ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(5), С. 3469 - 3482
Опубликована: Апрель 23, 2024
Bacterial
invasion
hinders
the
healing
process
of
wound,
leading
to
formation
chronic
infected
wound;
meanwhile,
misuse
antibiotics
has
resulted
in
emergence
numerous
drug-resistant
bacteria.
The
application
conventional
antimicrobial
methods
and
wound
treatment
techniques
is
not
appropriate
for
dressings.
In
this
paper,
quaternized
poly(vinyl
alcohol)
(QPVA)
pomegranate-like
copper
uniformly
doped
polydopamine
nanoparticles
(PDA@Cu)
were
introduced
into
a
gelatin-oxidized
carboxymethyl
cellulose
system
form
multicomponent
synergistic
antibacterial
hydrogel
(GOQ
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(25), С. 32104 - 32117
Опубликована: Июнь 12, 2024
The
repair
of
infected
wounds
is
a
complex
physiopathologic
process.
Current
studies
on
wound
treatment
have
predominantly
focused
infection
treatment,
while
the
factors
related
to
delayed
healing
caused
by
vascular
damage
and
immune
imbalance
are
commonly
overlooked.
In
this
study,
an
extracellular
matrix
(ECM)-like
dynamic
multifunctional
hyaluronic
acid
(HA)
hydrogel
with
antimicrobial,
immunomodulatory,
angiogenic
capabilities
was
designed
as
dressing
for
skin
wounds.
network
in
based
reversible
metal–ligand
coordination
formed
between
sulfhydryl
groups
bioactive
metal
ions.
our
design,
antibacterial
silver
immunomodulatory
zinc
ions
were
employed
coordinate
sulfhydrylated
HA
vasculogenic
peptide.
addition
desired
bioactivities
wounds,
could
also
exhibit
self-healing
injectable
abilities.
Animal
experiments
models
indicated
that
dressings
enabled
minimally
invasive
injection
seamless
covering
then
facilitated
efficient
bacterial
killing,
continuous
inflammation
inhibition,
improved
blood
vessel
formation.
conclusion,
ion-coordinated
hydrogels
wound-infection-desired
ECM-like
structures
represent
class
tissue
bionic
chronic
Hemostatic
powder,
which
can
absorb
large
amounts
of
water
and
tends
to
produce
repeated
hydration
with
tissue,
has
been
clinically
proven
as
an
ideal
engineering
material
for
treating
wounds
tissues.
We
herein
designed
a
polypeptide-based
hemostatic
powder.
A
water-soluble
polypeptide,
γ-polyglutamic
acid
(γ-PGA),
was
mixed
the
polyethyleneimine
(PEI),
N-hydroxysuccinimide,
1-(3-dimethylaminopropyl)-3-ethylcarbodiimide.
The
solution
these
polymers
lyophilized
harvest
γ-PGA/PEI
powder
(PP
powder).
When
deposited
on
bleeding
wound,
PP
quickly
amount
blood
interstitial
fluid,
concentrate
coagulation
factors,
coagulate
cells,
eventually
form
stable
mechanical
hydrogel.
wound
time
group
1.8
±
0.4
min,
significantly
lower
than
that
commercial
chitosan
(2.8
min).
endowed
antioxidant
capacity
by
introducing
protocatechuic
aldehyde,
effectively
inhibit
inflammation
promote
healing.
Therefore,
via
preparation
through
facile
lyophilization
method,
is
expected
find
wide
application
prospect
qualified
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(5), С. 3469 - 3482
Опубликована: Апрель 23, 2024
Bacterial
invasion
hinders
the
healing
process
of
wound,
leading
to
formation
chronic
infected
wound;
meanwhile,
misuse
antibiotics
has
resulted
in
emergence
numerous
drug-resistant
bacteria.
The
application
conventional
antimicrobial
methods
and
wound
treatment
techniques
is
not
appropriate
for
dressings.
In
this
paper,
quaternized
poly(vinyl
alcohol)
(QPVA)
pomegranate-like
copper
uniformly
doped
polydopamine
nanoparticles
(PDA@Cu)
were
introduced
into
a
gelatin-oxidized
carboxymethyl
cellulose
system
form
multicomponent
synergistic
antibacterial
hydrogel
(GOQ
