Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(31)
Опубликована: Авг. 23, 2024
Abstract
Bacterial
infection‐induced
excessive
inflammation
is
a
major
obstacle
in
diabetic
wound
healing.
Nitric
oxide
(NO)
exhibits
significant
antibacterial
activity
but
extremely
deficient
diabetes.
Hence,
near‐infrared
(NIR)‐triggered
NO
release
system
constructed
through
codelivery
of
polyarginine
(PArg)
and
gold
nanorods
(Au)
an
NIR‐activatable
methylene
blue
(MB)
polypeptide‐assembled
nanovesicle
(Au/PEL‐PBA‐MB/PArg).
Upon
NIR
irradiation,
the
quenched
MB
nanovesicles
photoactivated
to
generate
more
reactive
oxygen
species
(ROS)
oxidize
PArg
on‐demand
controlled
manner.
With
specific
bacterial
capture
phenylboronic
acid
(PBA),
elevated
membrane
permeability
boosted
vulnerability
photothermal
therapy
(PTT)
Au
nanorods,
which
displayed
by
superior
mild
PTT
against
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
at
temperatures
<
49.7
°C
vitro.
Moreover,
vivo,
greatly
suppressed
burst
MRSA‐induced
inflammation,
relayed
immunomodulated
macrophage
polarization
from
M1
M2,
inflammatory
phase
successfully
transferred
repair
phase.
In
cooperation
with
angiogenesis
NO,
tissue
regeneration
accelerated
MRSA‐infected
wounds.
Therefore,
nanoplatform
has
considerable
potential
for
accelerating
healing
infected
Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(5), С. 641 - 672
Опубликована: Май 4, 2023
Introduction
Drug
treatment
is
one
of
the
main
ways
coping
with
disease
today.
For
disadvantages
drug
management,
thermosensitive
hydrogel
used
as
a
countermeasure,
which
can
realize
simple
sustained
release
drugs
and
controlled
in
complex
physiological
environments.Areas
covered
This
paper
talks
about
hydrogels
that
be
carriers.
The
common
preparation
materials,
material
forms,
thermal
response
mechanisms,
characteristics
for
applications
are
reviewed.Expert
opinion
When
loading
delivery
platforms,
desired
patterns
profiles
tailored
by
selecting
raw
forms.
properties
prepared
from
synthetic
polymers
will
more
stable
than
natural
polymers.
Integrating
multiple
mechanisms
or
different
kinds
on
same
expected
to
spatiotemporal
differential
under
temperature
stimulation.
industrial
transformation
platforms
needs
meet
some
important
conditions.
ACS Central Science,
Год журнала:
2024,
Номер
10(1), С. 184 - 198
Опубликована: Янв. 2, 2024
Nonhealing
skin
wounds
are
a
problematic
complication
associated
with
diabetes.
Therapeutic
gases
delivered
by
biomaterials
have
demonstrated
powerful
wound
healing
capabilities.
However,
the
cellular
responses
and
heterogeneity
in
regeneration
process
after
gas
therapy
remain
elusive.
Here,
we
display
benefit
of
carbon
monoxide
(CO)-releasing
hyaluronan
hydrogel
(CO@HAG)
promoting
diabetic
investigate
through
single-cell
transcriptomic
analysis.
The
presented
CO@HAG
demonstrates
microenvironment
responsive
releasing
properties
accelerates
vivo.
It
is
found
that
new
cluster
Cxcl14+
fibroblasts
progenitor
property
accumulated
CO@HAG-treated
wound.
This
yet
unreported
process.
macrophages
feature
decrease
pro-inflammatory
property,
while
their
anti-inflammatory
increases.
Moreover,
TGF-β
signal
between
(M1)
macrophage
fibroblast
attenuated
based
on
cell–cell
interaction
Our
study
provides
useful
hydrogel-mediated
method
for
insights
into
events
gas-releasing
therapy.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(31)
Опубликована: Авг. 23, 2024
Abstract
Bacterial
infection‐induced
excessive
inflammation
is
a
major
obstacle
in
diabetic
wound
healing.
Nitric
oxide
(NO)
exhibits
significant
antibacterial
activity
but
extremely
deficient
diabetes.
Hence,
near‐infrared
(NIR)‐triggered
NO
release
system
constructed
through
codelivery
of
polyarginine
(PArg)
and
gold
nanorods
(Au)
an
NIR‐activatable
methylene
blue
(MB)
polypeptide‐assembled
nanovesicle
(Au/PEL‐PBA‐MB/PArg).
Upon
NIR
irradiation,
the
quenched
MB
nanovesicles
photoactivated
to
generate
more
reactive
oxygen
species
(ROS)
oxidize
PArg
on‐demand
controlled
manner.
With
specific
bacterial
capture
phenylboronic
acid
(PBA),
elevated
membrane
permeability
boosted
vulnerability
photothermal
therapy
(PTT)
Au
nanorods,
which
displayed
by
superior
mild
PTT
against
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
at
temperatures
<
49.7
°C
vitro.
Moreover,
vivo,
greatly
suppressed
burst
MRSA‐induced
inflammation,
relayed
immunomodulated
macrophage
polarization
from
M1
M2,
inflammatory
phase
successfully
transferred
repair
phase.
In
cooperation
with
angiogenesis
NO,
tissue
regeneration
accelerated
MRSA‐infected
wounds.
Therefore,
nanoplatform
has
considerable
potential
for
accelerating
healing
infected
