Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
45(17)
Опубликована: Май 30, 2024
Core-shell
tecto
dendrimers
(CSTDs)
with
excellent
physicochemical
properties
and
good
tumor
penetration
gene
transfection
efficiency
have
been
demonstrated
to
the
potential
replace
high-generation
in
biomedical
applications.
However,
their
characterization
related
biological
of
CSTDs
for
enhanced
delivery
still
lack
in-depth
investigation.
Herein,
three
types
dual-responsive
are
designed
thorough
investigation
efficiency.
Three
prepared
through
phenylborate
ester
bonds
phenylboronic
acid
(PBA)-decorated
generation
5
(G5)
poly(amidoamine)
(PAMAM)
as
cores
monose
(galactose,
glucose,
or
mannose)-conjugated
G3
PAMAM
shells
thoroughly
characterized
via
NMR
other
techniques.
It
is
shown
that
produced
display
strong
correlation
signals
between
PBA
protons,
similar
hydrodynamic
diameters,
dual
reactive
oxygen
species-
pH-responsivenesses.
The
proven
structure-dependent
property
terms
small
interference
RNA
silencing
plasmid
DNA
editing,
thus
revealing
a
great
different
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 23889 - 23902
Опубликована: Ноя. 25, 2023
Development
of
a
nanoscale
drug
delivery
system
that
can
simultaneously
exert
efficient
tumor
therapeutic
efficacy
while
creating
the
desired
antitumor
immune
responses
is
still
challenging.
Herein,
we
report
use
manganese
dioxide
(MnO2)-entrapping
dendrimer
nanocarrier
to
codeliver
glucose
oxidase
(GOx)
and
cyclic
GMP-AMP
(cGAMP),
an
agonist
stimulator
interferon
genes
(STING)
for
improved
chemodynamic/starvation/immune
therapy.
Methoxy
poly(ethylene
glycol)
(mPEG)-
phenylboronic
acid
(PBA)-modified
generation
5
(G5)
poly(amidoamine)
dendrimers
were
first
synthesized
then
entrapped
with
MnO2
nanoparticles
(NPs)
generate
hybrid
MnO2@G5-mPEG–PBA
(MGPP)
NPs.
The
created
MGPP
NPs
core
size
2.8
nm
display
glutathione
depletion
ability,
favorable
Mn2+
release
profile
under
microenvironment
mimetic
condition
enable
Fenton-like
reaction
T1-weighted
magnetic
resonance
(MR)
imaging.
We
show
MGPP-mediated
GOx
facilitates
enhanced
chemodynamic/starvation
therapy
cancer
cells
in
vitro,
further
codelivery
cGAMP
effectively
trigger
immunogenic
cell
death
(ICD)
strongly
promote
maturation
dendritic
cells.
In
bilateral
mouse
colorectal
model,
nanosystem
elicits
potent
performance
strong
abscopal
effect,
greatly
improving
overall
survival
rate.
Importantly,
dendrimer-mediated
not
only
allows
coordination
respective
chemodynamic/starvation-triggered
ICD
augmented
STING
activation
boost
systemic
responses,
but
also
enables
MR
imaging,
potentially
serving
as
promising
nanoplatform
responses.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Апрель 5, 2024
Abstract
Rapid
advances
in
nanotechnology
have
made
it
possible
to
combine
photothermal
therapy
(PTT)
with
immunotherapy,
enabling
activate
an
situ
vaccine
effect.
However,
this
effect
is
severely
impeded
by
low
antigen
presentation
level
and
highly
suppressive
tumor
immune
microenvironment
(immune
“cold”
tumors).
To
overcome
the
obstacles,
multifunctional
carrier‐free
nanoparticles
(FCDP‐NPs)
assembled
from
Fe
2+
,
toll‐like
receptor
9
agonist
(CpG),
cationic
lipid
(DOTAP)
agent
polydopamine
are
developed.
After
intratumoral
injection,
FCDP‐NPs
carrying
positive
charge
exposed
under
laser
irradiation,
which
can
capture
tumor‐associated
antigens
(TAAs)
generated
upon
post‐PTT
form
nanovaccines
(FCD‐NPs@TAAs).
The
further
promote
cross‐presentation
of
TAAs,
stimulate
adaptive
responses,
shape
“hot”
tumors.
As
a
result,
improve
survival
rates
elicit
durable
memory
that
remarkedly
prevents
metastasis,
illustrating
useful
platform
for
PTT
synergized
immunotherapy.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(2)
Опубликована: Март 1, 2024
Abstract
The
application
of
nanotechnology
in
biological
and
medical
fields
have
resulted
the
creation
new
devices,
supramolecular
systems,
structures,
complexes,
composites.
Dendrimers
are
relatively
nanotechnological
polymers
with
unique
features;
they
globular
shape,
a
topological
structure
formed
by
monomeric
subunit
branches
diverging
to
sides
from
central
nucleus.
This
review
analyzes
main
features
dendrimers
their
applications
biology
medicine
regarding
cancer
treatment.
that
include
drug
gene
carriers,
antioxidant
agents,
imaging
adjuvants,
but
importantly,
can
create
complex
nanosized
constructions
combine
such
as
drug/gene
carriers
agents.
Dendrimer‐based
nanosystems
different
metals
enhance
oxidative
stress,
polyethylene
glycol
provide
biosafety,
an
agent
(a
fluorescent,
radioactive,
magnetic
resonance
probe),
or/and
nucleic
acid
provides
single
or
dual
action
on
cells
tissues.
One
major
benefit
is
easy
release
body
(in
contrast
metal
nanoparticles,
fullerenes,
carbon
nanotubes),
allowing
biosafe
constructions.
Some
already
clinically
approved
being
used
drugs,
many
nanocomplexes
currently
studied
for
clinical
practice.
In
summary,
very
useful
tool
nanoconstructions
personalized
nanomedicine.
article
categorized
under:
Diagnostic
Tools
>
Nanodevices
Vivo
Nanodiagnostics
Imaging
Therapeutic
Approaches
Drug
Discovery
Nanomedicine
Oncologic
Disease
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(14), С. 17285 - 17299
Опубликована: Март 28, 2024
Cytoprotective
autophagy
and
an
immunosuppressive
tumor
microenvironment
(TME)
are
two
positive
promoters
for
proliferation
metastasis
that
severely
hinder
therapeutic
efficacy.
Inhibiting
reconstructing
TME
toward
macrophage
activation
simultaneously
of
great
promise
effective
elimination,
yet
still
a
huge
challenge.
Herein,
kind
dendrimer-based
proton
sponge
nanocomposites
was
designed
constructed
chemo/chemodynamic/immunotherapy
through
inhibition-promoted
cell
apoptosis
repolarization-enhanced
immune
response.
These
obtained
contain
G5AcP
dendrimer,
Fenton-like
agent
Cu(II),
chemical
drug
doxorubicin
(DOX).
When
accumulated
in
regions,
can
act
as
immunomodulator
to
realize
deacidification-promoted
repolarization
antitumoral
type,
which
then
secretes
inflammatory
cytokines
activate
T
cells.
They
also
regulate
intracellular
lysosomal
pH
inhibit
cytoprotective
autophagy.
The
released
Cu(II)
DOX
induce
aggravated
damage
reaction
chemotherapeutic
effect
this
autophagy-inhibition
condition.
Tumor-associated
antigens
from
these
dying
cells
promote
the
maturity
dendritic
cells,
further
activating
Effective
elimination
be
achieved
by
strategy,
providing
significant
guidance
design
promising
antitumor
nanomedicine.
Science and Innovations,
Год журнала:
2025,
Номер
1(1), С. 78 - 83
Опубликована: Фев. 18, 2025
Every
year
there
is
a
rapid
increase
in
cancer,
which
one
of
the
main
causes
death.
Methods
used
to
treat
cancer
often
do
not
produce
desired
results
and
can
cause
various
side
effects.
Therefore,
effectively
combat
it
necessary
find
new
solutions.
The
use
nanotechnology
opens
up
opportunities
diagnosis
treatment
human
malignant
tumors.
Nanoparticles
antitumor
therapy
act
as
carriers
drugs
nucleic
acids,
also
reduce
toxicity
anticancer
drugs.
This
review
devoted
analysis
interaction
nanomaterials
with
small
RNAs.
Data
are
presented
on
some
non-toxic
effective
multifunctional
nanoconjugates
gene
for
cancer.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(4)
Опубликована: Фев. 17, 2024
To
realize
precise
tumor
treatment,
chemodynamic
therapy
(CDT)
that
utilizes
metal
element
to
trigger
Fenton
or
Fenton‐like
reaction
generate
cytotoxic
hydroxyl
radicals
in
region
has
been
widely
investigated.
Recently,
the
dendrimers
featured
with
abundant
surface
functional
groups
and
excellent
biocompatibility
are
regarded
as
promising
carriers
of
elements
for
delivery.
Much
effort
devoted
design
dendrimer‐based
nanodrugs
CDT
CDT‐involved
synergistic
tumors.
Herein,
recent
advances
construction
(in
most
cases,
poly(amidoamine)
dendrimers)
CDT,
CDT/chemotherapy,
CDT/phototherapy,
CDT/gene
therapy,
multimodal
reviewed.
Furthermore,
future
perspectives
regard
development
treatment
also
briefly
discussed.
