Biomimetic selenium nanosystems for infectious wound healing DOI Creative Commons

Mengkun Fang,

Han Zhang,

Yuze Wang

и другие.

Engineered Regeneration, Год журнала: 2023, Номер 4(2), С. 152 - 160

Опубликована: Фев. 2, 2023

Bacteria-related wound infection and healing have been a major issue for patients health-care systems decades. The rise evolution of effective treatment will result in significant benefits to human beings. In addition standard antibacterial drugs, combination nanoparticles (NPs) biological membranes is widely applied as novel agent against infectious pathogens. this paper, the red blood cell membrane-encapsulated selenium (R-SeNPs) were fabricated healing. stability, immune evading capability, internal circulation time R-SeNPs notably enhanced compared with those bare (SeNPs). Moreover, vivo studies demonstrated outstanding performance biomimetic nanosystem nanotechnology bionics design contribute future.

Язык: Английский

Polymer-based responsive structural color materials DOI
Huan Wang, Hui Zhang, Zhuoyue Chen

и другие.

Progress in Materials Science, Год журнала: 2023, Номер 135, С. 101091 - 101091

Опубликована: Фев. 10, 2023

Язык: Английский

Процитировано

98

Electrospun fiber‐based immune engineering in regenerative medicine DOI Creative Commons

Yiru Xu,

Qimanguli Saiding, Xue Zhou

и другие.

Smart Medicine, Год журнала: 2024, Номер 3(1)

Опубликована: Фев. 1, 2024

Abstract Immune engineering, a burgeoning field within regenerative medicine, involves spectrum of strategies to optimize the intricate interplay between tissue biomaterials and host tissue. These are applied across different types various disease models, which encompasses finely modulating immune response at levels cells factors, aiming mitigate adverse effects like fibrosis persistent inflammation that may arise injury site consequently promote regeneration. With continuous progress in electrospinning technology, immunoregulatory capabilities electrospun fibers have gained substantial attention over years. Electrospun fibers, with their extracellular matrix‐like characteristics, high surface‐area‐to‐volume ratio, reliable pharmaceutical compound capacity, emerged as key players among engineering materials. This review specifically focuses on role fiber‐based emphasizing unique design strategies. Notably, actively engages by responses through four essential strategies: (i) surface modification, (ii) drug loading, (iii) physicochemical parameters, (iv) biological grafting. presents comprehensive overview mechanisms system injured tissues while unveiling adopted orchestrate regulation. Furthermore, explores current developmental trends limitations concerning function drive advancements its full potential.

Язык: Английский

Процитировано

75

Assessment of wound healing activity in diabetic mice treated with a novel therapeutic combination of selenium nanoparticles and platelets rich plasma DOI Creative Commons

Rania A. Karas,

Shaimaa M. I. Alexeree, Hassan Elsayed

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 4, 2024

Abstract Diabetic wound healing is sluggish, often ending in amputations. This study tested a novel, two-punch therapy mice—Selenium nanoparticles (Se NPs) and platelet-rich plasma (PRP)—to boost healing. First, mouse model of diabetes was created. Then, Se NPs were crafted for their impressive antioxidant antimicrobial powers. PRP, packed with growth factors, extracted from the mice's blood. Wound tracked 28 days through photos, scoring tools, tissue analysis. alone spurred healing, PRP added extra fuel. Furthermore, when used combination process accelerated due to higher concentration factors PRP. Notably, exhibited synergistic effect, significantly enhancing diabetic mice. These findings hold promise treatment wounds have potential reduce need lower limb amputations associated foot ulcers. The innovative using shows great expediting addressing challenges impaired individuals diabetes. exciting finding suggests this could change management, potentially saving limbs improving lives.

Язык: Английский

Процитировано

19

Organic–inorganic composite hydrogels: compositions, properties, and applications in regenerative medicine DOI
Xinyu Wang, Wei Wei, Ziyi Guo

и другие.

Biomaterials Science, Год журнала: 2024, Номер 12(5), С. 1079 - 1114

Опубликована: Янв. 1, 2024

Hydrogels, formed from crosslinked hydrophilic macromolecules, provide a three-dimensional microenvironment that mimics the extracellular matrix. They served as scaffold materials in regenerative medicine with an ever-growing demand. However, hydrogels composed of only organic components may not fully meet performance and functionalization requirements for various tissue defects. Composite hydrogels, containing inorganic components, have attracted tremendous attention due to their unique compositions properties. Rigid particles, rods, fibers,

Язык: Английский

Процитировано

18

Photo-/thermo-responsive bioink for improved printability in extrusion-based bioprinting DOI Creative Commons
Seo Hyung Moon, Tae Yoon Park, Hyung Joon

и другие.

Materials Today Bio, Год журнала: 2024, Номер 25, С. 100973 - 100973

Опубликована: Янв. 26, 2024

Extrusion-based bioprinting has demonstrated significant potential for manufacturing constructs, particularly 3D cell culture. However, there is a greatly limited number of bioink candidates exploited with extrusion-based bioprinting, as they meet the opposing requirements printability indispensable rheological features and biochemical functionality desirable microenvironment. In this study, blend silk fibroin (SF) iota-carrageenan (CG) was chosen cell-friendly printable material. The SF/CG ink exhibited suitable viscosity shear-thinning properties, coupled rapid sol-gel transition CG. By employing photo-crosslinking SF, Pr value close to 1 structural integrity constructs were significantly improved within matter seconds. printed Young's modulus approximately 250 kPa, making them keratinocyte myoblast Furthermore, high adhesiveness viability (maximum >98%) loaded cells underscored considerable culture scaffold applied skin muscle tissues, which can be easily manipulated using an bioprinter.

Язык: Английский

Процитировано

18

Cell Membrane-derived Nanovesicles as Extracellular Vesicle-mimetics in Wound Healing DOI Creative Commons
Wen Li, Huihui Zhang, Lianglong Chen

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101595 - 101595

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

5

Review on application of silk fibroin hydrogels in the management of wound healing DOI

Chang Kuk You,

C. Wang,

Zhenjiang Ma

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 298, С. 140082 - 140082

Опубликована: Янв. 18, 2025

Язык: Английский

Процитировано

4

Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care DOI Open Access

Adina Alberts,

Elena-Theodora Moldoveanu,

Adelina-Gabriela Niculescu

и другие.

Journal of Composites Science, Год журнала: 2025, Номер 9(3), С. 133 - 133

Опубликована: Март 13, 2025

Severe skin injuries such as burns and chronic wounds are a subject of interest in the medical field, they require much attention. These types susceptible to serious complications, which can worsen health patients reduce their quality life. Hydrogels have emerged innovative wound dressings for treating acute wounds, including burns, diabetic foot ulcers, venous leg pressure ulcers. polymeric networks provide moist environment, promote cellular migration, offer antimicrobial properties, being recognized superior conventional dressings. This review aims explore recent advancements hydrogel-based dressings, emphasizing state-of-the-art technologies used this purpose trend achieving personalized therapeutic approaches. Despite promising vitro vivo findings described review, further clinical validation large-scale manufacturing optimizations required widespread adoption.

Язык: Английский

Процитировано

4

Progress in regulating inflammatory biomaterials for intervertebral disc regeneration DOI Creative Commons

Honglin Xiang,

Weikang Zhao,

Ke Jiang

и другие.

Bioactive Materials, Год журнала: 2023, Номер 33, С. 506 - 531

Опубликована: Дек. 8, 2023

Intervertebral disc degeneration (IVDD) is rising worldwide and leading to significant health issues financial strain for patients. Traditional treatments IVDD can alleviate pain but do not reverse disease progression, surgical removal of the damaged may be required advanced disease. The inflammatory microenvironment a key driver in development degeneration. Suitable anti-inflammatory substances are critical controlling inflammation IVDD. Several treatment options, including glucocorticoids, non-steroidal drugs, biotherapy, being studied their potential reduce inflammation. However, anti-inflammatories often have short half-life when applied directly quickly excreted, thus limiting therapeutic effects. Biomaterial-based platforms explored as anti-inflammation strategies treatment. This review introduces pathophysiology discusses therapeutics components these unique biomaterial comprehensive systems. We discuss strengths, shortcomings, prospects various biomaterials used modulate microenvironment, providing guidance future breakthroughs

Язык: Английский

Процитировано

38

Engineering multifunctional adhesive hydrogel patches for biomedical applications DOI Creative Commons
Aishik Chakraborty,

Shana Alexander,

Wei Luo

и другие.

Deleted Journal, Год журнала: 2023, Номер 1(4)

Опубликована: Авг. 18, 2023

Abstract Traditional patches, such as sticking plaster or acrylic adhesives used for over a hundred years, lack functionality. To address this issue of poor functionality, adhesive hydrogel patches have emerged an efficient bioactive multifunctional alternative. Hydrogels are three‐dimensional, water‐swellable, and polymeric materials closely resembling the native tissue architecture. The physicochemical properties hydrogels can be modified easily, allowing them to suitable various biomedical applications. Moreover, imparted through manipulations, making ideal candidates supplementing replacing traditional plaster. As result, sticky widely transdermal drug delivery even found commercial purposes. Beyond delivery, also applications in cardiac therapy, cancer research, biosensing, among other In mini‐review, we critically discuss challenges fabricating patches. Furthermore, introduce some chemical strategies involved with We review their emerging Finally, explore potential future flourishing field engineering delivery.

Язык: Английский

Процитировано

34