Silk chemistry and biomedical material designs

Nature Reviews Chemistry, Год журнала: 2023, Номер 7(5), С. 302 - 318

Опубликована: Апрель 21, 2023

Язык: Английский

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Recent advances in biopolymer-based hydrogels and their potential biomedical applications

Carbohydrate Polymers, Год журнала: 2023, Номер 323, С. 121408 - 121408

Опубликована: Сен. 17, 2023

Язык: Английский

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Silk fibroin hydrogels for biomedical applications

Smart Medicine, Год журнала: 2022, Номер 1(1)

Опубликована: Дек. 1, 2022

Silk fibroin hydrogels occupy an essential position in the biomedical field due to their remarkable biological properties, excellent mechanical flexible processing as well abundant sources and low cost. Herein, we introduce unique structures physicochemical characteristics of silk fibroin, including biocompatibility, biodegradability. Then, various preparation strategies are summarized, which can be divided into physical cross-linking chemical cross-linking. Emphatically, applications hydrogel biomaterials fields, tissue engineering, drug delivery, wearable sensors, systematically summarized. At last, challenges future prospects discussed.

Язык: Английский

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Progress and prospects of polysaccharide-based nanocarriers for oral delivery of proteins/peptides

Carbohydrate Polymers, Год журнала: 2023, Номер 312, С. 120838 - 120838

Опубликована: Март 24, 2023

Язык: Английский

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Stabilization challenges and aggregation in protein-based therapeutics in the pharmaceutical industry

RSC Advances, Год журнала: 2023, Номер 13(51), С. 35947 - 35963

Опубликована: Янв. 1, 2023

Protein-based therapeutics have revolutionized the pharmaceutical industry and become vital components in development of future therapeutics. They offer several advantages over traditional small molecule drugs, including high affinity, potency specificity, while demonstrating low toxicity minimal adverse effects. However, manufacturing processes protein-based presents challenges related to protein folding, purification, stability immunogenicity that should be addressed. These proteins, like other biological molecules, are prone chemical physical instabilities. The drugs throughout entire manufacturing, storage delivery process is essential. occurrence structural instability resulting from misfolding, unfolding, modifications, as well aggregation, poses a significant risk efficacy these overshadowing their promising attributes. Gaining insight into alterations caused by aggregation impact on for advancement refinement Hence, this review, we discussed some features during production, formulation stabilization strategies engineering computational methods prevent aggregation.

Язык: Английский

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Silk Fibroin Microneedles for Transdermal Drug Delivery: Where Do We Stand and How Far Can We Proceed?

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 355 - 355

Опубликована: Янв. 20, 2023

Microneedles are a patient-friendly technique for delivering drugs to the site of action in place traditional oral and injectable administration. Silk fibroin represents an interesting polymeric biomaterial because its mechanical properties, thermal stability, biocompatibility possibility control via genetic engineering. This review focuses on critical research progress silk microneedles since their inception, analyzes detail structure properties fibroin, types microneedles, drug delivery applications clinical trials, summarizes future development trend this field. It also proposes direction including increasing loading doses enriching as well exploring with stimulation-responsive release functions. The safety effectiveness should be further verified trials at different stages.

Язык: Английский

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Anti-inflammatory peptide therapeutics and the role of sulphur containing amino acids (cysteine and methionine) in inflammation suppression: A review

Inflammation Research, Год журнала: 2024, Номер 73(7), С. 1203 - 1221

Опубликована: Май 21, 2024

Язык: Английский

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Covalent conjugation and non-covalent complexation strategies for intracellular delivery of proteins using cell-penetrating peptides

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116910 - 116910

Опубликована: Июнь 8, 2024

Therapeutic proteins provided new opportunities for patients and high sales volumes. However, they are formulated extracellular targets. The lipophilic barrier of the plasma membrane renders vast array intracellular targets out reach. Peptide-based delivery systems, namely cell-penetrating peptides (CPPs), have few safety concerns, low immunogenicity, with control over administered doses. This study investigates CPP-based protein systems by classifying them into CPP-protein "covalent conjugation" CPP: "non-covalent complexation" categories. Covalent conjugates ensure proximity CPP to cargo, which can improve cellular uptake endosomal escape. We will discuss various aspects covalent through non-cleavable (stable) or cleavable bonds. Non-cleavable produced recombinant DNA technology express complete fusion in a host cell chemical ligation protein, ensures stability during process. bonds classified pH-sensitive redox-sensitive bonds, enzyme-cleavable physical stimuli linkers (light radiation, ultrasonic waves, thermo-responsive). highlighted key characteristics non-covalent complexes electrostatic hydrophobic interactions preserve conformational integrity cargo. CPP-mediated complexation, such as zippers, adaptor methods, avidin-biotin technology, featured. Conclusively, complexation methods appropriate when number samples be screened. In contrast, biological activity is critical compartment, conjugation protocols preferred.

Язык: Английский

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Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy

Nano Convergence, Год журнала: 2024, Номер 11(1)

Опубликована: Апрель 18, 2024

Abstract Nanomedicine has been extensively explored for therapeutic and diagnostic applications in recent years, owing to its numerous advantages such as controlled release, targeted delivery, efficient protection of encapsulated agents. Integration microneedle technologies with nanomedicine the potential address current limitations drug delivery including relatively low efficacy poor patient compliance enable theragnostic uses. In this Review, we first summarize representative types describe their broad applications. We then outline challenges faced by nanomedicine, a focus on issues related physical barriers, biological compliance. Next, provide an overview systems, definition, manufacturing strategies, release mechanisms, challenges. also discuss use microneedle-mediated systems Finally, perspective status future prospects biomedical

Язык: Английский

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Bacterial Systems as a Precision Delivery Platform of Therapeutic Peptides for Cancer Therapy

Polymer science & technology., Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский

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