Insight into the Antioxidant Activity of 1,8-Dihydroxynaphthalene Allomelanin Nanoparticles DOI Creative Commons
Alexandra Mavridi‐Printezi, Fabio Mollica,

Rosa Lucernati

и другие.

Antioxidants, Год журнала: 2023, Номер 12(8), С. 1511 - 1511

Опубликована: Июль 28, 2023

Melanins are stable and non-toxic pigments with great potential as chemopreventive agents against oxidative stress for medical cosmetic applications. Allomelanin is a class of nitrogen-free melanin often found in fungi. The artificial allomelanin obtained by the polymerization 1,8-dihydroxynaphthalene (DHN), poly-DHN (PDHN), has been recently indicated better radical quencher than polydopamine (PDA), model dopamine (DA); however, chemical mechanisms underlying this difference unclear. Here we investigate, experimental theoretical methods, ability PDHN nanoparticles (PDHN-NP), comparison to PDA-NP, trap alkylperoxyl (ROO•) hydroperoxyl (HOO•) radicals that involved propagation peroxidation real conditions. Our results demonstrate PDHN-NP present higher antioxidant efficiency respect PDA-NP ROO• water at pH 7.4 mixed HOO• acetonitrile, showing catalytic cross-termination activity. capacity 0.8 mmol/g (ROO• quenched 1 g PDHN-NP), rate constant 3 × 105 M−1 s−1 each reactive moiety. Quantum-mechanical calculations revealed that, thanks formation H-bond network, quinones have high affinity H-atoms, thus justifying reactivity observed experimentally.

Язык: Английский

Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles DOI Open Access

Maomao Xie,

Meng Gao, Yang Yun

и другие.

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(17)

Опубликована: Янв. 31, 2023

Antimicrobial resistance (AMR) is one of the biggest threats to environment and health. AMR rapidly invalidates conventional antibiotics, antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several show AMR-independent effects without detectable new therefore suggested prevent evolution. In contrast, some are found trigger evolution AMR. Given these seemingly conflicting findings, a timely discussion two faces urgently needed. This review systematically compares killing mechanisms structure-activity relationships antibiotics nanomaterials. We then focus on nano-microbe interactions elucidate impacts molecular initiating events Finally, we provide an outlook future propose design principles for prevention

Язык: Английский

Процитировано

250
Antibacterial smart hydrogels: New hope for infectious wound management DOI Creative Commons
Zahra Aliakbar Ahovan, Zahra Esmaeili, Behnaz Sadat Eftekhari

и другие.

Materials Today Bio, Год журнала: 2022, Номер 17, С. 100499 - 100499

Опубликована: Ноя. 19, 2022

Millions of people die annually due to uncured wound infections. Healthcare systems incur high costs treat Tt is predicted become more challenging the rise multidrug-resistant conditions. During last decades, smart antibacterial hydrogels could attract attention as a promising solution, especially for skin These are termed 'smart' their response specific physical and chemical environmental stimuli. To deliver different drugs particular sites in controlled manner, various types crosslinking strategies used manufacturing process. Smart designed provide antimicrobial agents infected or built from polymers with inherent disinfectant properties. This paper aims critically review recent pre-clinical clinical advances using against infections propose next best thing future trends. For this purpose, an introduction healing disease presented intelligent responding stimuli introduced. Finally, most investigations discussed related sections. studies can pave way producing new biomaterials applications.

Язык: Английский

Процитировано

76
Designing Single‐Atom Active Sites on sp2‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy DOI Creative Commons
Baohong Sun, Xinye Wang,

Ziqiu Ye

и другие.

Advanced Science, Год журнала: 2023, Номер 10(13)

Опубликована: Фев. 27, 2023

With the threat posed by drug-resistant pathogenic bacteria, developing non-antibiotic strategies for eradicating clinically prevalent superbugs remains challenging. Ferroptosis is a newly discovered form of regulated cell death that can overcome drug resistance. Emerging evidence shows potential triggering ferroptosis-like antibacterial therapy, but direct delivery iron species inefficient and may cause detrimental effects. Herein, an effective strategy to induce bacterial nonferrous coordinating single-atom metal sites (e.g., Ir Ru) into sp

Язык: Английский

Процитировано

48
Recent advances in metal–organic frameworks for stimuli-responsive drug delivery DOI
Fei Xing, Jiawei Xu, Yuxi Zhou

и другие.

Nanoscale, Год журнала: 2024, Номер 16(9), С. 4434 - 4483

Опубликована: Янв. 1, 2024

Metal-organic frameworks have become promising stimuli-responsive agents to release the loaded therapeutic in target site achieve more precise drug delivery due their high loading, excellent biocompatibility, and stimuli-responsiveness.

Язык: Английский

Процитировано

29
Progress of stimulus responsive nanosystems for targeting treatment of bacterial infectious diseases DOI
Niuniu Yang,

Mengyuan Sun,

Huixin Wang

и другие.

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 324, С. 103078 - 103078

Опубликована: Янв. 5, 2024

Язык: Английский

Процитировано

18
Nanoplatforms Based on Covalent Organic Frameworks (COFs) for Biomedical Applications DOI
Shuang Liang, Menghao Li, Manlin Qi

и другие.

Chemistry of Materials, Год журнала: 2023, Номер 35(20), С. 8353 - 8370

Опубликована: Окт. 12, 2023

Covalent organic frameworks (COFs) make up an emerging class of crystalline porous materials mainly composed light elements in the form dynamic covalent bonds. Owing to their two- or three-dimensional network structures and ideal properties, including low density, large specific surface area, high chemical stability, good biocompatibility, COFs have shown a wide range applications optoelectronic devices, energy conversion storage, adsorption separation, sensing, catalysis, biomedicine. This review provides overview recent advances functional COF-based nanoplatforms for biological diagnosis treatment, such as enzyme protein drug delivery, photodynamic/photothermal therapy, synergistic treatment. Challenges future directions developing biomedicine related are also discussed. We envisage that this will inspire scientists, chemists, biologists, clinical doctors working fields work closely move field toward trials human healthcare.

Язык: Английский

Процитировано

35
Space-confined nanozyme with cascade reaction based on PCN-224 for synergistic bacterial infection treatment and NIR fluorescence imaging of wound bacterial infections DOI
Luogen Lai, Qiuyan Guo, Wanqing Zou

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150642 - 150642

Опубликована: Март 26, 2024

Язык: Английский

Процитировано

12
Covalent organic frameworks for antibacterial applications DOI Creative Commons

Zhuo-Qin Wang,

Xin Wang, Chang Li

и другие.

Cell Reports Physical Science, Год журнала: 2024, Номер 5(3), С. 101845 - 101845

Опубликована: Фев. 26, 2024

Covalent organic frameworks (COFs) have emerged as an important material for antimicrobial applications due to their customizable porous structures, abundant active sites, and good stability. In this perspective, we explore the topological connectivity in construction of currently developed COFs, which mainly include –B–O–, –N–H–, β-ketoenamine, azine/triazine. The advantages pristine COFs mono- synergistic antimicrobials are integrated discussed. We further summarize COF-embedded hybrid materials, such COFs/metal nanoparticles, COFs/metal-organic frameworks, COFs/carbon COFs/other demonstrate diverse design application concepts. Finally, outline challenges promising prospects COF materials biomedical industrial fields, emphasizing need these from a multidimensional perspective.

Язык: Английский

Процитировано

10
A review of recent advancement in covalent organic framework (COFs) synthesis and characterization with a focus on their applications in antibacterial activity DOI

F. Al-dolaimy,

Shelesh Krishna Saraswat, Baydaa Abed Hussein

и другие.

Micron, Год журнала: 2024, Номер 179, С. 103595 - 103595

Опубликована: Фев. 2, 2024

Язык: Английский

Процитировано

8
Sulfoxidation of pyrimidine thioate derivatives and study their biological activities DOI Creative Commons

Atif A. El‐Gharably,

Amal A. Nassar,

N. M. El-Ganzory

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 6, 2025

Abstract In a quest to innovate biologically active molecules, the benzoylation of 4,6-dimethylpyrimidine-2-thiol hydrochloride ( 1 ) with benzoyl chloride derivatives was employed produce series pyrimidine benzothioate 2–5 ). Subsequent sulfoxidation these using hydrogen peroxide and glacial acetic acid yielded diverse array sulfonyl methanone 6–9 parallel, sulfonothioates 10–12 pyrimidines 13–15 ), originating from condensation compound derivatives. The newly synthesized compounds underwent characterization via FT-IR, NMR, mass spectrometry, elemental analyses. Biological screenings unveiled interesting properties: 6 exhibited significant antimicrobial potency against S. epidermidis haemolyticus , whereas 11 showed distinct insensitivity. Excitingly, 12 showcased robust antioxidant activity by efficiently scavenging DPPH • radical, underscoring their potential in oxidative stress mitigation. Notably, 10 displayed promising anti-tumor effects, demonstrating superior efficacy MCF-7 breast cancer cell line compared . study revealed spectrum biological activities across derivatives, modifications often resulting diminished bioactivity parent These findings shed light on intricate relationship between chemical properties, offering valuable insights for future drug discovery endeavors.

Язык: Английский

Процитировано

1