An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease

ACS Nano, Год журнала: 2023, Номер 18(1), С. 229 - 244

Опубликована: Дек. 19, 2023

Colonic epithelial damage and dysregulated immune response are crucial factors in the progression exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted drug delivery to inflamed intestinal mucosa has shown promise inducing maintaining colitis remission, while minimizing side effects. Inspired by excellent antioxidative anti-inflammatory efficacy naturally derived magnolol (Mag) gut homeostasis regulation microbiota-derived butyrate, we developed a pH/redox dual-responsive butyrate-rich polymer nanoparticle (PSBA) as an oral Mag system for combinational therapy IBD. PSBA showed high butyrate content 22% effectively encapsulated Mag. The Mag-loaded nanoparticles (PSBA@Mag) demonstrated colonic pH reduction-responsive release, ensuring efficient retention adhesion colon mice. PSBA@Mag not only normalized level reactive oxygen species effectors but also restored barrier function both ulcerative Crohn's mouse models. Importantly, promoted migration healing ability cells vitro vivo, sensitizing therapeutic animal Moreover, transcriptomics metabolism analyses revealed that mitigated inflammation suppressing production pro-inflammatory cytokines chemokines restoring lipid metabolism. Additionally, this nanomedicine modulated microbiota inhibiting pathogenic Proteus Escherichia-Shigella promoting proliferation beneficial probiotics, including Lachnoclostridium, Lachnospiraceae_NK4A136_group norank_f_Ruminococcaceae. Overall, our findings highlight potential butyrate-functionalized polymethacrylates versatile effective nanoplatforms repair combating IBD other gastrointestinal disorders.

Язык: Английский

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Nano-enabled colorectal cancer therapy

Journal of Controlled Release, Год журнала: 2023, Номер 362, С. 548 - 564

Опубликована: Сен. 9, 2023

Язык: Английский

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An olsalazine nanoneedle-embedded inulin hydrogel reshapes intestinal homeostasis in inflammatory bowel disease

Bioactive Materials, Год журнала: 2023, Номер 33, С. 71 - 84

Опубликована: Ноя. 9, 2023

Inflammatory bowel disease (IBD) is a chronic and refractory condition characterized by disrupted epithelial barrier, dysregulated immune balance, altered gut microbiota. Nano-enabled interventions for restoring homeostasis have the potential to alleviate inflammation in IBD. Herein, we developed combination of olsalazine (Olsa)-based nanoneedles microbiota-regulating inulin gel reshape intestinal relieve inflammation. The Olsa-derived exhibited reactive oxygen species scavenging ability anti-inflammatory effects lipopolysaccharide-simulated macrophages. composite (Cu2(Olsa)/Gel) displayed macroporous structure, improved bio-adhesion, enhanced colon retention after oral administration. Mechanistically, effectively downregulated pro-inflammatory cytokine levels promoted barrier repair through antioxidant therapies, resulting significant alleviation colitis three animal models Furthermore, analysis microbiota revealed that Cu2(Olsa)/Gel treatment increased diversity microflora decreased relative abundance pathogenic bacteria such as Proteobacteria. Overall, this study provides self-delivering nanodrug dietary fiber hydrogel IBD therapy, offering an efficient approach restore homeostasis.

Язык: Английский

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Mucoadhesive and thermosensitive Bletilla striata polysaccharide/chitosan hydrogel loaded nanoparticles for rectal drug delivery in ulcerative colitis

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 254, С. 127761 - 127761

Опубликована: Окт. 30, 2023

Язык: Английский

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Tannic acid-Fe3+ dual catalysis induced rapid polymerization of injectable poly(lysine) hydrogel for infected wound healing

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 249, С. 125911 - 125911

Опубликована: Июль 28, 2023

Язык: Английский

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Acid-Resistant Nano-antioxidants Based on Epigallocatechin Gallate Alleviate Acute Intestinal and Kidney Inflammation

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(35), С. 46090 - 46101

Опубликована: Авг. 22, 2024

Epigallocatechin gallate (EGCG)-based nanosystems have garnered significant attention for their ability to alleviate inflammation due excellent anti-inflammatory properties and enhanced drug delivery capabilities. However, the degradation of EGCG in strongly acidic environments poses a challenge potential administration, particularly oral formulations, where gastric resistance is essential. In this study, we develop "disintegration reorganization" strategy create acid-resistant antioxidant nanoparticles (EGA NPs) based on 5-aminosalicylic acid (5-ASA) mitigating colitis acute kidney injury. At pH, ester bond breaks down, producing two building blocks. These, together with 5-ASA formaldehyde, form oligomers through combination phenol–aldehyde condensation Mannich reaction. The resulting self-assemble into EGA NPs, which exhibit stability under both neutral pH conditions. This makes them suitable allowing withstand harsh conditions, as well intravenous injection. Importantly, these retain EGCG, effectively scavenging reactive oxygen species reducing intracellular oxidative stress. Additionally, shows carrier, efficiently loading agent curcumin (Cur) Cur@EGA NPs. vivo studies demonstrate efficacy alleviating injury following respectively. These nanoparticulate formulations superior reduction compared free Cur vivo. Overall, our findings introduce novel nanoplatform treatment inflammation.

Язык: Английский

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Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(6), С. 7686 - 7699

Опубликована: Янв. 30, 2024

The pathogenesis of ulcerative colitis (UC) is associated with the shedding gut mucus. Herein, inspired by biological functions mucus, growth factors-loaded in situ hydrogel (PHE-EK) was designed for UC treatment integrating dihydrocaffeic acid-modified poloxamer as a thermosensitive material hyaluronic acid (colitis-specific adhesive), epigallocatechin-3-gallate (antibacterial agent), and bioactive factors (KPV tripeptide epidermal factor). PHE-EK presented good properties, flowable liquid at room temperature gelled within 10 s when exposed to body temperature. mechanical strength strain 77.8%. Moreover, displayed antibacterial activity against Escherichia coli. Importantly, vitro vivo adhesive tests showed that could specifically adhere inflamed colon via electrostatic interaction. When biomimetic mucus rectally administrated rats, it effectively hindered weight loss, reduced disease index improved colonic shorting. expression pro-inflammatory cytokines (e.g., IL-1β, IL-6, TNF-α) laminae propria or epitheliums rats substantially inhibited PHE-EK. Besides, were well rearranged, tight junction proteins (Zonula-1 Claudin-5) between them greatly upregulated after treatment. Collectively, might be promising therapy UC.

Язык: Английский

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Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Biomacromolecules, Год журнала: 2023, Номер 24(5), С. 2250 - 2263

Опубликована: Апрель 17, 2023

The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy. Maintaining the level remission lesions in default treatment attitude at present. Epithelial barrier restoration considered as same important strategy colonic targeted drug delivery UC treatment. In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH enzyme dual sensitivity to reduce loss medication upper digestive tract preferentially adhere exposed epithelial cells tissues by electrostatic forces for efficiently Olsalazine an was loaded chitosan layer realized pH-responsive release. Furthermore, microspheres exhibited excellent capability suppressing harmful flora bio-adhesion effect extend duration local medicine. vivo anti-colitis study, downregulated levels pro-inflammatory factors increase tight junction protein indicated anti-inflammation olsalazine-loaded microspheres. summary, these results showed that could be powerful candidate system therapy.

Язык: Английский

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Bio-adhesive and ROS-scavenging hydrogel microspheres for targeted ulcerative colitis therapy

International Journal of Pharmaceutics, Год журнала: 2023, Номер 639, С. 122962 - 122962

Опубликована: Апрель 15, 2023

Язык: Английский

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Sustainable Revolution: AI-Driven Enhancements for Composite Polymer Processing and Optimization in Intelligent Food Packaging

Food and Bioprocess Technology, Год журнала: 2024, Номер unknown

Опубликована: Май 30, 2024

Язык: Английский

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