Nanotechnology Reviews,
Год журнала:
2024,
Номер
13(1)
Опубликована: Янв. 1, 2024
Abstract
Currently,
liver
cancer
is
the
leading
cause
of
cancer-related
death
worldwide,
with
a
low
5-year
survival
rate,
which
will
further
decrease
if
advanced
metastasis
present.
Hepatocellular
carcinoma
(HCC)
main
type.
However,
due
to
lack
specific
symptoms
in
early
stages,
it
more
difficult
detect
HCC,
and
many
patients
would
have
already
been
diagnosed
cancer.
At
this
point,
treatment
methods
available
at
diagnosis
become
ineffective.
Therefore,
there
an
urgent
need
for
effective
HCC.
In
recent
years,
nanoparticles
used
HCC
their
good
biocompatibility
other
advantages.
Different
types
are
modified
play
role
such
as
regulating
tumor
microenvironment,
enhancing
activity
drug
targeting
killing
cells,
reducing
systemic
side
effects.
It
can
significantly
improve
therapeutic
effect
bring
hope
review,
several
common
introduced,
characteristics
described
detail.
addition,
construction
highly
efficient
delivery
system
by
combination
nanoparticle-targeted
therapy,
chemotherapy,
radiotherapy
reviewed.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Current Pharmaceutical Design,
Год журнала:
2024,
Номер
31(4), С. 244 - 260
Опубликована: Апрель 30, 2024
In
recent
years,
advancements
in
chemistry
have
allowed
the
tailoring
of
materials
at
nanoscopic
level
as
needed.
There
are
mainly
four
main
types
nanomaterials
used
drug
carriers:metal-based
nanomaterials,
organic
inorganic
and
polymer
nanomaterials.
The
a
carrier
showed
advantages
for
decreased
side
effects
with
higher
therapeutic
index.
stability
compounds
increased
by
encapsulation
within
nano-drug
carriers,
leading
to
systemic
toxicity.
Nano-drug
carriers
also
controlled
release
system-made
solubility
characteristics
nanoparticles
surface
coating
surfactants.
review
focuses
on
different
nanoparticle
synthesis
process,
techniques
purposes,
applications
prospects
biomedical
applications.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 21, 2025
Tumor
immunotherapy
aims
to
harness
the
immune
system
identify
and
eliminate
cancer
cells.
However,
its
full
potential
is
hindered
by
immunosuppressive
nature
of
tumors.
Radiotherapy
remains
a
key
treatment
modality
for
local
tumor
control
immunomodulation
within
microenvironment.
Yet,
efficacy
radiotherapy
often
limited
radiosensitivity,
traditional
radiosensitizers
have
shown
effectiveness
in
hepatocellular
carcinoma
(HCC).
To
address
these
challenges,
we
developed
novel
multifunctional
nanoparticle
system,
ZIF-8@MnCO@DOX
(ZMD),
designed
enhance
drug
delivery
tissues.
In
microenvironment,
Zn²⁺
Mn²⁺
ions
released
from
ZMD
participate
Fenton-like
reaction,
generating
reactive
oxygen
species
(ROS)
that
promote
cell
death
improve
radiosensitivity.
Additionally,
release
doxorubicin
(DOX)-an
anthracycline
chemotherapeutic
agent-induces
DNA
damage
apoptosis
The
combined
action
metal
double-stranded
(dsDNA)
damaged
cells
synergistically
activates
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway,
thereby
initiating
robust
anti-tumor
response.
Both
vitro
vivo
experiments
demonstrated
effectively
cGAS-STING
promotes
responses,
exerts
potent
tumor-killing
effect
combination
with
radiotherapy,
leading
regression
both
primary
tumors
distant
metastases.
Our
work
provides
straightforward,
safe,
effective
strategy
combining
treat
advanced
cancer.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 14, 2024
Abstract
Due
to
the
limitations
of
single-model
tumor
therapeutic
strategies,
multimodal
combination
therapy
have
become
a
more
favorable
option
enhance
efficacy
by
compensating
for
its
deficiencies.
However,
in
nanomaterial-based
therapeutics
tumors,
exploiting
synergistic
interactions
and
cascade
relationships
materials
achieve
effective
treatments
is
still
great
challenge.
Based
on
this,
we
constructed
nanoplatform
with
“triple-linkage”
effect
cleverly
integrating
polydopamine
(PDA),
silver
nanoparticles
(AgNPs),
glucose
oxidase
(GOx)
realize
enhanced
photothermal
(PTT)
activatable
metal
ion
(MIT)
hepatocellular
carcinoma
(HCC)
treatment.
First,
non-radiative
conversion
PDA
under
light
conditions
was
AgNPs,
which
directly
efficiency
PDA.
In
addition,
GOx
reduced
synthesis
cellular
heat
shock
proteins
interfering
energy
metabolism,
thereby
enhancing
sensitivity
PTT.
On
other
hand,
H
2
O
,
by-product
GOx-catalyzed
glucose,
could
be
used
as
an
activation
source
activate
non-toxic
AgNPs
release
cytotoxic
Ag
+
achieving
-mediated
MIT.
conclusion,
this
nanosystem
achieved
efficient
PTT
MIT
HCC
among
PDA,
GOx,
providing
novel
idea
design
systems
regulation.
Graphical
abstract
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 175 - 175
Опубликована: Янв. 26, 2024
Cancer
is
defined
as
the
uncontrolled
proliferation
of
heterogeneous
cell
cultures
in
body
that
develop
abnormalities
and
mutations,
leading
to
their
resistance
many
forms
treatment.
Left
untreated,
these
abnormal
growths
can
lead
detrimental
even
fatal
complications
for
patients.
Radiation
therapy
involved
around
50%
cancer
treatment
workflows;
however,
it
presents
significant
recurrence
rates
normal
tissue
toxicity,
given
inevitable
deposition
dose
surrounding
healthy
tissue.
Chemotherapy
another
modality
with
excessive
toxicity
significantly
affects
patients’
quality
life.
To
improve
therapeutic
efficacy
radiotherapy
chemotherapy,
multiple
conjunctive
modalities
have
been
proposed,
which
include
targeting
components
tumour
microenvironment
inhibiting
spread
anti-therapeutic
pathways,
increasing
oxygen
content
within
revert
hypoxic
nature
malignancy,
improving
local
metal
nanoparticles,
restriction
cycle
radiosensitive
phases.
The
largely
responsible
nanoparticle
capture
itself
various
therapy.
In
this
review,
we
discuss
current
literature
administration
molecular
therapeutics,
pharmacokinetics,
contrasting
mechanisms
action.
review
aims
demonstrate
advancements
field
conjugated
nanomaterials
radiotherapeutics
targeting,
inhibiting,
or
bypassing
promote
further
research
outcomes
rates.
