Current perspectives on mesenchymal stromal cell therapy for graft versus host disease

Cellular and Molecular Immunology, Год журнала: 2023, Номер 20(6), С. 613 - 625

Опубликована: Май 10, 2023

Abstract Graft versus host disease (GvHD) is the clinical condition in which bone marrow-derived mesenchymal stromal cells (MSCs) have been most frequently studied. In this review, we summarize experience from trials that paved way to translation. While MSC-based therapy has shown an exceptional safety profile, identifying potency assays and biomarkers reliably predict capacity of a specific MSC batch alleviate GvHD difficult. As diagnosis staging are based solely on criteria, individual patients recruited same trial may vastly different underlying biology, obscuring outcomes making it difficult determine benefit MSCs subgroups patients. An accumulating body evidence indicates importance considering not only cell product but also patient-specific and/or immune characteristics determining responsiveness. A mode action where intravascular destruction followed by monocyte-efferocytosis-mediated skewing repertoire permissive inflammatory environment would both explain why engraftment irrelevant for efficacy stress biologic differences between responding nonresponding We recommend combined analysis activity identify with who likely therapy.

Язык: Английский

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Therapeutic and immunomodulatory potentials of mesenchymal stromal/stem cells and immune checkpoints related molecules

Biomarker Research, Год журнала: 2024, Номер 12(1)

Опубликована: Март 21, 2024

Mesenchymal stromal/stem cells (MSCs) are used in many studies due to their therapeutic potential, including differentiative ability and immunomodulatory properties. These perform functions by using various mechanisms, such as the production of anti-inflammatory cytokines, growth factors, direct cell-to-cell contact, extracellular vesicles (EVs) production, mitochondrial transfer. However, mechanisms related immune checkpoints (ICPs) effect on MSCs less discussed. The main function ICPs is prevent initiation unwanted responses regulate system maintain homeostasis these responses. produced types regulatory cells, defects expression may be associated with excessive that can ultimately lead autoimmunity. Also, expressing different ligands (ICPLs), tumor formation durability responses, which leads tumors' escape. ICPLs affect cell both through secretion into microenvironment or interaction. Pre-treatment inflammatory conditions an increase potential. In addition environments have cytokines MSCs, they ICPLs. this review, we discuss expressed

Язык: Английский

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Targeting different phenotypes of macrophages: A potential strategy for natural products to treat inflammatory bone and joint diseases

Phytomedicine, Год журнала: 2023, Номер 118, С. 154952 - 154952

Опубликована: Июль 12, 2023

Язык: Английский

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Engineered stem cell-based strategy: A new paradigm of next-generation stem cell product in regenerative medicine

Journal of Controlled Release, Год журнала: 2023, Номер 365, С. 981 - 1003

Опубликована: Дек. 21, 2023

Язык: Английский

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Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression

Cytokine & Growth Factor Reviews, Год журнала: 2024, Номер 76, С. 30 - 47

Опубликована: Фев. 2, 2024

Язык: Английский

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Transfer and fates of damaged mitochondria: role in health and disease

FEBS Journal, Год журнала: 2024, Номер unknown

Опубликована: Март 28, 2024

Intercellular communication is pivotal in mediating the transfer of mitochondria from donor to recipient cells. This process orchestrates various biological functions, including tissue repair, cell proliferation, differentiation and cancer invasion. Typically, dysfunctional depolarized are eliminated through intracellular or extracellular pathways. Nevertheless, increasing evidence suggests that intercellular damaged associated with pathogenesis diverse diseases. review investigates prevalent triggers mitochondrial damage underlying mechanisms transfer, elucidates role directional both physiological pathological contexts. Additionally, we propose potential previously unknown explore their prospective roles disease prevention therapy.

Язык: Английский

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Horizontal mitochondrial transfer as a novel bioenergetic tool for mesenchymal stromal/stem cells: molecular mechanisms and therapeutic potential in a variety of diseases

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Май 24, 2024

Abstract Intercellular mitochondrial transfer (MT) is a newly discovered form of cell-to-cell signalling involving the active incorporation healthy mitochondria into stressed/injured recipient cells, contributing to restoration bioenergetic profile and cell viability, reduction inflammatory processes normalisation calcium dynamics. Recent evidence has shown that MT can occur through multiple cellular structures mechanisms: tunneling nanotubes (TNTs), via gap junctions (GJs), mediated by extracellular vesicles (EVs) other mechanisms (cell fusion, extrusion migrasome-mediated mitocytosis) in different contexts, such as under physiological (tissue homeostasis stemness maintenance) pathological conditions (hypoxia, inflammation cancer). As Mesenchimal Stromal/ Stem Cells (MSC)-mediated emerged critical regulatory restorative mechanism for tissue regeneration damage repair recent years, its potential stem therapy received increasing attention. In particular, therapeutic role MSCs been reported several articles, suggesting enhance after injury membrane vesicle release. For these reasons, this review, we will discuss MSCs-mediated effects on diseases neuronal, ischaemic, vascular pulmonary diseases. Therefore, understanding molecular demonstrating efficacy could be an important milestone lays foundation future clinical trials.

Язык: Английский

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Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Май 23, 2023

Pancreatic cancer (PC) is one of the most dangerous diseases that threaten human life, and investigating details affecting its progression or regression particularly important. Exosomes are derivatives produced from different cells, including tumor cells other such as Tregs, M2 macrophages, MDSCs, can help growth. These exosomes perform their actions by in microenvironment, pancreatic stellate (PSCs) produce extracellular matrix (ECM) components immune responsible for killing cells. It has also been shown cell (PCC)-derived at stages carry molecules. Checking presence these molecules blood body fluids us early stage diagnosis monitoring PC. However, system cell-derived (IEXs) mesenchymal stem (MSC)-derived contribute to PC treatment. Immune part mechanisms involved surveillance cell-killing phenomenon. be modified a way antitumor properties enhanced. One methods drug loading exosomes, which significantly increase effectiveness chemotherapy drugs. In general, form complex intercellular communication network plays role developing, progressing, diagnosing, monitoring, treating cancer.

Язык: Английский

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Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration

Nature Reviews Urology, Год журнала: 2023, Номер 20(12), С. 739 - 761

Опубликована: Июль 6, 2023

Язык: Английский

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Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15788 - 15788

Опубликована: Окт. 31, 2023

Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs) have been the focus intense preclinical research and clinical implementation for decades. MSCs multilineage differentiation capacity, support hematopoiesis, secrete pro-regenerative factors exert immunoregulatory functions promoting homeostasis resolution injury/inflammation. The main include modulation immune cells (macrophages, neutrophils, lymphocytes), secretion antimicrobial peptides, transfer mitochondria (Mt) injured cells. These actions can be enhanced by priming (i.e., licensing) prior exposure deleterious microenvironments. Preclinical evidence suggests that therapeutic a variety pathological states, including cardiac, respiratory, hepatic, renal, neurological diseases. One key emerging is improvement mitochondrial tissues enhancing quality control (MQC). Recent advances understanding cellular MQC, biogenesis, mitophagy, fission, fusion, helped uncover how enhance these processes. Specifically, suggested regulate peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC1α)-dependent Parkin-dependent Mitofusins (Mfn1/2) or Dynamin Related Protein-1 (Drp1)-mediated fission/fusion. In addition, previous studies also verified from through tunneling nanotubes via microvesicular transport. Combined, improve functions, thereby contributing injury inflammation. Thus, uncovering affect MQC opens new avenues organ injury, transplantation MSC-derived might represent attractive approach.

Язык: Английский

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