The Utilization of Biopolymer Hydrogels to Encapsulate and Protect Probiotics in Foods

Process Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Liposome-Derived Nanosystems for the Treatment of Behavioral and Neurodegenerative Diseases: The Promise of Niosomes, Transfersomes, and Ethosomes for Increased Brain Drug Bioavailability

Pharmaceuticals, Год журнала: 2023, Номер 16(10), С. 1424 - 1424

Опубликована: Окт. 8, 2023

Psychiatric and neurodegenerative disorders are amongst the most prevalent debilitating diseases, but current treatments either have low success rates, greatly due to permeability of blood–brain barrier, and/or connected severe side effects. Hence, new strategies extremely important, here is where liposome-derived nanosystems come in. Niosomes, transfersomes, ethosomes nanometric vesicular structures that allow drug encapsulation, protecting them from degradation, increasing their solubility, permeability, brain targeting, bioavailability. This review highlighted great potential these for treatment Alzheimer’s disease, Parkinson’s schizophrenia, bipolar disorder, anxiety, depression. Studies regarding encapsulation synthetic natural-derived molecules in systems, intravenous, oral, transdermal, or intranasal administration, led an increased bioavailability when compared conventional pharmaceutical forms. Moreover, developed formulations proved neuroprotective, anti-inflammatory, antioxidant effects, including neurotransmitter level restoration oxidative status improvement, improved locomotor activity enhancement recognition working memories animal models. albeit being relatively technologies, niosomes, already proven increase psychoactive drugs, leading effectiveness decreased showing promise as future therapeutics.

Язык: Английский

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Oral delivery of RNAi for cancer therapy

Cancer and Metastasis Reviews, Год журнала: 2023, Номер 42(3), С. 699 - 724

Опубликована: Март 27, 2023

Язык: Английский

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Delivery of biologics: Topical administration

Biomaterials, Год журнала: 2023, Номер 302, С. 122312 - 122312

Опубликована: Сен. 4, 2023

Biologics are unaffordable to a large majority of the global population because prohibitively expensive fermentation systems, purification and requirement for cold chain storage transportation. Limitations current production delivery systems biologics were evident during recent pandemic when <2.5% vaccines produced available low-income countries ∼19 million doses discarded in Africa due lack cold-chain infrastructure. Among FDA-approved since 2015, >90% delivered using invasive methods. While oral or topical drugs highly preferred by patients their affordability convenience, only two have been approved FDA 2015. A newly launched biologic costs ∼3% average cost injectable simplified regulatory approval process elimination fermentation, purification, storage/transportation. In addition, developing new product (∼$2.5 billion) has dramatically reduced through delivery. Topical unique advantage targeted high concentration protein drugs, without getting diluted circulating blood. However, very few FDA. Therefore, this review highlights advances proteins at early advanced stages human clinical trials chewing gums, patches sprays, nucleic acid directly, combination with, nanoparticles offers future directions.

Язык: Английский

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pH Sensitive Quercetin Nanoparticles Ameliorate DSS‐Induced Colitis in Mice by Colon‐Specific Delivery

Molecular Nutrition & Food Research, Год журнала: 2023, Номер 68(2)

Опубликована: Ноя. 27, 2023

Ulcerative colitis (UC) is a classic inflammatory bowel disease (IBD) that represents serious threat to human health. As natural flavonoid with multiple biological activities, quercetin (QCT) suffers from low bioavailability through limitations in chemical stability. Here, the study investigates regulatory effects of nanoparticles (QCT NPs) on dextran sulfate sodium (DSS) induced mice.

Язык: Английский

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Pharmacokinetics and pharmacodynamics of cyclodextrin-based oral drug delivery formulations for disease therapy

Carbohydrate Polymers, Год журнала: 2024, Номер 329, С. 121763 - 121763

Опубликована: Янв. 5, 2024

Язык: Английский

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Oral targeted drug delivery to post-gastrointestinal sites

Journal of Controlled Release, Год журнала: 2024, Номер 370, С. 256 - 276

Опубликована: Май 1, 2024

Язык: Английский

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Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5359 - 5359

Опубликована: Май 14, 2024

Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral parenteral dosage forms because it increases bioavailability reduces systemic toxicity. The mucosa has a good blood supply, which ensures that molecules enter the circulation directly, avoiding metabolism during first passage through liver. At same time, number of barriers, including mucus, epithelium, enzymes, immunocompetent cells, are designed prevent entry foreign substances into body, also complicates absorption drugs. development oromucosal delivery systems based on mucoadhesive biopolymers their derivatives (especially thiolated catecholated derivatives) promising strategy for pharmaceutical safe forms. Solid, semi-solid liquid formulations have several advantageous properties, such as prolonged residence time due high mucoadhesion, unidirectional modified release capabilities, enhanced permeability. Biopolymers non-toxic, biocompatible, biodegradable may possess intrinsic bioactivity. A rational approach design requires understanding anatomy/physiology physicochemical biopharmaceutical properties molecule/biopolymer, presented in this review. This review summarizes advances (e.g., patches, buccal tablets, hydrogel systems), nanotechnology-based biopolymer nanoparticle solid lipid particles, liposomes, polyelectrolyte hybrid nanoparticles, etc.).

Язык: Английский

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Revolutionizing colon cancer therapy by site-specific 5-fluorouracil delivery with novel stimuli-responsive mucoadhesive hydrogel: Optimization via response surface methodology

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 92, С. 105358 - 105358

Опубликована: Янв. 9, 2024

Язык: Английский

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Collagen/gelatin and polysaccharide complexes enhance gastric retention and mucoadhesive properties

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 266, С. 131034 - 131034

Опубликована: Март 20, 2024

Язык: Английский

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