Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 13, 2024
Abstract
Background
Breast
cancer
ranks
first
among
malignant
tumors,
of
which
triple-negative
breast
(TNBC)
is
characterized
by
its
highly
invasive
behavior
and
the
worst
prognosis.
Timely
diagnosis
precise
treatment
TNBC
are
substantially
challenging.
Abnormal
tumor
vessels
play
a
crucial
role
in
progression
treatment.
Nitric
oxide
(NO)
regulates
angiogenesis
maintains
vascular
homeostasis,
while
effective
NO
delivery
can
normalize
vasculature.
Accordingly,
we
have
proposed
here
microenvironment
remodeling
strategy
based
on
NO-induced
vessel
normalization
extracellular
matrix
collagen
degradation
with
multimodality
imaging-guided
nanoparticles
against
called
DNMF/PLGA.
Results
Nanoparticles
were
synthesized
using
chemotherapeutic
agent
doxorubicin
(DOX),
donor
L-arginine
(L-Arg),
ultrasmall
spinel
ferrites
(MnFe
2
O
4
),
poly
(lactic-co-glycolic
acid)
(PLGA)
shell.
Nanoparticle
distribution
was
accurately
monitored
real-time
through
enhanced
magnetic
resonance
imaging
photoacoustic
imaging.
Near-infrared
irradiation
cells
revealed
that
MnFe
catalyzes
production
large
amount
reactive
oxygen
species
(ROS)
from
H
,
resulting
cascade
catalysis
L-Arg
to
trigger
presence
ROS.
In
addition,
DOX
activates
niacinamide
adenine
dinucleotide
phosphate
oxidase
generate
supply
.
The
generated
improves
endothelial
cell
integrity
pericellular
contractility
promote
induces
activation
endogenous
metalloproteinases
(mainly
MMP-1
MMP-2)
so
as
extravascular
degradation,
thereby
providing
an
auxiliary
mechanism
for
efficient
nanoparticle
penetration.
Moreover,
effect
photothermal
served
chemo-hyperthermia
synergistic
therapy
TNBC.
Conclusion
two
therapeutic
mechanisms,
along
mechanism,
perfectly
combined
enhance
effects.
Briefly,
image-guided
provide
reliable
potential
application
fight
Graphical
ACS Nano,
Год журнала:
2024,
Номер
18(25), С. 16184 - 16198
Опубликована: Июнь 12, 2024
Drug-resistant
bacterial
infections
pose
a
serious
threat
to
human
health;
thus,
there
is
an
increasingly
growing
demand
for
nonantibiotic
strategies
overcome
drug
resistance
in
infections.
Mild
photothermal
therapy
(PTT),
as
attractive
antibacterial
strategy,
shows
great
potential
application
due
its
good
biocompatibility
and
ability
circumvent
resistance.
However,
efficiency
limited
by
the
heat
of
bacteria.
Herein,
Cu2O@MoS2,
nanocomposite,
was
constructed
situ
growth
Cu2O
nanoparticles
(NPs)
on
surface
MoS2
nanosheets,
which
provided
controllable
therapeutic
effect
intrinsic
catalytic
properties
NPs,
achieving
synergistic
eradicate
multidrug-resistant
Transcriptome
sequencing
(RNA-seq)
results
revealed
that
process
related
disrupting
membrane
transport
system,
phosphorelay
signal
transduction
oxidative
stress
response
well
system.
Animal
experiments
indicated
Cu2O@MoS2
could
effectively
treat
wounds
infected
with
methicillin-resistant
Staphylococcus
aureus.
In
addition,
satisfactory
made
promising
agent.
Overall,
our
highlight
nanocomposite
solution
combating
resistant
bacteria
without
inducing
evolution
antimicrobial
Abstract
Advanced
drug
delivery
systems
are
widely
considered
to
be
powerful
approaches
for
treating
cancer
and
many
other
diseases
because
of
their
superior
ability
improve
pharmacokinetics,
promote
lesion‐targeted
efficacy,
and/or
reduce
the
toxic
effects
diverse
therapeutics.
Owing
unique
biomimetic
structure
lipid
bilayers
surrounding
aqueous
cavities,
liposomes
have
been
found
encapsulate
various
therapeutics,
ranging
from
small
molecules
with
different
hydrophobicities
biomacromolecules.
With
advent
surface
PEGylation,
stealth
excellent
in
vivo
long‐circulating
behaviors
generated,
thus
these
extensively
explored
development
liposomal
drugs
greatly
improved
pharmacokinetic
by
functioning
as
vehicles.
Inspired
successes
clinical
practice,
recently
utilized
main
building
scaffold
or
coating
layers
nanoparticulate
formulations,
which
coined
nonclassical
nanoscale
(NDDSs)
this
review,
enable
rational
design
next‐generation
nanomedicine.
Therefore,
after
overviewing
latest
progress
conventional
liposome‐based
nanomedicine,
we
will
introduce
NDDSs
well
innovative
treatment
strategies.
We
subsequently
provide
a
critical
perspective
on
future
new
nanomedicines
based
rationally
designed
NDDSs.
The
emergence
of
multi-drug
resistant
(MDR)
pathogens
is
a
major
public
health
concern,
posing
substantial
global
economic
burden.
Photothermal
therapy
(PTT)
at
mild
temperature
presents
promising
alternative
to
traditional
antibiotics
due
its
biological
safety
and
ability
circumvent
drug
resistance.
However,
the
efficacy
PTT
limited
by
bacterial
thermotolerance.
Herein,
nanocomposite,
BP@Mn-NC,
comprising
black
phosphorus
nanosheets
manganese-based
nanozyme
(Mn-NZ)
developed,
which
possesses
both
photothermal
catalytic
properties.
Mn-NZ
imparts
glucose
oxidase-
peroxidase-like
properties
generating
reactive
oxygen
species
(ROS)
that
induce
lipid
peroxidation
malondialdehyde
accumulation
across
cell
membrane.
This
process
disrupts
unprotected
respiratory
chain
complexes
exposed
on
membrane,
leading
reduction
in
intracellular
adenosine
triphosphate
(ATP)
content.
Consequently,
mediated
BP@Mn-NC
effectively
eliminates
MDR
infections
specifically
impairing
thermotolerance
because
dependence
heat
shock
proteins
(HSPs)
ATP
molecules
for
their
proper
functioning.
study
paves
way
development
novel
strategy
eradicate
pathogens,
targets
HSPs
through
ROS-mediated
inhibition
activity.
Nanotheranostics,
Год журнала:
2024,
Номер
8(2), С. 219 - 238
Опубликована: Янв. 1, 2024
In
2020,
approximately
10
million
deaths
worldwide
were
attributed
to
cancer,
making
it
the
primary
cause
of
death
globally.Photothermal
therapy
(PTT)
is
one
novel
ways
treat
and
abolish
cancer.PTT
significantly
impacts
cancer
theranostics
compared
other
therapies
like
surgery,
chemotherapy,
radiotherapy
due
its
remarkable
binding
capability
tumor
sites
lower
invasiveness
into
normal
healthy
tissues.PTT
relies
on
photothermal
agents
(PTAs),
which
generate
heat
by
absorbing
near-infrared
(NIR)
light
destroying
cells.Several
PTT
remain
longer
in
reticuloendothelial
system
(RES)
induce
toxicity,
restricting
their
use
biomedical
field.To
overcome
this
problem,
usage
biodegradable
nano-photothermal
required.This
review
has
discussed
mechanism
action
different
types
bio-nanomaterials
used
for
PTT.We
also
focussed
combinatorial
effects
with
effect
human
health.The
role
LED
lights
mild
hypothermia
been
briefly
review.
