Journal of Controlled Release,
Год журнала:
2023,
Номер
361, С. 236 - 245
Опубликована: Авг. 8, 2023
Microneedle
Array
Patches
(MAPs)
are
an
emerging
dosage
form
that
creates
transient
micron-sized
disruptions
in
the
outermost
physical
skin
barrier,
stratum
corneum,
to
facilitate
delivery
of
active
pharmaceutical
ingredients
underlying
tissue.
Numerous
MAP
products
proposed
and
there
is
significant
clinical
potential
priority
areas
such
as
vaccination.
However,
since
their
inception
scientists
have
hypothesized
about
risk
a
clinically
MAP-induced
infection.
Safety
data
from
two
major
Phase
3
trials
involving
hundreds
participants,
who
total
received
tens
thousands
applications,
does
not
identify
any
infections.
incumbent
set
extensive
enough
make
definitive
generalizable
conclusions.
A
comprehensive
assessment
infection
therefore
advised
for
products,
this
should
be
informed
by
pre-clinical
data,
theoretical
analysis
opinions.
In
article,
group
key
stakeholders
some
product-
patient-specific
factors
may
contribute
product
provide
expert
opinions
context
guidance
regulatory
authorities.
Considerations
particularly
pertinent
include
specifications
finished
(e.g.
microbial
specification),
it's
design
features,
setting
administration,
skill
administrator,
anatomical
application
site,
target
population
context.
These
factors,
others
discussed
platform
development
assessments
stimulus
early
open
dialogue
between
developers,
authorities
other
stakeholders,
expedite
promote
safe
effective
products.
Pharmaceutics,
Год журнала:
2023,
Номер
15(1), С. 277 - 277
Опубликована: Янв. 13, 2023
Transdermal
delivery
provides
numerous
benefits
over
conventional
routes
of
administration.
However,
this
strategy
is
generally
limited
to
a
few
molecules
with
specific
physicochemical
properties
(low
molecular
weight,
high
potency,
and
moderate
lipophilicity)
due
the
barrier
function
stratum
corneum
layer.
Researchers
have
developed
several
physical
enhancement
techniques
expand
applications
transdermal
field;
among
these,
microneedle
technology
has
recently
emerged
as
promising
platform
deliver
therapeutic
agents
any
size
into
across
skin.
Typically,
hydrophilic
biomolecules
cannot
penetrate
skin
by
passive
diffusion.
Microneedle
insertion
disrupts
integrity
compromises
its
protective
function,
thus
creating
pathways
(microchannels)
for
enhanced
permeation
macromolecules.
Microneedles
not
only
improve
stability
but
also
enhance
various
biomolecules.
Academic
institutions
industrial
companies
invested
substantial
resources
in
development
systems
biopharmaceutical
delivery.
This
review
article
summarizes
most
recent
research
provide
comprehensive
discussion
about
microneedle-mediated
macromolecules,
covering
topics
from
introduction
skin,
delivery,
microneedles,
biopharmaceuticals
(current
status,
administration,
issues),
different
types,
clinical
trials,
safety
acceptability
manufacturing
regulatory
issues,
future
technology.
Journal of Controlled Release,
Год журнала:
2023,
Номер
360, С. 687 - 704
Опубликована: Июль 19, 2023
Microneedles
(MNs)
are
micron-sized
protrusions
attached
to
a
range
of
devices
that
used
in
therapeutic
delivery
and
diagnosis.
Because
MNs
can
be
self-applied,
painless,
carry
multiple
agents,
they
have
received
extensive
attention,
been
widely
investigated,
for
local
systemic
therapy.
Many
researchers
currently
working
extend
the
use
clinical
applications.
In
this
review,
we
provide
an
update
analysis
on
MN-based
trials
since
their
inception
2007.
The
classified
into
five
types
based
appearance
properties,
including:
hollow
MNs,
MN
patches,
radiofrequency
rollers,
other
MNs.
various
aspects
summarized,
such
as
types,
trial
time,
regions.
This
review
aims
present
overview
development
insights
future
research
field.
To
our
knowledge,
is
first
focused
which
showcases
latest
applications
advanced
technology
medicine.
Nano Letters,
Год журнала:
2023,
Номер
23(4), С. 1327 - 1336
Опубликована: Фев. 7, 2023
Deep
cutaneous
fungal
infection
(DCFI)
is
difficult
to
be
treated
by
the
traditional
topical
application
due
low
drug
transdermal
efficiency,
poor
fungicidal
effect,
and
easy
develop
resistance.
Here,
we
report
a
novel
biodegradable
microneedle
patch
(CuS/PAF-26
MN)
for
DCFI
treatment.
CuS/PAF-26
MN
composed
of
hyaluronic
acid
(HA)
sodium
carboxymethylcellulose
(CMC-Na),
which
can
simultaneously
deliver
copper
sulfide
nanoenzyme
(CuS
NE)
antimicrobial
peptide
(PAF-26).
CuS
NE
catalyzes
hydrogen
peroxide
produce
reactive
oxygen
species
(ROS),
PAF-26
directly
destroys
cell
membrane
fungi.
The
combination
ROS
toxicity
produced
destruction
shows
strong
antifungal
activities
without
effect
significantly
superior
that
ointment,
or
in
mouse
model.
Therefore,
promising
prospect
treating
DCFI.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Transdermal
drug
delivery
presents
a
promising
noninvasive
approach,
bypassing
first-pass
metabolism
and
gastrointestinal
degradation.
However,
the
stratum
corneum
(SC)
barrier
limits
absorption,
necessitating
development
of
effective
systems.
Microneedles,
particularly
polymer-based
ones,
offer
solution
by
penetrating
SC
while
avoiding
critical
nerves
capillaries.
These
microneedles
are
biodegradable,
nontoxic,
easily
manufacturable,
making
them
highly
attractive
platform
for
transdermal
delivery.
their
clinical
application
remains
limited
due
to
suboptimal
therapeutic
efficacy
slow
release
rates.
Recent
advancements
have
introduced
incorporation
nanodrugs,
such
as
nanoparticles
encapsulated
drugs,
into
enhance
efficiency.
Among
materials
explored,
graphene
its
derivatives,
including
oxide
(GO)
reduced
(rGO),
garnered
significant
attention.
Their
exceptional
mechanical
strength,
electrical
conductivity,
antibacterial
properties
not
only
improve
performance
but
also
rates
biocompatibility.
This
review
synthesizes
current
state
microneedle
technologies,
focusing
on
materials,
fabrication
techniques,
challenges.
It
examines
potential
graphene-based
microneedles,
comparing
traditional
in
terms
efficiency
stability.
The
highlights
key
challenges,
scalability,
biocompatibility,
complexity,
suggests
future
research
directions
address
these
issues.
quantum
dots
(GQDs)
is
identified
avenue
improving
profiles,
stability,
real-time
tracking
diffusion.
Finally,
outlines
emerging
applications,
smart
systems,
biosensing,
monitoring,
urging
further
exploration
unlock
full
graphene-enhanced
settings.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
62(10)
Опубликована: Дек. 7, 2022
Protein
and
peptide
drugs
are
predominantly
administered
by
injection
to
achieve
high
bioavailability,
but
this
greatly
compromises
patient
compliance.
Oral
transdermal
drug
delivery
with
minimal
invasiveness
adherence
represent
attractive
alternatives
administration.
However,
oral
administration
of
bioactive
proteins
must
overcome
biological
barriers,
namely
the
gastrointestinal
skin
respectively.
The
rapid
development
new
materials
technologies
promises
address
these
physiological
obstacles.
This
review
provides
an
overview
latest
advances
in
protein
delivery,
including
chemical
strategies,
synthetic
nanoparticles,
medical
microdevices,
biomimetic
systems
for
administration,
as
well
enhancers,
physical
approaches,
microneedles
delivery.
We
also
discuss
challenges
future
perspectives
field
a
focus
on
innovation
translation.
Frontiers in Drug Delivery,
Год журнала:
2022,
Номер
2
Опубликована: Сен. 5, 2022
Recent
advances
in
topical
and
transdermal
drug
delivery
systems
have
enabled
targeted
of
therapeutics
to
the
site
action
by
enhancing
permeation
across
stratum
corneum
increased
bioavailability.
Despite
various
technological
advancements,
some
dermatoses
still
limited
treatment
options
due
potential
adverse
effects
challenges
formulation
development.
To
address
limitations
posed
conventional
dermatotherapy,
nano-based
technologies
been
developed
demonstrated
a
significant
improvement
dermatotherapy.
Their
distinct
physicochemical
properties
demonstrate
their
overall
superior
therapeutic
efficacy
providing
sustained
effective
release,
as
well
improved
solubility
hydrophobic
actives
with
optimized
formulations.
These
nanocarriers
are
commonly
classified
polymeric,
lipid-based,
metallic,
vesicular
nanocarriers,
including
nanoemulsions,
nanofibers,
microneedles.
This
mini-review
aims
recent
technologies,
brief
insight
on
current
prospective
approaches
aimed
at
improving
delivery.
