Mesoporous silica nanoparticles with chiral pattern topological structure function as “antiskid tires” on the intestinal mucosa to facilitate oral drugs delivery DOI Creative Commons
Xin Wei, Lin Wang,

Jiahui Lin

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 18(2), С. 100795 - 100795

Опубликована: Фев. 25, 2023

The weak adhesion between nanocarriers and the intestinal mucosa was one of main reasons caused failure in oral delivery. Inspired by "antiskid tires" with complex chiral patterns, mesoporous silica nanoparticles AT-R@CMSN exhibiting geometrical structure were designed to improve surface/interface roughness nanoscale, employed as hosting system for insoluble drugs nimesulide (NMS) ibuprofen (IBU). Once performing delivery tasks, rigid skeleton protected loaded drug reduced irritation on gastrointestinal tract (GIT), while their porous deprived crystal improved release. More importantly, functioned tire" produce higher friction substantively influenced multiple biological processes, including "contact", "adhesion", "retention", "permeation" "uptake", compared achiral S@MSN, thereby improving adsorption effectiveness such systems. By engineering overcome stability, solubility permeability bottlenecks drugs, orally administered NMS or IBU could achieve relative bioavailability (705.95% 444.42%, respectively) stronger anti-inflammation effect. In addition, displayed favorable biocompatibility biodegradability. Undoubtedly, present finding helped understand process nanocarriers, provided novel insights into rational design nanocarriers.

Язык: Английский

A platinum(IV)–artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy DOI Creative Commons

Renming Fan,

Aohua Deng,

Ruizhuo Lin

и другие.

MedComm, Год журнала: 2024, Номер 5(6)

Опубликована: Май 20, 2024

Abstract Ferroptosis is an iron‐dependent cell death form that initiates lipid peroxidation (LPO) in tumors. In recent years, there has been growing interest on ferroptosis, but how to propel it forward translational medicine remains mist. Although experimental ferroptosis inducers such as RSL3 and erastin have demonstrated bioactivity vitro, the poor antitumor outcome animal model limits their development. this study, we reveal a novel inducer, oxaliplatin–artesunate (OART), which exhibits substantial vitro vivo, verify its feasibility cancer immunotherapy. For mechanism, OART induces cytoplasmic mitochondrial LPO promote tumor via inhibiting glutathione‐mediated defense system, enhancing Fenton reaction, initiating LPO. The destroyed membrane potential, disturbed fusion fission, well downregulation of dihydroorotate dehydrogenase mutually contribute Consequently, enhances immunogenicity by releasing damage associated molecular patterns promoting antigen presenting cells maturation, thereby transforming environment from immunosuppressive immunosensitive. By establishing vivo tumorigenesis lung metastasis, verified improves systematic immune response. summary, enormous clinical potential for ferroptosis‐based therapy medicine.

Язык: Английский

Процитировано

7
Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment DOI

Liyun Zhu,

Danni Meng,

Xu Wang

и другие.

ACS Applied Bio Materials, Год журнала: 2022, Номер 5(6), С. 2481 - 2506

Опубликована: Май 26, 2022

Ferroptosis, characterized by iron-dependent lipid reactive oxygen species (ROS) accumulation, is non-apoptotic programmed cell death highly relevant to tumor development. It was found manipulate oncogenes and resistant mutations of cancer cells via metabolism pathways converging on phospholipid glutathione peroxidase (GPX4) that squanders peroxides (L-OOH) block the iron-mediated reactions peroxides, thus rendering vulnerable ferroptotic death. By accumulating ROS peroxidation (LPO) products lethal levels in microenvironment (TME), ferroptosis-driven nanotherapeutics show a superior ability eradicating aggressive malignancies than traditional therapeutic modalities, especially for drug-resistant tumors with high metastasis tendency. Moreover, Fenton reaction, inhibition GPX-4, exogenous regulation LPO are three major strategies induce ferroptosis cells, which were generally applied nanotherapeutics. In this review, we elaborate current trends reverse drug resistance anticancer fields at intersection biology, materials science, chemistry. Finally, their challenges perspectives toward feasible translational studies spotlighted, would ignite hope anti-resistant treatment.

Язык: Английский

Процитировано

24
Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors DOI Creative Commons
Yansheng Yao, Peng Ji, Hao Chen

и другие.

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Фев. 23, 2023

The brain tumor is a kind of malignant with brutal treatment, high recurrence rate, and poor prognosis, the incidence death rate increasing yearly. Surgery often used to remove primary tumor, supplemented by radiotherapy chemotherapy, which have highly toxic side effects. Therefore, there an urgent need explore new strategies, methods, technologies that can genuinely improve treatment tumors. Ferroptosis differs from traditional apoptosis’s morphological biochemical characteristics, ferroptosis possesses its unique characteristics mechanisms, opening up field for cancer. It has been found close relationship between tumors, novel nano-drug delivery system based on tumors remarkable This review firstly analyzes ferroptosis, summarizes mechanism occurrence some factors be involved in regulation introduces potential link clarifies feasibility then presents nano drug systems developed under different metabolic pathways Finally, it current problems solutions drugs aiming provide reference developing against

Язык: Английский

Процитировано

15
Multifunctional nanocomposites induce mitochondrial dysfunction and glucose deprivation to boost immunogenic ferroptosis for cancer therapy DOI
Cong Huang,

Xiaosheng Lin,

Teng Chiu Lin

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 466, С. 143012 - 143012

Опубликована: Апрель 18, 2023

Язык: Английский

Процитировано

15
Multifunctional Fe3O4-PEI@HA nanoparticles in the ferroptosis treatment of hepatocellular carcinoma through modulating reactive oxygen species DOI
Ziwei Liang, Yuhui Wang, Jiapu Wang

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2023, Номер 227, С. 113358 - 113358

Опубликована: Май 17, 2023

Язык: Английский

Процитировано

14
Advances in PD-1 signaling inhibition-based nano-delivery systems for tumor therapy DOI Creative Commons

Songlin Liu,

Haiyang Wang,

Xinzhe Shao

и другие.

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Июль 4, 2023

Abstract In recent years, cancer immunotherapy has emerged as an exciting treatment. Immune checkpoint blockade brings new opportunities for more researchers and clinicians. Programmed cell death receptor-1 (PD-1) is a widely studied immune checkpoint, PD-1 therapy shown promising results in variety of tumors, including melanoma, non-small lung renal carcinoma, which greatly improves patient overall survival becomes tool the eradication metastatic or inoperable tumors. However, low responsiveness immune-related adverse effects currently limit its clinical application. Overcoming these difficulties major challenge to improve therapies. Nanomaterials have unique properties that enable targeted drug delivery, combination through multidrug co-delivery strategies, controlled release sensitive bonds construction. combining nanomaterials with construct novel single-drug-based therapy-based nano-delivery systems become effective mean address limitations therapy. this study, application nanomaterial carriers individual delivery inhibitors, combined inhibitors other immunomodulators, chemotherapeutic drugs, photothermal reagents were reviewed, provides references designing therapeutic strategies. Graphical

Язык: Английский

Процитировано

13
Blood brain barrier-targeted delivery of double selenium nanospheres ameliorates neural ferroptosis in Alzheimer's disease DOI Creative Commons
Jingyuan Wang, Zekun Wang, Yuqing Li

и другие.

Biomaterials, Год журнала: 2023, Номер 302, С. 122359 - 122359

Опубликована: Окт. 22, 2023

Alzheimer's disease (AD) as a common neurodegenerative showed progressive cognitive dysfunction and behavioral impairment. Currently, the deposition of amyloid β-protein (Aβ) remains main pathomechanism. However, preventing neuronal death induced by Aβ elusive, no effective strategy in clinic was found to combat AD. Herein, multifunctional double selenium nanosphere (CLNDSe) designed prepared, A

Язык: Английский

Процитировано

12
Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy DOI

Jiangshan Xu,

Weifei Zhang, Zhengwen Cai

и другие.

Chinese Chemical Letters, Год журнала: 2024, Номер 35(11), С. 109620 - 109620

Опубликована: Фев. 13, 2024

Язык: Английский

Процитировано

5
A glutathione-responsive sulfur dioxide polymer prodrug selectively induces ferroptosis in gastric cancer therapy DOI

Mingjie Xia,

Zhihui Guo, Xinming Liu

и другие.

Biomaterials Science, Год журнала: 2022, Номер 10(15), С. 4184 - 4192

Опубликована: Янв. 1, 2022

Nanoparticle-induced ferroptosis has been proven to be an appealing strategy in cancer treatment. Previously, we reported the synthesis of amphiphilic polymer prodrug SO2, mPEG-PLG(DNs), which could self-assemble formulate nanoparticles (NP-DNs) and trigger cell death by GSH consumption SO2 release. In current study, potential mechanism NP-DNs-induced was further investigated. We demonstrated that NP-DNs exhibited efficient antitumor activity against gastric via ferroptosis. selectively accelerate lipid peroxidation through depletion generation cells. addition, GPX4 reduction played a collaborative role Concurrently, vivo evaluations revealed not only excellent efficiency but also caused little systemic toxicity mice. All results showed would promising precision-targeted therapy.

Язык: Английский

Процитировано

18
Synergistic Amplification of Ferroptosis with Liposomal Oxidation Catalyst and Gpx4 Inhibitor for Enhanced Cancer Therapy DOI
Ye Yuan,

Chunyu Tian,

Qi Wang

и другие.

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(28)

Опубликована: Июль 17, 2023

As a distinctly different way from apoptosis, ferroptosis can cause cell death through excessive accumulation of lipid peroxide (LPO) and show great potential for cancer therapy. However, efficient strategies therapy are still facing challenges, mainly due to insufficient endogenous H2 O2 or relatively high pH value Fenton reaction-dependent ferroptosis, the redox level tumor cells attenuates oxidation Herein, an lipid-based delivery system load catalyst glutathione peroxidase 4 (Gpx4) inhibitor is orchestrated, intending amplify reaction-independent by bidirectional regulation LPO accumulation. Ferric ammonium citrate (FAC), Gpx4 sorafenib (SF), unsaturated lipids constructed into mPEG2K -DSPE-modified liposomes (Lip@SF&FAC). Influenced intratumoral glutathione, FAC be converted Fe2+ , subsequently formed iron pair (Fe2+ /Fe3+ ) catalyzes phospholipids via manner. Meanwhile, SF downregulate reduction inhibiting activation. In vitro in vivo antitumor experiments that Lip@SF&FAC induces massive ultimately exhibits strong tumor-killing ability with negligible side effect. Consequently, this two-pronged approach provides new strategy predominant enhanced

Язык: Английский

Процитировано

11