Advances in clinical neurorestorative treatments of Parkinson’s disease

Journal of Neurorestoratology, Год журнала: 2025, Номер unknown, С. 100204 - 100204

Опубликована: Март 1, 2025

Язык: Английский

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Idiopathic pulmonary fibrosis microenvironment: Novel mechanisms and research directions

International Immunopharmacology, Год журнала: 2025, Номер 155, С. 114653 - 114653

Опубликована: Апрель 14, 2025

Язык: Английский

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Cancer-associated mesenchymal stem/stromal cells: role in progression and potential targets for therapeutic approaches

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 3, 2023

Malignancies contain a relatively small number of Mesenchymal stem/stromal cells (MSCs), constituting crucial tumor microenvironment (TME) component. These comprise approximately 0.01–5% the total TME cell population. MSC differentiation potential and their interaction with environment enable these to affect cells’ growth, immune evasion, metastasis, drug resistance, angiogenesis. This type MSC, known as cancer-associated mesenchymal (CA-MSCs (interacts tumor/non-tumor in affects function by producing cytokines, chemokines, various growth factors facilitate migration, survival, proliferation, progression. Considering that effect different on each other is multi-faceted relationship, it essential discover role relationships for targeting therapy. Due immunomodulatory tissue repair characteristic MSCs, can help from aspects. CA-MSCs indirectly suppress antitumor response through several mechanisms, including decreasing dendritic (DCs) antigen presentation potential, disrupting natural killer (NK) differentiation, inducing immunoinhibitory subsets like tumor-associated macrophages (TAMs) Treg cells, checkpoint expression reduce effector T responses. Therefore, if be targeted treatment so population decreases, we hope improvement conditions. Also, studies show vital aspects tumor, angiogenesis, invasion metastasis. In this review article, will discuss detail some mechanisms which innate adaptive systems related

Язык: Английский

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Combinational administration of mesenchymal stem cell-derived exosomes and metformin reduces inflammatory responses in an in vitro model of insulin resistance in HepG2 cells

Heliyon, Год журнала: 2023, Номер 9(5), С. e15489 - e15489

Опубликована: Апрель 14, 2023

Diabetes is a highly common metabolic disorder in advanced societies. One of the causes diabetes insulin resistance, which associated with loss sensitivity to insulin-sensitive cells. Insulin resistance develops body person prone many years before development. complications such as hyperglycemia, hyperlipidemia, and compensatory hyperinsulinemia liver inflammation, which, if left untreated, can lead cirrhosis, fibrosis, even cancer. Metformin first line treatment for patients diabetes, lowers blood sugar increases by inhibiting gluconeogenesis The use metformin has side effects, including metallic taste mouth, vomiting, nausea, diarrhea, upset stomach. For this reason, other treatments, along metformin, are being developed. Considering anti-inflammatory role mesenchymal stem cells (MSCs) derived exosomes, their seems help improve tissue function prevent damage caused inflammation. This study investigated effect Wharton's jelly MSCs exosomes combination HepG2 model induced high glucose. showed that an agent could increase therapeutic efficacy without needing change doses decreasing inflammatory cytokines production, IL-1, IL-6, TNF-α apoptosis

Язык: Английский

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Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells

Mitochondrion, Год журнала: 2024, Номер 76, С. 101856 - 101856

Опубликована: Фев. 24, 2024

Язык: Английский

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