Nature Reviews Electrical Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
Язык: Английский
Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)
Опубликована: Сен. 12, 2022
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.
Язык: Английский
Процитировано
239
European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 258, С. 115612 - 115612
Опубликована: Июль 5, 2023
Язык: Английский
Процитировано
50
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Язык: Английский
Процитировано
4
Small, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Covalent organic frameworks (COFs), known for their exceptional in situ encapsulation and precise release capabilities, are emerging as pioneering drug delivery systems. This study introduces a hypoxia‐responsive COF designed to encapsulate the chemotherapy gambogic acid (GA) situ. Bimetallic gold‐palladium islands were grown on UiO‐66‐NH 2 (UiO) form UiO@Au‐Pd (UAPi), which encapsulated with GA through membrane formation, resulting core‐shell structure (UAPiGC). Further modification hyaluronic (HA) created @GA‐COF@HA (UAPiGCH) enhanced tumor targeting. In hypoxic microenvironment, collapses, releasing UAPi, initiating triple therapeutic response: nanozyme‐catalyzed therapy, near‐infrared II (NIR‐II) mild photothermal therapy (mild‐PTT), chemotherapy. UAPi exhibits catalase (CAT)‐like peroxidase (POD)‐like activities, generating oxygen alleviate hypoxia reactive species (ROS) destruction. acts chemotherapeutic agent inhibits heat shock protein 90 (HSP90), enhancing sensitivity. vitro vivo studies confirm UAPiGCH’s ability induce pyroptosis, stimulate dendritic cell maturation, boost T infiltration, demonstrating its potential nanoplatform. strategy integrates multiple therapies into system, offering promising applications cancer treatment.
Язык: Английский
Процитировано
2
Accounts of Materials Research, Год журнала: 2023, Номер 4(11), С. 925 - 938
Опубликована: Окт. 9, 2023
ConspectusA host–guest drug delivery system (HGDDS) refers to a complex of an artificial receptor and therapeutic agent which can dissociate at the lesion site release loaded cargo. Macrocyclic receptors are promising carriers because their superior properties, including ease preparation, precise molecular weight, well-defined structure, excellent chemical stability. The loading process is mild, simple, repeatable. formulations quantitatively load exact cavity-loading pattern quantifiable binding constant. Host–guest typically modular, may be appealing in context personalized medicine macrocyclic act as platform diverse drugs. These lead good batch reproductivity application prospects both scientific research industry. However, order make HGDDS more suitable for practical application, several demands such high affinity, universal multiple drugs, targeting, stimuli-responsiveness still need considered.The hypoxia linked diseases biological processes, cancer, acute chronic diseases, pathogenic microbe infection, other stress responses. As part our ongoing on supramolecular biomaterials based macrocycles by taking advantage recognition assembly we have developed hypoxia-responsive azocalixarenes. azocalixarenes possess deepened cavity, resulting affinities encapsulation efficiencies toward agents. azo group one most frequently employed moieties it reduced under hypoxic microenvironments. This property confers with hypoxia-triggered due remarkable decrease following reduction. fast kinetics further facilitates efficient accumulation drugs site. azocalixarene-based HGDDSs been applied preclinical studies diagnosis treatment tumor, bacterial kidney injury, rheumatoid arthritis.In this Account, outline recent efforts designing formulating We first provide brief introduction HGDDSs, features, quantitative ratiometric models. Then design principles synthesis methods, strong loading, hypoxia-response described. applications treating different followed. Finally, despite rapid development there problems that solved scientifically terms clinical translation. Therefore, propose perspectives conducted HGDDSs.
Язык: Английский
Процитировано
26
Nano TransMed, Год журнала: 2024, Номер 3, С. 100042 - 100042
Опубликована: Июль 11, 2024
Novel drug delivery systems comprise sophisticated technology merged into systems. These are created with the aim of addressing limitations conventional For instance, inefficient in tackling challenging human diseases such as cancer. thus formed materials to enhance permeation target cells. They improve patients' compliance and efficacy. include self-powered microelectromechanical Nanotechnology is a rapidly growing promising field, especially system development disease therapy. often utilise nanocarriers due their numerous advantages. One benefits ability manipulate size surface functionalisation achieve site-specific targeting. Many researchers have reported controlled targeted release profiles. Nanocarriers propelled tissues, where entrapped drugs released, prolonging therapeutic efficacy decreasing undesired side effects. Hence, these offer delivery, low toxicity, high bioavailability improved efficiency. It essential understand mechanisms toxicity order develop efficient safe This review describes utilisation novel also dwells on loading, targeting from nanocarriers. The primary concerns clinical applications potential presented. expected that this will be helpful formulation seeking solutions cancer cardiovascular diseases.
Язык: Английский
Процитировано
11
Advanced Functional Materials, Год журнала: 2024, Номер 34(48)
Опубликована: Июль 18, 2024
Abstract Two‐photon excitation (2PE) represents substantial advantages in biophotonics over traditional one‐photon (1PE), offering enhanced spatial resolution and deeper tissue penetration capabilities. Since its introduction the 1990s, two‐photon excited microscopy has spurred rapid emergence of novel 2PE‐based applications, including photodynamic therapy (PDT) targeted release biologically active agents. This review first elucidates fundamental principles 2PE before comprehensively examining evolution photosensitizers (PSs) for PDT (2P‐PDT), covering both nanomaterials small molecules, categorized based on their respective characteristics. Additionally, it explores advancements PS development integrating 2P‐PDT with other therapeutic modalities (e.g., photothermal therapy, chemotherapy, immunotherapy, gene etc.). Subsequent sections provide an overview photoactivatable compounds absorption properties controlled various agents drugs, genes, gasotransmitters), emphasizing potential anticancer applications. Last, a deep discussion deciphers prospects challenges 2P‐mediated cancer treatment, particularly concerning clinical translation.
Язык: Английский
Процитировано
10
Drug Development Research, Год журнала: 2024, Номер 85(1)
Опубликована: Янв. 27, 2024
Abstract The effectiveness of a new series thiopyrimidine and thiourea containing sulfonamides moieties was tested on HCT‐116, MCF‐7, HepG2, A549. HepG2 cell line the one that all derivatives affected most. greatest potent compounds against four HCT116, A549 lines were 8f 8g with IC 50 = 4.13, 6.64, 5.74, 6.85 µM 4.09, 4.36, 4.22, 7.25 correspondingly. Compound exhibited higher activity than sorafenib HCT116 MCF‐7 but lower Moreover, activities erlotinib demonstrated most cytotoxic 6f , 6g 8c 8d, 8e, examined normal VERO lines. Our have low toxicity cells values ranging from 32.05 to 53.15 μM. Additionally, assessed for dual VEGFR‐2 EGFR T790M inhibition effects. Compounds inhibited at value 0.88 0.90 µM, As well, could inhibit demonstrating strongest effects 0.32 0.33 sequentially. active ADMET profile evaluated in relationship as reference agents. data attained docking greatly related achieved biological testing.
Язык: Английский
Процитировано
9
ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(34), С. 38483 - 38496
Опубликована: Авг. 22, 2022
Pathogen infections impose severe challenges in clinical practice, especially for patients infected with antibiotic-resistant microbes. The thioredoxin (Trx) system Gram-positive bacteria serves as an ideal antimicrobial target novel medicine design due to the structural differences from corresponding mammals. However, a backup thiol-dependent antioxidant glutathione (GSH) limits effectiveness of drugs many Gram-negative bacteria. Herein, we synthesize thiol-targeting nanoinhibitor based on enzyme-responsive covalent organic framework (COF) coloaded silver nanoparticles (AgNPs) and ebselen (EBS) (Ag-TA-CON@EBS@PEG) exert synergistic antibacterial effects. Since azoreductase can dissociate COF, adopt this strategy achieve accurate release EBS Ag+ at infection sites. Our research identifies that functionalized shows excellent bactericidal performance vitro exhibits low toxicity normal cells. Besides, presents favorable biocompatibility, anti-inflammatory property, effective wound healing ability mice. This paper provides promising therapy enhanced properties via optimized combination targeted nanomedicines intelligent drug conveying platform.
Язык: Английский
Процитировано
31
Nanoscale, Год журнала: 2023, Номер 15(44), С. 17658 - 17697
Опубликована: Янв. 1, 2023
Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication of cancer cells via blocking DNA topoisomerase 1.
Язык: Английский
Процитировано
19