Bioengineering,
Год журнала:
2025,
Номер
12(4), С. 363 - 363
Опубликована: Март 31, 2025
One
area
of
study
within
machine
learning
and
artificial
intelligence
(AI)
seeks
to
create
computer
programs
with
that
can
mimic
human
focal
processes
in
order
produce
results.
This
technique
includes
data
collection,
effective
usage
system
development,
conclusion
illustration,
arrangements.
Analysis
algorithms
are
cognitive
activities
the
most
widespread
application
AI.
Artificial
studies
have
proliferated,
field
is
quickly
beginning
understand
its
potential
impact
on
medical
services
investigation.
review
delves
deeper
into
pros
cons
AI
across
healthcare
pharmaceutical
research
industries.
Research
articles
published
throughout
last
few
years
were
selected
from
PubMed,
Google
Scholar,
Science
Direct,
using
search
terms
like
‘artificial
intelligence’,
‘drug
discovery’,
‘pharmacy
research’,
‘clinical
trial’,
etc.
article
provides
a
comprehensive
overview
how
being
used
diagnose
diseases,
treat
patients
digitally,
find
new
drugs,
predict
when
outbreaks
or
pandemics
may
occur.
In
intelligence,
neural
networks
deep
some
popular
tools;
clinical
research,
Bayesian
non-parametric
approaches
hold
promise
for
better
results,
while
smartphones
processing
natural
languages
employed
recognizing
trial
monitoring.
Seasonal
flu,
Ebola,
Zika,
COVID-19,
tuberculosis,
outbreak
predictions
made
computation
intelligence.
The
academic
world
hopeful
development
will
lead
more
efficient
less
expensive
investigations
public
services.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1916 - 1916
Опубликована: Июль 10, 2023
Artificial
intelligence
(AI)
has
emerged
as
a
powerful
tool
that
harnesses
anthropomorphic
knowledge
and
provides
expedited
solutions
to
complex
challenges.
Remarkable
advancements
in
AI
technology
machine
learning
present
transformative
opportunity
the
drug
discovery,
formulation,
testing
of
pharmaceutical
dosage
forms.
By
utilizing
algorithms
analyze
extensive
biological
data,
including
genomics
proteomics,
researchers
can
identify
disease-associated
targets
predict
their
interactions
with
potential
candidates.
This
enables
more
efficient
targeted
approach
thereby
increasing
likelihood
successful
approvals.
Furthermore,
contribute
reducing
development
costs
by
optimizing
research
processes.
Machine
assist
experimental
design
pharmacokinetics
toxicity
capability
prioritization
optimization
lead
compounds,
need
for
costly
animal
testing.
Personalized
medicine
approaches
be
facilitated
through
real-world
patient
leading
effective
treatment
outcomes
improved
adherence.
comprehensive
review
explores
wide-ranging
applications
delivery
form
designs,
process
optimization,
testing,
pharmacokinetics/pharmacodynamics
(PK/PD)
studies.
an
overview
various
AI-based
utilized
technology,
highlighting
benefits
drawbacks.
Nevertheless,
continued
investment
exploration
industry
offer
exciting
prospects
enhancing
processes
care.
Vaccines,
Год журнала:
2022,
Номер
10(11), С. 1946 - 1946
Опубликована: Ноя. 17, 2022
Vaccination
is
still
the
most
cost-effective
way
to
combat
infectious
illnesses.
Conventional
vaccinations
may
have
low
immunogenicity
and,
in
situations,
only
provide
partial
protection.
A
new
class
of
nanoparticle-based
has
shown
considerable
promise
addressing
majority
shortcomings
traditional
and
subunit
vaccines.
This
due
recent
breakthroughs
chemical
biological
engineering,
which
allow
for
exact
regulation
nanoparticle
size,
shape,
functionality,
surface
characteristics,
resulting
improved
antigen
presentation
robust
immunogenicity.
blend
physicochemical,
immunological,
toxicological
experiments
can
be
used
accurately
characterize
nanovaccines.
narrative
review
will
an
overview
current
scenario
nanovaccine.
Journal of Drug Delivery Science and Technology,
Год журнала:
2023,
Номер
86, С. 104720 - 104720
Опубликована: Июнь 30, 2023
Ultraviolet
(UV)
radiation
is
the
primary
cause
of
various
skin
diseases,
necessitating
need
for
UV
protection.
Topical
sunscreens
are
most
commonly
used
method
to
achieve
this.
However,
traditional
sunscreen
formulations
have
limitations
that
hinder
their
widespread
use.
Thanks
advancements
in
nanotechnology,
new
nanotechnology-based
been
developed,
addressing
these
limitations.
The
review
explores
different
nanosystems
utilized
formulations,
including
polymeric
nanoparticles,
liposomes,
nanostructure
lipid
carriers,
solid
nanoemulsions,
hydrogels,
nanocrystals,
mesoporous
silica
particles,
niosomes,
ethosomes,
transfersomes,
transethosomes,
and
sunspheres.
These
enhance
safety
effectiveness
sunscreens,
improving
distribution,
photostability,
SPF,
UVA
protection,
water
resistance.
Combinational
which
combine
multiple
active
ingredients,
also
discussed.
They
offer
broad-spectrum
protection
against
UVB
radiation,
providing
comprehensive
sun
article
reviews
evaluation
methods
such
as
SPF
measures
level
while
indicates
defense
radiation.
Water
resistance
assesses
sunscreen's
durability
after
exposure
or
sweat.
Additionally,
addresses
safety,
regulation,
challenges
associated
with
nanosystem-based
sunscreens.
Safety
considerations
regulatory
frameworks
ensure
products'
human
health
environment.
Formulation
stability,
potential
toxicity
concerns,
lack
public
awareness
discussed
challenges.
In
summary,
promising
utilization
improves
efficacy.
Ongoing
research
efforts
vital
continued
development
safe
use
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 16, 2024
Topical
drug
delivery
is
widely
used
in
various
diseases
because
of
the
advantages
not
passing
through
gastrointestinal
tract,
avoiding
irritation
and
hepatic
first-pass
effect,
reaching
lesion
directly
to
reduce
unnecessary
adverse
reactions.
The
skin
helps
organism
defend
itself
against
a
huge
majority
external
aggressions
one
most
important
lines
defense
body.
However,
skin’s
strong
barrier
ability
also
obstacle
effectiveness
topical
medications.
Allowing
bioactive,
composition
pass
stratum
corneum
as
needed
reach
target
site
essential
need
for
exert
its
therapeutic
effect.
state
barrier,
choice
system
composition,
individualized
disease
detection
dosing
planning
influence
Nowadays,
enhancing
transdermal
absorption
topically
applied
drugs
hottest
research
area.
first
improve
all
drugs.
Excessive
enhances
accumulation
at
non-target
sites
occurrence
This
paper
introduces
strategies
from
three
perspectives:
delivery,
describes
current
status
shortcomings
research,
provides
new
directions
ideas
research.
Journal of Drug Delivery Science and Technology,
Год журнала:
2023,
Номер
85, С. 104579 - 104579
Опубликована: Май 18, 2023
Exosomes
are
multivesicular
bodies
of
which
the
plasma
membrane
fuse
to
release
caring
moiety
into
surrounding
body
fluids.
They
best
known
for
their
function
in
mediating
intercellular
connectivity
by
transferring
various
biomolecules,
such
as
proteins,
RNAs,
and
lipids,
from
one
cell
another.
These
"naturally
equipped"
nanovesicles
could
be
therapeutically
targeted
or
engineered
drug
delivery
systems.
The
use
exosomes
cancer
detection
prognosis
has
attracted
a
great
deal
interest
academics.
In
addition
chemical,
biological,
genetic
engineering
approaches,
other
current
exosomal
alteration
methodologies
hold
promise
advancement
therapeutic
medicines
cancer.
this
review,
we
highlight
theranostic
potential
cancers.
Drug Discovery Today,
Год журнала:
2024,
Номер
29(8), С. 104098 - 104098
Опубликована: Июль 10, 2024
Block
copolymer
micelles,
formed
by
the
self-assembly
of
amphiphilic
polymers,
address
formulation
challenges,
such
as
poor
drug
solubility
and
permeability.
These
micelles
offer
advantages
including
a
smaller
size,
easier
preparation,
sterilization,
superior
solubilization,
compared
with
other
nanocarriers.
Preclinical
studies
have
shown
promising
results,
advancing
them
toward
clinical
trials.
Their
mucoadhesive
properties
enhance
prolong
contact
ocular
surface,
their
small
size
allows
deeper
penetration
through
tissues,
cornea.
Additionally,
copolymeric
improve
stability
hydrophobic
drugs,
sustain
release,
allow
for
surface
modifications
to
biocompatibility.
Despite
these
benefits,
long-term
remains
challenge.
In
this
review,
we
highlight
preclinical
performance,
structural
frameworks,
preparation
techniques,
physicochemical
properties,
current
developments,
prospects
block
delivery
systems.
