Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(31)
Опубликована: Авг. 23, 2024
Abstract
Bacterial
infection‐induced
excessive
inflammation
is
a
major
obstacle
in
diabetic
wound
healing.
Nitric
oxide
(NO)
exhibits
significant
antibacterial
activity
but
extremely
deficient
diabetes.
Hence,
near‐infrared
(NIR)‐triggered
NO
release
system
constructed
through
codelivery
of
polyarginine
(PArg)
and
gold
nanorods
(Au)
an
NIR‐activatable
methylene
blue
(MB)
polypeptide‐assembled
nanovesicle
(Au/PEL‐PBA‐MB/PArg).
Upon
NIR
irradiation,
the
quenched
MB
nanovesicles
photoactivated
to
generate
more
reactive
oxygen
species
(ROS)
oxidize
PArg
on‐demand
controlled
manner.
With
specific
bacterial
capture
phenylboronic
acid
(PBA),
elevated
membrane
permeability
boosted
vulnerability
photothermal
therapy
(PTT)
Au
nanorods,
which
displayed
by
superior
mild
PTT
against
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
at
temperatures
<
49.7
°C
vitro.
Moreover,
vivo,
greatly
suppressed
burst
MRSA‐induced
inflammation,
relayed
immunomodulated
macrophage
polarization
from
M1
M2,
inflammatory
phase
successfully
transferred
repair
phase.
In
cooperation
with
angiogenesis
NO,
tissue
regeneration
accelerated
MRSA‐infected
wounds.
Therefore,
nanoplatform
has
considerable
potential
for
accelerating
healing
infected
Poor
wound
healing
is
a
refractory
process
that
places
an
enormous
medical
and
financial
burden
on
diabetic
patients.
Exosomes
have
recently
been
recognized
as
crucial
players
in
the
of
lesions.
They
excellent
stability,
homing
effects,
biocompatibility,
reduced
immunogenicity
novel
cell-free
therapies.
In
addition
to
transporting
cargos
target
cells
enhance
intercellular
communication,
exosomes
are
beneficial
nearly
every
phase
healing.
participate
modulating
inflammatory
response,
accelerating
proliferation
reepithelization,
increasing
angiogenesis,
regulating
extracellular
matrix
remodeling.
Accumulating
evidence
indicates
hydrogels
or
dressings
conjunction
with
can
prolong
duration
exosome
residency
wounds.
This
review
provides
overview
mechanisms,
delivery,
clinical
application,
engineering,
existing
challenges
use
repair.
We
also
propose
future
directions
for
biomaterials
incorporating
exosomes:
2D
3D
scaffolds,
loaded
healing-promoting
gases,
intelligent
biomaterials,
prospect
systematic
application
exosomes.
These
findings
may
might
shed
light
treatments
enlighten
some
studies
improve
quality
life
among
diabetes
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Апрель 7, 2025
Nitric
oxide
(NO)
is
essential
for
wound
healing,
promoting
angiogenesis
and
collagen
deposition.
This
study
investigates
a
novel
dual-matrix
nanocomposite
hydrogel
incorporating
S-nitrosoglutathione
(GSNO),
physiological
NO
donor,
to
enhance
cutaneous
healing.
GSNO
was
encapsulated
in
ammonio
methacrylate
copolymer
nanoparticles
embedded
an
alginate-based
matrix,
achieving
controlled
release.
GSNO-loaded
were
prepared
using
solvent
displacement
evaporation
methods,
resulting
spherical,
well-distributed
positively
charged
particles.
These
cross-linked
with
negatively
alginic
acid
form
hydrogel.
The
hydrophobic
protected
from
degradation,
while
the
hydrophilic
alginate
matrix
sustained
release
of
active
up
10
h,
haemostasis
maintaining
moist
environment.
exhibited
good
biocompatibility
human
fibroblasts
significantly
enhanced
repair
by
fibroblast
formation,
neovascularisation
deposition,
as
demonstrated
haematoxylin
eosin
staining
Masson's
trichrome
staining.
In
conclusion,
accelerated
healing
process
enhancing
offering
promising
strategy
improving
Pharmaceutics,
Год журнала:
2023,
Номер
15(12), С. 2735 - 2735
Опубликована: Дек. 6, 2023
Chronic
wounds
are
a
major
health
challenge
that
require
new
treatment
strategies.
Hydrogels
promising
drug
delivery
systems
for
chronic
wound
healing
because
of
their
biocompatibility,
hydration,
and
flexibility.
However,
conventional
hydrogels
cannot
adapt
to
the
dynamic
complex
environment,
which
involves
low
pH,
high
levels
reactive
oxygen
species,
specific
enzyme
expression.
Therefore,
smart
responsive
can
sense
respond
these
stimuli
needed.
Crucially,
modulate
release
eliminate
pathological
factors
by
changing
properties
or
structures
in
response
internal
external
stimuli,
such
as
enzymes,
light,
electricity.
These
also
be
used
trigger
antibacterial
responses,
angiogenesis,
cell
proliferation
enhance
healing.
In
this
review,
we
introduce
synthesis
principles
hydrogels,
describe
design
applications
healing,
discuss
future
development
directions.
We
hope
review
will
inspire
