Biomaterials Advances, Год журнала: 2022, Номер 136, С. 212799 - 212799
Опубликована: Апрель 11, 2022
Язык: Английский
Gels, Год журнала: 2021, Номер 7(4), С. 182 - 182
Опубликована: Окт. 25, 2021
Hydrogels are attractive biomaterials with favorable characteristics due to their water uptake capacity. However, hydrogel properties determined by the cross-linking degree and nature, tacticity, crystallinity of polymer. These can be sorted out according internal structure response external factors. In this case, interaction reversible when chains led physicochemical interactions. physical hydrogels synthesized through several techniques such as crystallization, amphiphilic copolymers, charge interactions, hydrogen bonds, stereo-complexing, protein contrast, irreversible covalent cross-linking. Synthesized chemical interactions present a high density employed using graft copolymerization, reactive functional groups, enzymatic methods. Moreover, specific smart have also been denoted response, pH, temperature, electric, light, enzyme. This review deeply details type hydrogel, either or response. Furthermore, we detail some main applications these in biomedicine field, drug delivery systems, scaffolds for tissue engineering, actuators, biosensors, many other applications.
Язык: Английский
Процитировано
227
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 3665 - 3665
Опубликована: Март 27, 2022
Since the last few decades, development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from environments, has become a thriving research frontier in biomedical engineering field. Nowadays, drug delivery systems have received great attention hydrogels be potentially used these due high stability, physicochemical properties, biocompatibility. Smart change hydrophilicity, swelling ability, physical molecules permeability, influenced by such as pH, temperature, electrical magnetic fields, light, biomolecules' concentration, thus resulting controlled release loaded drugs. Herein, this review encompasses latest investigations field stimuli-responsive drug-loaded our contribution matter.
Язык: Английский
Процитировано
223
Military Medical Research, Год журнала: 2023, Номер 10(1)
Опубликована: Март 28, 2023
Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering (TE) regenerative medicine. In contrast to conventional biomaterials or synthetic materials, biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical biophysical cues that mimic the in vivo extracellular matrix (ECM). Additionally, such mechanical adaptability, microstructure interconnectivity, inherent bioactivity, making them ideal design living implants specific applications TE This paper provides an overview recent progress (BNBMs), including advances their preparation, functionality, potential future challenges. We highlight fabrication BNBMs outline general strategies functionalizing tailoring with various biological physicochemical characteristics native ECM. Moreover, we key functionalization versatile applications. Finally, conclude by offering our perspective open challenges developments this rapidly-evolving field.
Язык: Английский
Процитировано
203
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Июль 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Язык: Английский
Процитировано
109
Polymer Composites, Год журнала: 2022, Номер 43(9), С. 6355 - 6380
Опубликована: Авг. 12, 2022
Abstract The latest developments in smart systems for improved human lives with advanced biomedical devices have evolved out of multi‐disciplinary scientific studies, including medicine, biology, material sciences, design, manufacturing, artificial intelligence, microelectronics, and so forth. growth such intelligent is primarily possible innovative materials, which demonstrate the response to various external stimuli like temperature, heat, moisture, light, electromagnetic field, chemical alteration. Such materials been recently fabricated using different additive manufacturing techniques devise personalized unique, complex, novel structures that can adjust conditions over time are specifically attributed 4D printing. Novel further improve continued be explored employed. This review paper investigates functional polymer nanocomposites, offer compliant flexible processes high strength, low cost, long‐term stability. study aims deliver a comprehensive deep understanding fundamental mechanisms involved, future possibilities this area research.
Язык: Английский
Процитировано
92
Journal of Molecular Liquids, Год журнала: 2022, Номер 366, С. 120303 - 120303
Опубликована: Сен. 9, 2022
Язык: Английский
Процитировано
76
Advanced Science, Год журнала: 2023, Номер 11(1)
Опубликована: Ноя. 20, 2023
Abstract Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, efficient treatment has always been hot topic research medicine. In past decades, as a potential biomaterial, stimuli‐responsive hydrogels have focus attention for due their excellent biocompatibility and design flexibility. Recently, thanks rapid development nanotechnology material science, more efforts made develop safer, personal effective therapy some frequent but tough such sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, ulcerative colitis. Herein, from recent studies articles, conventional emerging delivery anti‐inflammatory drugs summarized. And prospects clinical translation future also discussed further detail.
Язык: Английский
Процитировано
55
Gels, Год журнала: 2025, Номер 11(1), С. 30 - 30
Опубликована: Янв. 2, 2025
This review summarizes the fundamental concepts, recent advancements, and emerging trends in field of stimuli-responsive hydrogels. While numerous reviews exist on this topic, continues to evolve dynamically, certain research directions are often overlooked. To address this, we classify hydrogels based their response mechanisms provide an in-depth discussion key properties mechanisms, including swelling kinetics, mechanical properties, biocompatibility/biodegradability. We then explore hydrogel design, synthesis, structural engineering, followed by overview applications that relatively well established from a scientific perspective, biomedical uses (biosensing, drug delivery, wound healing, tissue engineering), environmental (heavy metal phosphate removal environment polluted water), soft robotics actuation. Additionally, highlight unconventional such as local micro-thermometers cell mechanotransduction. concludes with current challenges future prospects field, aiming inspire further innovations advancements bring them closer societal needs.
Язык: Английский
Процитировано
8
Advanced Materials, Год журнала: 2022, Номер 34(38)
Опубликована: Май 18, 2022
Abstract Globally, liver cancer, which is one of the major cancers worldwide, has attracted growing attention technological researchers for its high mortality and limited treatment options. Hydrogels are soft 3D network materials containing a large number hydrophilic monomers. By adding moieties such as nitrobenzyl groups to structure cross‐linked nanocomposite hydrogel, click reaction improves drug‐release efficiency in vivo, survival rate prolongs time cancer patients. The application hydrogel drug delivery system can not only enrich concentration at tumor site long but also effectively prevents distant metastasis residual cells. At present, researches have been working toward construction responsive systems, there few comprehensive articles systematically summarize these discoveries. Here, this systematic review summarizes synthesis methods related applications hydrogels with actions external or internal physiological stimuli. With different physical chemical stimuli, structural unit rearrangement controlled release drugs be used states.
Язык: Английский
Процитировано
53
European Polymer Journal, Год журнала: 2022, Номер 177, С. 111473 - 111473
Опубликована: Авг. 1, 2022
Язык: Английский
Процитировано
52