Application of Nanoparticles in Cancer Treatment: A Concise Review

Nanomaterials, Год журнала: 2023, Номер 13(21), С. 2887 - 2887

Опубликована: Окт. 31, 2023

Timely diagnosis and appropriate antitumoral treatments remain of utmost importance, since cancer remains a leading cause death worldwide. Within this context, nanotechnology offers specific benefits in terms therapy by reducing its adverse effects guiding drugs to selectively target cells. In comprehensive review, we have summarized the most relevant novel outcomes range 2010-2023, covering design application nanosystems for therapy. We established general requirements nanoparticles be used drug delivery strategies their uptake tumor microenvironment vasculature, including reticuloendothelial system surface functionalization with protein corona. After brief review classes nanovectors, covered different therapies. First, advances encapsulation (such as paclitaxel fisetin) into nanoliposomes nanoemulsions are described, well relevance current clinical trials. Then, polymeric presented, namely ones comprising poly lactic-co-glycolic acid, polyethylene glycol (and PEG dilemma) dendrimers. The quantum dots bioimaging is also covered, systems zinc sulfide indium phosphide. Afterwards, reviewed gold (spheres anisotropic) plasmon-induced photothermal iron oxide nanoparticles, such magnetite maghemite, has been analyzed fields, magnetic resonance imaging, immunotherapy, hyperthermia, delivery. Lastly, recent using carbon nanomaterials, graphene oxide, nanotubes, fullerenes, dots. Finally, compared passive active targeting theranostics. This aims (nano)mark on ongoing journey towards realizing remarkable potential realm therapeutics.

Язык: Английский

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Shape dependent protein‐induced stabilization of gold nanoparticles: From a protein corona perspective

Aggregate, Год журнала: 2023, Номер 4(4)

Опубликована: Фев. 22, 2023

Abstract Gold nanoparticles (AuNPs) are promising materials for many bioapplications. However, upon contacting with biological media, AuNPs undergo changes. The interaction proteins results in the so‐called protein corona (PC) around AuNPs, leading to new bioidentity and optical properties. Understanding mechanisms of PC formation its functions can help us utilise benefits avoid drawbacks. To date, most previous works aimed understand governing focused on spherical nanoparticles, although non‐spherical designed a wide range applications biosensing. In this work, we investigated differences anisotropic (nanostars particular) from joint experimental (extinction spectroscopy, zeta potential surface‐enhanced Raman scattering [SERS]) computational methods (the finite element method molecular dynamics [MD] simulations). We discovered that does not fully cover surface leaving SERS hot‐spots at tips high curvature edges ‘available’ analyte binding (no signal after pre‐incubation protein) while providing protein‐induced stabilization (indicated by extinction spectroscopy) layer particle's core. findings confirmed our MD simulations, adsorption energy significantly decreases increased radius curvature, so (adsorption energy: 2762.334 kJ/mol) would be least preferential site compared core 11819.263 kJ/mol). These observations will development nanostructures improved sensing targeting ability.

Язык: Английский

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Biogenic Nanomaterials: Synthesis, Characterization, and Applications

Environmental science and engineering, Год журнала: 2024, Номер unknown, С. 13 - 43

Опубликована: Янв. 1, 2024

Язык: Английский

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A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications

Nanomaterials, Год журнала: 2024, Номер 14(10), С. 823 - 823

Опубликована: Май 8, 2024

Understanding both the physicochemical and biological interactions of nanoparticles is mandatory for biomedical application nanomaterials. By binding proteins, acquire new surface identities in fluids, protein corona. Various studies have revealed dynamic structure nano–bio The proteins not only imparts to fluids but also significantly influences their bioactivity, stability, targeting specificity. Interestingly, recent endeavors been undertaken harness potential corona instead evading its presence. Exploitation this ‘protein–nanoparticle alliance’ has significant change field nanomedicine. Here, we present a thorough examination latest research on corona, encompassing formation, dynamics, developments, diverse bioapplications. Furthermore, aim explore at interface, paving way innovative strategies advance addressing challenges promises controlling review provides insights into evolving landscape highlights emerging.

Язык: Английский

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Biomimetic nanoparticles with cell-membrane camouflage for rheumatoid arthritis

Matter, Год журнала: 2024, Номер 7(3), С. 794 - 825

Опубликована: Янв. 15, 2024

Язык: Английский

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Splenic response to protein corona of nanoparticles in vivo

Nano Today, Год журнала: 2025, Номер 62, С. 102676 - 102676

Опубликована: Март 1, 2025

Язык: Английский

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Harnessing Protein Corona for Biomimetic Nanomedicine Design

Biomimetics, Год журнала: 2022, Номер 7(3), С. 126 - 126

Опубликована: Сен. 6, 2022

Nanoparticles (NPs) are usually treated as multifunctional agents combining several therapeutical applications, like imaging and targeting delivery. However, clinical translation is still largely hindered by factors, the rapidly formed protein corona on surface of NPs one them. The formation complicated irreversible in biological environment, will redefine "biological identity" NPs, which alter following events therapeutic efficacy. Current understanding limited incomplete, many cases, has adverse impacts nanomedicine, for instance, losing ability, activating immune response, rapid clearance. Due to considerable role NPs' fate, harnessing achieve some effects through various methods biomimetic approaches now a promising way meet current challenges nanomedicine such poor pharmacokinetic properties, off-target effect, immunogenicity. This review first introduce summarize investigation process technologies. Second, strategies with design reviewed. Finally, we discuss future outlooks tune nanomedicine.

Язык: Английский

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Protein corona on brain targeted nanocarriers: Challenges and prospects

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 202, С. 115114 - 115114

Опубликована: Окт. 11, 2023

Язык: Английский

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Advances and Challenges of Stimuli-Responsive Nucleic Acids Delivery System in Gene Therapy

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1450 - 1450

Опубликована: Май 10, 2023

Gene therapy has emerged as a powerful tool to treat various diseases, such cardiovascular neurological ocular diseases and cancer diseases. In 2018, the FDA approved Patisiran (the siRNA therapeutic) for treating amyloidosis. Compared with traditional drugs, gene can directly correct disease-related genes at genetic level, which guarantees sustained effect. However, nucleic acids are unstable in circulation have short half-lives. They cannot pass through biological membranes due their high molecular weight massive negative charges. To facilitate delivery of acids, it is crucial develop suitable strategy. The rapid development systems brought light field, overcome multiple extracellular intracellular barriers that prevent efficient acids. Moreover, emergence stimuli-responsive made possible control release an intelligent manner precisely guide therapeutic target site. Considering unique properties systems, nanocarriers been developed. For example, taking advantage physiological variations tumor (pH, redox enzymes), biostimuli- or endogenous fabricated processes manner. addition, other external stimuli, light, magnetic fields ultrasound, also employed construct nanocarriers. Nevertheless, most preclinical stage, some critical issues remain be solved advancing clinical translation these nanocarriers, unsatisfactory transfection efficiency, safety issues, complexity manufacturing off-target effects. purpose this review elaborate principles emphasize influential advances systems. Current challenges corresponding solutions will highlighted, accelerate advance therapy.

Язык: Английский

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Nanomedicines for intranasal delivery: understanding the nano-bio interactions at the nasal mucus-mucosal barrier

Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(4), С. 553 - 572

Опубликована: Апрель 2, 2024

Intranasal administration is an effective drug delivery routes in modern pharmaceutics. However, unlike other vivo biological barriers, the nasal mucosal barrier characterized by high turnover and selective permeability, hindering diffusion of both particulate systems molecules. The fate administrated nanomedicines often significantly affected nano-biointeractions.

Язык: Английский

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