Medical Gas Research,
Journal Year:
2024,
Volume and Issue:
15(1), P. 23 - 35
Published: July 25, 2024
Non-healing
wounds
are
long-term
complications
of
diabetes
mellitus
(DM)
that
increase
mortality
risk
and
amputation-related
disability
decrease
the
quality
life.
Nitric
oxide
(NO·)-based
treatments
(i.e.,
use
both
systemic
topical
NO·
donors,
precursors,
inducers)
have
received
more
attention
as
complementary
approaches
in
DM
wounds.
Here,
we
aimed
to
highlight
potential
benefits
NO·-based
on
through
a
literature
review
experimental
clinical
evidence.
Various
been
used.
In
rodents,
therapy
facilitates
wound
healing,
manifested
an
increased
healing
rate
decreased
half-closure
time.
The
effect
is
attributed
increasing
local
blood
flow,
angiogenesis
induction,
collagen
synthesis
deposition,
re-epithelization,
anti-inflammatory
anti-oxidative
properties,
potent
broad-spectrum
antibacterial
effects.
existing
lacks
human
evidence
safety
efficacy
for
Translating
favors
into
practice
needs
conducting
trials
with
well-predefined
sizes,
i.e.,
reduction
area,
hospital
length
stay.
Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 1, 2025
Poor
wound
healing
is
a
refractory
process
that
places
an
enormous
medical
and
financial
burden
on
diabetic
patients.
Exosomes
have
recently
been
recognized
as
crucial
players
in
the
of
lesions.
They
excellent
stability,
homing
effects,
biocompatibility,
reduced
immunogenicity
novel
cell-free
therapies.
In
addition
to
transporting
cargos
target
cells
enhance
intercellular
communication,
exosomes
are
beneficial
nearly
every
phase
healing.
participate
modulating
inflammatory
response,
accelerating
proliferation
reepithelization,
increasing
angiogenesis,
regulating
extracellular
matrix
remodeling.
Accumulating
evidence
indicates
hydrogels
or
dressings
conjunction
with
can
prolong
duration
exosome
residency
wounds.
This
review
provides
overview
mechanisms,
delivery,
clinical
application,
engineering,
existing
challenges
use
repair.
We
also
propose
future
directions
for
biomaterials
incorporating
exosomes:
2D
3D
scaffolds,
loaded
healing-promoting
gases,
intelligent
biomaterials,
prospect
systematic
application
exosomes.
These
findings
may
might
shed
light
treatments
enlighten
some
studies
improve
quality
life
among
diabetes
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(12), P. 2735 - 2735
Published: Dec. 6, 2023
Chronic
wounds
are
a
major
health
challenge
that
require
new
treatment
strategies.
Hydrogels
promising
drug
delivery
systems
for
chronic
wound
healing
because
of
their
biocompatibility,
hydration,
and
flexibility.
However,
conventional
hydrogels
cannot
adapt
to
the
dynamic
complex
environment,
which
involves
low
pH,
high
levels
reactive
oxygen
species,
specific
enzyme
expression.
Therefore,
smart
responsive
can
sense
respond
these
stimuli
needed.
Crucially,
modulate
release
eliminate
pathological
factors
by
changing
properties
or
structures
in
response
internal
external
stimuli,
such
as
enzymes,
light,
electricity.
These
also
be
used
trigger
antibacterial
responses,
angiogenesis,
cell
proliferation
enhance
healing.
In
this
review,
we
introduce
synthesis
principles
hydrogels,
describe
design
applications
healing,
discuss
future
development
directions.
We
hope
review
will
inspire
