
but
also
effectively
prevents
distant
metastasis
residual
cells.
At
present,
researches
have
been
working
toward
construction
responsive
systems,
there
few
comprehensive
articles
systematically
summarize
these
discoveries.
Here,
this
systematic
review
summarizes
synthesis
methods
related
applications
hydrogels
with
actions
external
or
internal
physiological
stimuli.
With
different
physical
chemical
stimuli,
structural
unit
rearrangement
controlled
release
drugs
be
used
states.
