Curcumin-incorporated EGCG-based nano-antioxidants alleviate colon and kidney inflammation via antioxidant and anti-inflammatory therapy

Regenerative Biomaterials, Год журнала: 2024, Номер 11

Опубликована: Янв. 1, 2024

Abstract Natural remedies are gaining attention as promising approaches to alleviating inflammation, yet their full potential is often limited by challenges such poor bioavailability and suboptimal therapeutic effects. To overcome these limitations, we have developed a novel nano-antioxidant (EK) based on epigallocatechin gallate (EGCG) aimed at enhancing the oral systemic bioavailability, well anti-inflammatory efficacy, of curcumin (Cur) in conditions acute colon kidney inflammation. EK synthesized using straightforward Mannich reaction between EGCG L-lysine (K), resulting formation oligomers. These oligomers spontaneously self-assemble into nanoparticles with spherical morphology an average diameter approximately 160 nm. In vitro studies reveal that exhibit remarkable radical-scavenging capabilities effectively regulate redox processes within macrophages, key component body’s inflammatory response. By efficiently encapsulating nanoparticles, create Cur@EK, formulation demonstrates synergistic effect. Specifically, Cur@EK significantly reduces levels pro-inflammatory cytokines TNF-α IL-6 while increasing cytokine IL-10 lipopolysaccharide-stimulated highlighting its potent properties. When administered either orally or intravenously, shows superior compared free exhibits pronounced effects mouse models ulcerative colitis injury. findings suggest platform not only enhances but also amplifies impact, offering new avenue for treatment management inflammation both contexts.

Язык: Английский

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Integration of MyD88 inhibitor into mesoporous cerium oxide nanozymes-based targeted delivery platform for enhancing treatment of ulcerative colitis

Journal of Controlled Release, Год журнала: 2023, Номер 361, С. 493 - 509

Опубликована: Авг. 14, 2023

Язык: Английский

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Colon‐Targeted Release of Gel Microspheres Loaded with Antioxidative Fullerenol for Relieving Radiation‐Induced Colon Injury and Regulating Intestinal Flora

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(30)

Опубликована: Сен. 1, 2023

Radiation-induced colitis is a serious clinical problem worldwide. However, the current treatment options for this condition have limited efficacy and can cause side effects. To address issue, colon-targeted fullerenol@pectin@chitosan gel microspheres (FPCGMs) are developed, which aggregate on colon tissue long time, scavenge free radicals generated in process of radiation, regulate intestinal flora to mitigate damage colonic tissue. First, FPCGMs exhibit acid resistance release properties, reduce gastrointestinal exposure extend local drug residence time. Second, fullerenol, has superior scavenging ability chemical stability, reduces oxidative stress epithelial cells. Based this, it found that significantly inflammation tissue, mitigated tight junctions cells, relieved radiation-induced mice. Moreover, 16S ribosomal DNA (16S rDNA) sequencing results show composition optimized after utilized, indicating relative abundance probiotics increases while harmful bacteria inhibited. These findings suggest promising candidate treating colitis.

Язык: Английский

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Emerging Trends in Engineering Polymers: A Paradigm Shift in Material Engineering

Recent Progress in Materials, Год журнала: 2024, Номер 06(03), С. 1 - 37

Опубликована: Сен. 30, 2024

Emerging Trends in Engineering Polymers signify a pivotal transformation material engineering, marking departure from traditional materials towards innovative, multifunctional, and sustainable polymers. This review delineates the forefront of advancements polymer materials, including high-performance, bio-based, biodegradable, functional Highlighting their enhanced mechanical properties, thermal stability, chemical resistance showcases these materials' role driving technological progress. The exploration extends to advanced manufacturing techniques such as 3D printing, electrospinning, fabrication nanocomposites, underscoring impact on customizing product properties scaling production. Central this discourse is sustainability environmental stewardship sector, addressing recycling methodologies, circular economy, regulatory frameworks guiding practices. juxtaposes emerging processes, illuminating path toward more cycles. Furthermore, it ventures into applications across diverse sectors energy, electronics, healthcare, automotive, aerospace, elucidating transformative potential engineering polymers domains. Challenges spanning technical, economic, environmental, landscapes are critically examined, setting stage for future directions research development. culminates forward-looking perspective, advocating interdisciplinary collaboration science innovation navigate modern challenges' complexities. Through comprehensive analysis, articulates narrative evolution opportunity within polymers, poised redefine decades come.

Язык: Английский

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Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 294, С. 139114 - 139114

Опубликована: Янв. 2, 2025

Язык: Английский

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