Applications of polydopaminic nanomaterials in mucosal drug delivery

Journal of Controlled Release, Год журнала: 2022, Номер 353, С. 842 - 849

Опубликована: Дек. 17, 2022

Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic capacity due to their abundant surface chemistry. Thus, PDA used for myriad of applications drug delivery, biosensing, imaging cancer therapy. Recent reports present new functionality as coating nanomaterial, major implications in mucosal delivery applications, particularly muco-adhesion muco-penetration. However, this application has received minimal traction the literature. In review, we functional properties highlight its key biomedical especially A detailed presentation role promising material nanoparticulate carriers intended forms core aspect review. Finally, reflection on considerations challenges utilizing along possibilities translation clinical studies expounded.

Язык: Английский

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Aspects of Nanotechnology for COVID-19 Vaccine Development and Its Delivery Applications

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 451 - 451

Опубликована: Янв. 30, 2023

Coronavirus, a causative agent of the common cold to much more complicated disease such as "severe acute respiratory syndrome (SARS-CoV-2), Middle East Respiratory Syndrome (MERS-CoV-2), and Coronavirus Disease 2019 (COVID-19)", is member coronaviridae family contains positive-sense single-stranded RNA 26-32 kilobase pairs. COVID-19 has shown very high mortality morbidity imparted significantly impacted socioeconomic status. There are many variants SARS-CoV-2 that have originated from mutation genetic material original coronavirus. This raised demand for efficient treatment/therapy manage newly emerged infections successfully. However, different types vaccines been developed administered patients but need attention because not under complete control. In this article, currently nanotechnology-based explored, inactivated virus vaccines, mRNA-based DNA-based S-protein-based virus-vectored etc. One important aspects their administration inside host body wherein nanotechnology can play crucial role. Currently, than 26 vaccine candidates in various phases clinical trials. Nanotechnology one growing fields drug discovery delivery also be used tackling ways design develop tools strategies detection, diagnosis, therapeutic development protect against COVID-19. The instruments speedy, precise, sensitive fabrication potent sanitizers, extracellular antigenic components or into human tissues, antiretroviral medicines organism management. Herein, we discuss application challenges opportunities approach.

Язык: Английский

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Development and challenges of antimicrobial peptide delivery strategies in bacterial therapy: A review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126819 - 126819

Опубликована: Сен. 15, 2023

Язык: Английский

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Understanding Mucosal Physiology and Rationale of Formulation Design for Improved Mucosal Immunity

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(8), С. 5037 - 5056

Опубликована: Май 24, 2024

The oral and nasal cavities serve as critical gateways for infectious pathogens, with microorganisms primarily gaining entry through these routes. Our first line of defense against invaders is the mucosal membrane, a protective barrier that shields body's internal systems from infection while also contributing to vital functions like air nutrient intake. One key features this its ability protect physiological system pathogens. Additionally, tolerance plays crucial role in maintaining homeostasis by regulating pH water balance within body. Recognizing importance barrier, researchers have developed various formulations enhance immune response. Mucosal vaccines, example, deliver antigens directly tissues, triggering local stimulation ultimately inducing systemic immunity. Studies shown lipid-based such liposomes virosomes can effectively elicit both responses. Furthermore, mucoadhesive polymeric particles, their prolonged delivery target sites, demonstrated an enhanced This Review delves into material selection approaches optimizing

Язык: Английский

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Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115117 - 115117

Опубликована: Окт. 26, 2023

Язык: Английский

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