Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 2011 - 2011
Опубликована: Июль 24, 2023
With
their
seemingly
limitless
capacity
for
self-improvement,
stem
cells
have
a
wide
range
of
potential
uses
in
the
medical
field.
Stem-cell-secreted
extracellular
vesicles
(EVs),
as
paracrine
components
cells,
are
natural
nanoscale
particles
that
transport
variety
biological
molecules
and
facilitate
cell-to-cell
communication
which
been
also
widely
used
targeted
drug
delivery.
These
nanocarriers
exhibit
inherent
advantages,
such
strong
cell
or
tissue
targeting
low
immunogenicity,
synthetic
lack.
However,
despite
tremendous
therapeutic
EVs,
further
clinical
application
is
still
limited
by
yield
lack
standardized
isolation
purification
protocols.
In
recent
years,
inspired
concept
biomimetics,
new
approach
to
biomimetic
delivery
has
developed
through
combining
nanotechnology
bioengineering.
This
article
reviews
derived
from
EVs
discusses
advantages
challenges
order
stimulate
future
research.
Abstract
Over
the
last
decade,
adipose‐derived
stem
cells
(ADSCs)
have
attracted
increasing
attention
in
field
of
regenerative
medicine.
ADSCs
appear
to
be
most
advantageous
cell
type
for
therapies
owing
their
easy
accessibility,
multipotency,
and
active
paracrine
activity.
This
review
highlights
current
challenges
translating
ADSC‐based
into
clinical
settings
discusses
novel
strategies
overcome
limitations
ADSCs.
To
further
establish
as
an
emerging
platform
medicine,
this
also
provides
update
on
advancements
field,
including
fat
grafting,
wound
healing,
bone
regeneration,
skeletal
muscle
repair,
tendon
reconstruction,
cartilage
cardiac
nerve
regeneration.
are
expected
more
tissue‐specific
increasingly
important
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 12, 2023
Abstract
Apoptosis,
a
form
of
programmed
cell
death,
is
essential
for
growth
and
tissue
homeostasis.
Apoptotic
bodies
(ApoBDs)
are
extracellular
vesicles
(EVs)
released
by
dying
cells
in
the
last
stage
apoptosis
were
previously
regarded
as
debris
dead
cells.
Recent
studies
unraveled
that
ApoBDs
not
but
bioactive
treasure
left
behind
with
an
important
role
intercellular
communications
related
to
human
health
various
diseases.
Defective
clearance
infected-cells-derived
possible
etiology
some
Therefore,
it
necessary
explore
function
mechanism
action
different
physiological
pathological
conditions.
advances
have
elucidated
immunomodulatory,
virus
removal,
vascular
protection,
regenerative,
disease
diagnostic
potential
ApoBDs.
Moreover,
can
be
used
drug
carriers
enhancing
stability,
cellular
uptake,
targeted
therapy
efficacy.
These
reports
from
literature
indicate
hold
promising
diagnosis,
prognosis,
treatment
diseases,
including
cancer,
systemic
inflammatory
cardiovascular
regeneration.
This
review
summarizes
recent
ApoBDs-related
research
discusses
diseases
well
challenges
prospects
ApoBDs-based
therapeutic
applications.
Graphical
Abstract
Preventing
and
treating
avascular
necrosis
at
the
distal
end
of
flaps
are
critical
to
surgery
success,
but
current
treatments
not
ideal.
A
recent
study
shows
that
apoptotic
bodies
(ABs)
generated
near
site
apoptosis
can
be
taken
up
promote
cell
proliferation.
The
reveals
ABs
derived
from
fibroblast‐like
cells
in
subcutaneous
connective
tissue
(FSCT
cells)
skin
promoted
ischaemic
flap
survival.
It
is
also
found
inhibited
death
oxidative
stress
M1‐to‐M2
polarization
macrophages.
Transcriptome
sequencing
protein
level
testing
demonstrated
survival
endothelial
macrophages
by
inhibiting
ferroptosis
via
KEAP1‐Nrf2
axis.
Furthermore,
microRNA
(miR)
data
vitro
vivo
experiments
KEAP1
delivering
miR‐339‐5p
exert
therapeutic
effects.
In
conclusion,
FSCT
cell‐derived
ferroptosis,
macrophage
transition
miR‐339‐5p/KEAP1/Nrf2
axis
These
results
provide
a
potential
strategy
administering
ABs.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2023,
Номер
42(1)
Опубликована: Март 10, 2023
Metabolic
reprogramming
is
one
of
the
hallmarks
cancer.
As
nutrients
are
scarce
in
tumor
microenvironment
(TME),
cells
adopt
multiple
metabolic
adaptations
to
meet
their
growth
requirements.
not
only
present
cells,
but
exosomal
cargos
mediates
intercellular
communication
between
and
non-tumor
TME,
inducing
remodeling
create
an
outpost
microvascular
enrichment
immune
escape.
Here,
we
highlight
composition
characteristics
meanwhile
summarize
components
corresponding
sorting
mode.
Functionally,
these
cargos-mediated
improves
"soil"
for
metastasis.
Moreover,
discuss
abnormal
metabolism
targeted
by
its
potential
antitumor
therapy.
In
conclusion,
this
review
updates
current
role
TME
enriches
future
application
scenarios
exosomes.
ACS Nano,
Год журнала:
2023,
Номер
17(9), С. 8646 - 8662
Опубликована: Апрель 26, 2023
Apoptotic
vesicles
(ApoVs)
hold
great
promise
for
inflammatory
regulation
and
tissue
repair.
However,
little
effort
has
been
dedicated
to
developing
ApoV-based
drug
delivery
platforms,
while
the
insufficient
targeting
capability
of
ApoVs
also
limits
their
clinical
applications.
This
work
presents
a
platform
architecture
that
integrates
apoptosis
induction,
loading,
functionalized
proteome
regulation,
followed
by
modification,
enabling
creation
an
apoptotic
vesicle
system
treat
ischemic
stroke.
Briefly,
α-mangostin
(α-M)
was
utilized
induce
mesenchymal
stem
cell
(MSC)
being
loaded
onto
MSC-derived
as
anti-oxidant
anti-inflammatory
agent
cerebral
ischemia/reperfusion
injury.
Matrix
metalloproteinase
activatable
cell-penetrating
peptide
(MAP),
microenvironment-responsive
peptide,
modified
on
surface
obtain
MAP-functionalized
α-M-loaded
ApoVs.
Such
engineered
targeted
injured
brain
after
systemic
injection
achieved
enhanced
neuroprotective
activity
due
synergistic
effect
α-M.
The
internal
protein
payloads
ApoVs,
upon
α-M
activation,
were
found
engaged
in
regulating
immunological
response,
angiogenesis,
proliferation,
all
which
contributed
therapeutic
effects
findings
provide
universal
framework
creating
systems
amelioration
diseases
demonstrate
potential
neural
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Май 24, 2023
Abstract
Extracellular
vesicles
(EVs),
a
cluster
of
cell-secreted
lipid
bilayer
nanoscale
particles,
universally
exist
in
body
fluids,
as
well
cell
and
tissue
culture
supernatants.
Over
the
past
years,
increasing
attention
have
been
paid
to
important
role
EVs
effective
intercellular
communicators
fibrotic
diseases.
Notably,
EV
cargos,
including
proteins,
lipids,
nucleic
acids,
metabolites,
are
reported
be
disease-specific
can
even
contribute
fibrosis
pathology.
Thus,
considered
biomarkers
for
disease
diagnosis
prognosis.
Emerging
evidence
shows
that
derived
from
stem/progenitor
cells
great
prospects
cell-free
therapy
various
preclinical
models
diseases
engineered
improve
targeting
effectiveness
their
treatment.
In
this
review,
we
will
focus
on
biological
functions
mechanisms
diseases,
potential
novel
therapeutic
strategies.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 2873 - 2890
Опубликована: Май 1, 2023
Abstract:
With
the
improvement
of
average
life
expectancy
and
increasing
incidence
obesity,
burden
liver
disease
is
increasing.
Liver
a
serious
threat
to
human
health.
Currently,
transplantation
only
effective
treatment
for
end-stage
disease.
However,
still
faces
unavoidable
difficulties.
Mesenchymal
stem
cells
(MSCs)
can
be
used
as
an
alternative
therapy
disease,
especially
cirrhosis,
failure,
complications.
MSCs
may
have
potential
tumorigenic
effects.
Exosomes
derived
from
(MSC-Exos),
important
intercellular
communication
mode
MSCs,
contain
various
proteins,
nucleic
acids,
DNA.
MSC-Exos
delivery
system
treat
diseases
through
immune
regulation,
apoptosis
inhibition,
regeneration
promotion,
drug
delivery,
other
ways.
Good
histocompatibility
material
exchangeability
make
new
diseases.
This
review
summarizes
latest
research
on
vehicles
in
different
diseases,
including
injury,
fibrosis,
hepatocellular
carcinoma
(HCC),
ischemia
reperfusion
injury.
In
addition,
we
discuss
advantages,
disadvantages,
clinical
application
prospects
MSC-Exos-based
vectors
Keywords:
exosomes,
mesenchymal
cells,
nanocarriers
