International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13611 - 13611
Опубликована: Сен. 2, 2023
Since
the
early
observations
that
nitric
oxide
(•NO)
at
high
concentrations
is
cytotoxic
to
cancer
cells
and
it
may
play
an
important
role
in
treatment
of
human
cancers,
a
significant
number
compounds
(NO-donors)
have
been
prepared
deliver
•NO
tumors.
also
sensitizes
various
clinically
active
anticancer
drugs
has
shown
induce
reversal
multi-drug
resistance
tumor
expressing
ATP-binding
cassette-transporter
proteins.
For
successful
needs
be
delivered
precisely
tumors,
its
adverse
toxicity
must
limited.
Like
other
chemotherapeutics,
precise
delivery
problem
attempts
made,
such
as
encapsulation
lipid
polymers,
overcome
this.
This
prospective
study
examines
use
strategies
for
delivering
(using
NO-donors)
cancers.
Finding
utilizing
system
step
tumors
without
reactions,
leading
clinical
outcome
patient
management.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(20)
Опубликована: Март 27, 2023
Abstract
Nanotechnology
shows
the
power
to
improve
efficacy
and
reduce
adverse
effects
of
anticancer
agents.
As
a
quinone‐containing
compound,
beta‐lapachone
(LAP)
is
widely
employed
for
targeted
therapy
under
hypoxia.
The
principal
mechanism
LAP‐mediated
cytotoxicity
believed
due
continuous
generation
reactive
oxygen
species
with
aid
NAD(P)H:
quinone
oxidoreductase
1
(NQO1).
cancer
selectivity
LAP
relies
on
difference
between
NQO1
expression
in
tumors
that
healthy
organs.
Despite
this,
clinical
translation
faces
problem
narrow
therapeutic
window
challenging
dose
regimen
design.
Herein,
multifaceted
briefly
introduced,
advance
nanocarriers
delivery
reviewed,
combinational
approaches
enhance
potency
recent
years
are
summarized.
mechanisms
by
which
nanosystems
boost
efficacy,
including
tumor
targeting,
cellular
uptake
enhancement,
controlled
cargo
release,
enhanced
Fenton
or
Fenton‐like
reaction,
multidrug
synergism,
also
presented.
problems
nanomedicines
prospective
solutions
discussed.
current
review
may
help
unlock
potential
cancer‐specific
speed
up
its
translation.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(13)
Опубликована: Дек. 21, 2023
Abstract
Almost
all
cancer
treatments
are
significantly
limited
by
the
strong
tumor
microenvironment
(TME)
fortress
formed
abnormal
vasculature,
dense
extracellular
matrix
(ECM),
multidrug
resistance
(MDR)
system,
and
immune
“cold”
environment.
In
huge
efforts
of
dismantling
TME
fortress,
nitric
oxide
(NO)‐based
nanomedicines
increasingly
occupying
a
central
position
have
already
been
identified
as
super
“strong
polygonal
warriors”
to
dismantle
for
efficient
treatment,
benefiting
from
NO's
unique
physicochemical
properties
extremely
fascinating
biological
effects.
However,
there
is
paucity
systematic
review
elaborate
on
progress
fundamental
mechanism
NO‐based
in
oncology
this
aspect.
Herein,
key
characteristics
potential
NO
reprogramming
delineated
highlighted.
The
evolution
donors
advantages
discussed
subsequently.
Moreover,
latest
solid
tumors
comprehensively
reviewed,
including
normalizing
overcoming
ECM
barrier,
reversing
MDR,
reactivating
immunosuppression
TME.
Lastly,
prospects,
limitations,
future
directions
manipulation
provide
new
insights
into
construction
more
applicable
anticancer
nanomedicines.
ACS Applied Nano Materials,
Год журнала:
2023,
Номер
7(16), С. 18590 - 18609
Опубликована: Окт. 20, 2023
The
free
radical
nitric
oxide
(NO)
is
a
signaling
molecule
that
controls
several
important
physiological
and
pathophysiological
processes
in
mammals
plants.
In
humans,
the
biological
impacts
of
NO
include,
but
are
not
limited
to,
key
roles
cardiovascular,
neurological,
immunological,
respiratory,
reproductive
systems.
plants,
modulates
plant
growth
development
with
defense
against
biotic
abiotic
stress
conditions.
However,
administration
exogenous
donors
still
faces
limitations,
mainly
due
to
their
instability
lack
bioavailability
system.
Recently,
combination
nanomaterials
has
been
extensively
explored
as
promising
strategy
tailor
spatiotemporal
release
therapeutic
amounts
NO.
Nanoscience
offers
smart
approaches
deliver
on
demand
for
particular
application.
Although
this
shown
results,
scientific
studies
less
agricultural
applications
compared
biomedical
research.
current
review
summarizes
impact
research
emphasizes
recent
progress
nanotechnology
donors.
advantages,
challenges,
drawbacks
discussed
light
inspiring
exciting
topic,
aiming
translate
these
innovations
into
clinical/practical
settings.
Clinical Cosmetic and Investigational Dermatology,
Год журнала:
2024,
Номер
Volume 17, С. 1701 - 1710
Опубликована: Июль 1, 2024
Alopecia
significantly
affects
the
appearance
and
psychology
of
patients,
pharmacological
therapies
hair
transplantation
are
main
treatments
for
alopecia,
but
both
have
limitations.
This
review
aimed
to
summarize
non-pharmacological
that
promote
growth
regeneration.
Medical Gas Research,
Год журнала:
2025,
Номер
15(2), С. 309 - 317
Опубликована: Янв. 18, 2025
Medical
gases
were
primarily
used
for
respiratory
therapy
and
anesthesia,
which
showed
promising
potential
in
the
cancer
therapy.
Several
physiological
pathological
processes
affected
by
key
gases,
such
as
oxygen,
carbon
dioxide,
nitric
oxide,
hydrogen
sulfide,
monoxide.
Oxygen
targets
shrinking
tumor
via
hyperbaric
oxygen
therapy,
once
combined
with
radiation
it
enhances
its
effect.
Nitric
oxide
has
both
anti-
pro-tumor
effects
depending
on
level;
at
high
doses,
triggers
cell
death
while
low
doses
supports
growth.
The
same
concept
is
applied
to
sulfide
promotes
growth
enhancing
mitochondrial
bioenergetics
supporting
angiogenesis
concentrations,
concentrations
induces
sparing
normal
cells.
Furthermore,
dioxide
helps
induce
apoptosis
improve
oxygenation
treatments
increasing
release
of
from
hemoglobin.
Moreover,
high-dose
monoxide
gas
demonstrated
significant
reductions
vivo
supported
nanomedicine
specialized
medicines
boost
delivery
cells
availability
peroxide.
Despite
potentials
these
several
challenges
remain.
Gas
should
be
regulated
balance
anti-tumor
sulfide.
effective
systems,
nanoparticles,
developed
targeted
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Recently,
green
gas
therapy
based
on
nitric
oxide
(NO)
has
gained
considerable
attention
in
cancer
treatment.
The
supplementation
of
exogenous
NO
and
its
controlled
release
represent
promising
strategies
for
adjuvant
tumor
therapy.
In
this
study,
we
developed
a
novel
ultrasound
(US)-triggered
generation
nanoplatform
that
integrates
therapy,
sonodynamic
photothermal
(PTT)
into
collaborative
therapeutic
modality.
An
environmentally
friendly
biomacromolecule,
polydopamine,
was
employed
to
coload
chlorin
e6
(Ce6)
donor
(BNN6),
resulting
the
nanocomposite
PDA-Ce6/BNN6
(PCB).
A
single
US
stimulus
simultaneously
activated
Ce6
produce
reactive
oxygen
species
(ROS)
promoted
BNN6
NO.
dual
effects
ultrasonic
mechanical
action
physiological
modulation
by
substantially
improved
local
vascular
function
enhanced
cell
permeability,
thereby
increasing
targeted
accumulation
PCB
within
tumors.
Reactive
nitrogen
(RNS)
derived
from
ROS
further
exacerbated
oxidative
damage
sensitivity
cells
hyperthermia.
Both
vitro
vivo
experiments
demonstrated
stimulation
NO/ROS/RNS
combined
with
PTT
effectively
inhibited
growth
proliferation.
findings
suggest
extracorporeal
can
significantly
amplify
efficacy
offer
new
insights
developing
other
aimed
at
physically
regulating
deep
