Toxicology Reports, Journal Year: 2024, Volume and Issue: 14, P. 101887 - 101887
Published: Dec. 31, 2024
Language: Английский
Aggregate, Journal Year: 2023, Volume and Issue: 4(4)
Published: Feb. 22, 2023
Abstract Gold nanoparticles (AuNPs) are promising materials for many bioapplications. However, upon contacting with biological media, AuNPs undergo changes. The interaction proteins results in the so‐called protein corona (PC) around AuNPs, leading to new bioidentity and optical properties. Understanding mechanisms of PC formation its functions can help us utilise benefits avoid drawbacks. To date, most previous works aimed understand governing focused on spherical nanoparticles, although non‐spherical designed a wide range applications biosensing. In this work, we investigated differences anisotropic (nanostars particular) from joint experimental (extinction spectroscopy, zeta potential surface‐enhanced Raman scattering [SERS]) computational methods (the finite element method molecular dynamics [MD] simulations). We discovered that does not fully cover surface leaving SERS hot‐spots at tips high curvature edges ‘available’ analyte binding (no signal after pre‐incubation protein) while providing protein‐induced stabilization (indicated by extinction spectroscopy) layer particle's core. findings confirmed our MD simulations, adsorption energy significantly decreases increased radius curvature, so (adsorption energy: 2762.334 kJ/mol) would be least preferential site compared core 11819.263 kJ/mol). These observations will development nanostructures improved sensing targeting ability.
Language: Английский
Citations
25
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: May 20, 2024
Abstract The membrane-fusion-based internalization without lysosomal entrapment is advantageous for intracellular delivery over endocytosis. However, protein corona formed on the membrane-fusogenic liposome surface converts its membrane-fusion performance to lysosome-dependent endocytosis, causing poorer efficiency in biological conditions. Herein, we develop an antifouling effective vivo. Leveraging specific lipid composition at optimized ratio, such facilitates fusion capacity even protein-rich conditions, attributed copious zwitterionic phosphorylcholine groups protein-adsorption resistance. Consequently, demonstrates robust membrane-fusion-mediated medium with up 38% fetal bovine serum, outclassing two traditional liposomes 4% and 6% concentrations. When injected into mice, can keep their membrane-fusion-transportation behaviors, thereby achieving efficient luciferase transfection enhancing gene-editing-mediated viral inhibition. This study provides a promising tool under complex physiological environments, enlightening future nanomedicine design.
Language: Английский
Citations
14
Environmental science and engineering, Journal Year: 2024, Volume and Issue: unknown, P. 13 - 43
Published: Jan. 1, 2024
Language: Английский
Citations
12
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(10), P. 823 - 823
Published: May 8, 2024
Understanding both the physicochemical and biological interactions of nanoparticles is mandatory for biomedical application nanomaterials. By binding proteins, acquire new surface identities in fluids, protein corona. Various studies have revealed dynamic structure nano–bio The proteins not only imparts to fluids but also significantly influences their bioactivity, stability, targeting specificity. Interestingly, recent endeavors been undertaken harness potential corona instead evading its presence. Exploitation this ‘protein–nanoparticle alliance’ has significant change field nanomedicine. Here, we present a thorough examination latest research on corona, encompassing formation, dynamics, developments, diverse bioapplications. Furthermore, aim explore at interface, paving way innovative strategies advance addressing challenges promises controlling review provides insights into evolving landscape highlights emerging.
Language: Английский
Citations
10
Matter, Journal Year: 2024, Volume and Issue: 7(3), P. 794 - 825
Published: Jan. 15, 2024
Language: Английский
Citations
9
Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102676 - 102676
Published: March 1, 2025
Language: Английский
Citations
1
Biomimetics, Journal Year: 2022, Volume and Issue: 7(3), P. 126 - 126
Published: Sept. 6, 2022
Nanoparticles (NPs) are usually treated as multifunctional agents combining several therapeutical applications, like imaging and targeting delivery. However, clinical translation is still largely hindered by factors, the rapidly formed protein corona on surface of NPs one them. The formation complicated irreversible in biological environment, will redefine "biological identity" NPs, which alter following events therapeutic efficacy. Current understanding limited incomplete, many cases, has adverse impacts nanomedicine, for instance, losing ability, activating immune response, rapid clearance. Due to considerable role NPs' fate, harnessing achieve some effects through various methods biomimetic approaches now a promising way meet current challenges nanomedicine such poor pharmacokinetic properties, off-target effect, immunogenicity. This review first introduce summarize investigation process technologies. Second, strategies with design reviewed. Finally, we discuss future outlooks tune nanomedicine.
Language: Английский
Citations
25
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 202, P. 115114 - 115114
Published: Oct. 11, 2023
Language: Английский
Citations
15
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1450 - 1450
Published: May 10, 2023
Gene therapy has emerged as a powerful tool to treat various diseases, such cardiovascular neurological ocular diseases and cancer diseases. In 2018, the FDA approved Patisiran (the siRNA therapeutic) for treating amyloidosis. Compared with traditional drugs, gene can directly correct disease-related genes at genetic level, which guarantees sustained effect. However, nucleic acids are unstable in circulation have short half-lives. They cannot pass through biological membranes due their high molecular weight massive negative charges. To facilitate delivery of acids, it is crucial develop suitable strategy. The rapid development systems brought light field, overcome multiple extracellular intracellular barriers that prevent efficient acids. Moreover, emergence stimuli-responsive made possible control release an intelligent manner precisely guide therapeutic target site. Considering unique properties systems, nanocarriers been developed. For example, taking advantage physiological variations tumor (pH, redox enzymes), biostimuli- or endogenous fabricated processes manner. addition, other external stimuli, light, magnetic fields ultrasound, also employed construct nanocarriers. Nevertheless, most preclinical stage, some critical issues remain be solved advancing clinical translation these nanocarriers, unsatisfactory transfection efficiency, safety issues, complexity manufacturing off-target effects. purpose this review elaborate principles emphasize influential advances systems. Current challenges corresponding solutions will highlighted, accelerate advance therapy.
Language: Английский
Citations
14
Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(4), P. 553 - 572
Published: April 2, 2024
Intranasal administration is an effective drug delivery routes in modern pharmaceutics. However, unlike other vivo biological barriers, the nasal mucosal barrier characterized by high turnover and selective permeability, hindering diffusion of both particulate systems molecules. The fate administrated nanomedicines often significantly affected nano-biointeractions.
Language: Английский
Citations
5