Engineered Regeneration,
Год журнала:
2023,
Номер
4(2), С. 152 - 160
Опубликована: Фев. 2, 2023
Bacteria-related
wound
infection
and
healing
have
been
a
major
issue
for
patients
health-care
systems
decades.
The
rise
evolution
of
effective
treatment
will
result
in
significant
benefits
to
human
beings.
In
addition
standard
antibacterial
drugs,
combination
nanoparticles
(NPs)
biological
membranes
is
widely
applied
as
novel
agent
against
infectious
pathogens.
this
paper,
the
red
blood
cell
membrane-encapsulated
selenium
(R-SeNPs)
were
fabricated
healing.
stability,
immune
evading
capability,
internal
circulation
time
R-SeNPs
notably
enhanced
compared
with
those
bare
(SeNPs).
Moreover,
vivo
studies
demonstrated
outstanding
performance
biomimetic
nanosystem
nanotechnology
bionics
design
contribute
future.
Abstract
Immune
engineering,
a
burgeoning
field
within
regenerative
medicine,
involves
spectrum
of
strategies
to
optimize
the
intricate
interplay
between
tissue
biomaterials
and
host
tissue.
These
are
applied
across
different
types
various
disease
models,
which
encompasses
finely
modulating
immune
response
at
levels
cells
factors,
aiming
mitigate
adverse
effects
like
fibrosis
persistent
inflammation
that
may
arise
injury
site
consequently
promote
regeneration.
With
continuous
progress
in
electrospinning
technology,
immunoregulatory
capabilities
electrospun
fibers
have
gained
substantial
attention
over
years.
Electrospun
fibers,
with
their
extracellular
matrix‐like
characteristics,
high
surface‐area‐to‐volume
ratio,
reliable
pharmaceutical
compound
capacity,
emerged
as
key
players
among
engineering
materials.
This
review
specifically
focuses
on
role
fiber‐based
emphasizing
unique
design
strategies.
Notably,
actively
engages
by
responses
through
four
essential
strategies:
(i)
surface
modification,
(ii)
drug
loading,
(iii)
physicochemical
parameters,
(iv)
biological
grafting.
presents
comprehensive
overview
mechanisms
system
injured
tissues
while
unveiling
adopted
orchestrate
regulation.
Furthermore,
explores
current
developmental
trends
limitations
concerning
function
drive
advancements
its
full
potential.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 4, 2024
Abstract
Diabetic
wound
healing
is
sluggish,
often
ending
in
amputations.
This
study
tested
a
novel,
two-punch
therapy
mice—Selenium
nanoparticles
(Se
NPs)
and
platelet-rich
plasma
(PRP)—to
boost
healing.
First,
mouse
model
of
diabetes
was
created.
Then,
Se
NPs
were
crafted
for
their
impressive
antioxidant
antimicrobial
powers.
PRP,
packed
with
growth
factors,
extracted
from
the
mice's
blood.
Wound
tracked
28
days
through
photos,
scoring
tools,
tissue
analysis.
alone
spurred
healing,
PRP
added
extra
fuel.
Furthermore,
when
used
combination
process
accelerated
due
to
higher
concentration
factors
PRP.
Notably,
exhibited
synergistic
effect,
significantly
enhancing
diabetic
mice.
These
findings
hold
promise
treatment
wounds
have
potential
reduce
need
lower
limb
amputations
associated
foot
ulcers.
The
innovative
using
shows
great
expediting
addressing
challenges
impaired
individuals
diabetes.
exciting
finding
suggests
this
could
change
management,
potentially
saving
limbs
improving
lives.
Biomaterials Science,
Год журнала:
2024,
Номер
12(5), С. 1079 - 1114
Опубликована: Янв. 1, 2024
Hydrogels,
formed
from
crosslinked
hydrophilic
macromolecules,
provide
a
three-dimensional
microenvironment
that
mimics
the
extracellular
matrix.
They
served
as
scaffold
materials
in
regenerative
medicine
with
an
ever-growing
demand.
However,
hydrogels
composed
of
only
organic
components
may
not
fully
meet
performance
and
functionalization
requirements
for
various
tissue
defects.
Composite
hydrogels,
containing
inorganic
components,
have
attracted
tremendous
attention
due
to
their
unique
compositions
properties.
Rigid
particles,
rods,
fibers,
Materials Today Bio,
Год журнала:
2024,
Номер
25, С. 100973 - 100973
Опубликована: Янв. 26, 2024
Extrusion-based
bioprinting
has
demonstrated
significant
potential
for
manufacturing
constructs,
particularly
3D
cell
culture.
However,
there
is
a
greatly
limited
number
of
bioink
candidates
exploited
with
extrusion-based
bioprinting,
as
they
meet
the
opposing
requirements
printability
indispensable
rheological
features
and
biochemical
functionality
desirable
microenvironment.
In
this
study,
blend
silk
fibroin
(SF)
iota-carrageenan
(CG)
was
chosen
cell-friendly
printable
material.
The
SF/CG
ink
exhibited
suitable
viscosity
shear-thinning
properties,
coupled
rapid
sol-gel
transition
CG.
By
employing
photo-crosslinking
SF,
Pr
value
close
to
1
structural
integrity
constructs
were
significantly
improved
within
matter
seconds.
printed
Young's
modulus
approximately
250
kPa,
making
them
keratinocyte
myoblast
Furthermore,
high
adhesiveness
viability
(maximum
>98%)
loaded
cells
underscored
considerable
culture
scaffold
applied
skin
muscle
tissues,
which
can
be
easily
manipulated
using
an
bioprinter.
Journal of Composites Science,
Год журнала:
2025,
Номер
9(3), С. 133 - 133
Опубликована: Март 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 506 - 531
Опубликована: Дек. 8, 2023
Intervertebral
disc
degeneration
(IVDD)
is
rising
worldwide
and
leading
to
significant
health
issues
financial
strain
for
patients.
Traditional
treatments
IVDD
can
alleviate
pain
but
do
not
reverse
disease
progression,
surgical
removal
of
the
damaged
may
be
required
advanced
disease.
The
inflammatory
microenvironment
a
key
driver
in
development
degeneration.
Suitable
anti-inflammatory
substances
are
critical
controlling
inflammation
IVDD.
Several
treatment
options,
including
glucocorticoids,
non-steroidal
drugs,
biotherapy,
being
studied
their
potential
reduce
inflammation.
However,
anti-inflammatories
often
have
short
half-life
when
applied
directly
quickly
excreted,
thus
limiting
therapeutic
effects.
Biomaterial-based
platforms
explored
as
anti-inflammation
strategies
treatment.
This
review
introduces
pathophysiology
discusses
therapeutics
components
these
unique
biomaterial
comprehensive
systems.
We
discuss
strengths,
shortcomings,
prospects
various
biomaterials
used
modulate
microenvironment,
providing
guidance
future
breakthroughs
Abstract
Traditional
patches,
such
as
sticking
plaster
or
acrylic
adhesives
used
for
over
a
hundred
years,
lack
functionality.
To
address
this
issue
of
poor
functionality,
adhesive
hydrogel
patches
have
emerged
an
efficient
bioactive
multifunctional
alternative.
Hydrogels
are
three‐dimensional,
water‐swellable,
and
polymeric
materials
closely
resembling
the
native
tissue
architecture.
The
physicochemical
properties
hydrogels
can
be
modified
easily,
allowing
them
to
suitable
various
biomedical
applications.
Moreover,
imparted
through
manipulations,
making
ideal
candidates
supplementing
replacing
traditional
plaster.
As
result,
sticky
widely
transdermal
drug
delivery
even
found
commercial
purposes.
Beyond
delivery,
also
applications
in
cardiac
therapy,
cancer
research,
biosensing,
among
other
In
mini‐review,
we
critically
discuss
challenges
fabricating
patches.
Furthermore,
introduce
some
chemical
strategies
involved
with
We
review
their
emerging
Finally,
explore
potential
future
flourishing
field
engineering
delivery.
