Structural and Property Characterizations of Dual‐Responsive Core–Shell Tecto Dendrimers for Tumor Penetration and Gene Delivery Applications DOI
Junjie Liu, Xiaoyu Wang, Xiaolei Li

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(17)

Published: May 30, 2024

Core-shell tecto dendrimers (CSTDs) with excellent physicochemical properties and good tumor penetration gene transfection efficiency have been demonstrated to the potential replace high-generation in biomedical applications. However, their characterization related biological of CSTDs for enhanced delivery still lack in-depth investigation. Herein, three types dual-responsive are designed thorough investigation efficiency. Three prepared through phenylborate ester bonds phenylboronic acid (PBA)-decorated generation 5 (G5) poly(amidoamine) (PAMAM) as cores monose (galactose, glucose, or mannose)-conjugated G3 PAMAM shells thoroughly characterized via NMR other techniques. It is shown that produced display strong correlation signals between PBA protons, similar hydrodynamic diameters, dual reactive oxygen species- pH-responsivenesses. The proven structure-dependent property terms small interference RNA silencing plasmid DNA editing, thus revealing a great different

Language: Английский

Manganese Dioxide-Entrapping Dendrimers Co-Deliver Protein and Nucleotide for Magnetic Resonance Imaging-Guided Chemodynamic/Starvation/Immune Therapy of Tumors DOI
Yue Gao,

Zhijun Ouyang,

Siyan Shen

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 23889 - 23902

Published: Nov. 25, 2023

Development of a nanoscale drug delivery system that can simultaneously exert efficient tumor therapeutic efficacy while creating the desired antitumor immune responses is still challenging. Herein, we report use manganese dioxide (MnO2)-entrapping dendrimer nanocarrier to codeliver glucose oxidase (GOx) and cyclic GMP-AMP (cGAMP), an agonist stimulator interferon genes (STING) for improved chemodynamic/starvation/immune therapy. Methoxy poly(ethylene glycol) (mPEG)- phenylboronic acid (PBA)-modified generation 5 (G5) poly(amidoamine) dendrimers were first synthesized then entrapped with MnO2 nanoparticles (NPs) generate hybrid MnO2@G5-mPEG–PBA (MGPP) NPs. The created MGPP NPs core size 2.8 nm display glutathione depletion ability, favorable Mn2+ release profile under microenvironment mimetic condition enable Fenton-like reaction T1-weighted magnetic resonance (MR) imaging. We show MGPP-mediated GOx facilitates enhanced chemodynamic/starvation therapy cancer cells in vitro, further codelivery cGAMP effectively trigger immunogenic cell death (ICD) strongly promote maturation dendritic cells. In bilateral mouse colorectal model, nanosystem elicits potent performance strong abscopal effect, greatly improving overall survival rate. Importantly, dendrimer-mediated not only allows coordination respective chemodynamic/starvation-triggered ICD augmented STING activation boost systemic responses, but also enables MR imaging, potentially serving as promising nanoplatform responses.

Language: Английский

Citations

39
Cascade Carrier‐Free Nanoparticles Forming In Situ Nanovaccines for Synergistic Photothermal‐Immunotherapy of Cancer DOI
Chenlu Huang, Hanyong Wang, Xinyu Yang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: April 5, 2024

Abstract Rapid advances in nanotechnology have made it possible to combine photothermal therapy (PTT) with immunotherapy, enabling activate an situ vaccine effect. However, this effect is severely impeded by low antigen presentation level and highly suppressive tumor immune microenvironment (immune “cold” tumors). To overcome the obstacles, multifunctional carrier‐free nanoparticles (FCDP‐NPs) assembled from Fe 2+ , toll‐like receptor 9 agonist (CpG), cationic lipid (DOTAP) agent polydopamine are developed. After intratumoral injection, FCDP‐NPs carrying positive charge exposed under laser irradiation, which can capture tumor‐associated antigens (TAAs) generated upon post‐PTT form nanovaccines (FCD‐NPs@TAAs). The further promote cross‐presentation of TAAs, stimulate adaptive responses, shape “hot” tumors. As a result, improve survival rates elicit durable memory that remarkedly prevents metastasis, illustrating useful platform for PTT synergized immunotherapy.

Language: Английский

Citations

15
Nanocodelivery of an NIR photothermal agent and an acid-responsive TLR7 agonist prodrug to enhance cancer photothermal immunotherapy and the abscopal effect DOI
Bo Chen, Ruijie Huang, Wei Zeng

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122434 - 122434

Published: Dec. 17, 2023

Language: Английский

Citations

16
Recent advances in multifunctional dendrimer‐based complexes for cancer treatment DOI
Dzmitry Shcharbin,

Viktoria Zhogla,

Viktar Abashkin

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(2)

Published: March 1, 2024

Abstract The application of nanotechnology in biological and medical fields have resulted the creation new devices, supramolecular systems, structures, complexes, composites. Dendrimers are relatively nanotechnological polymers with unique features; they globular shape, a topological structure formed by monomeric subunit branches diverging to sides from central nucleus. This review analyzes main features dendrimers their applications biology medicine regarding cancer treatment. that include drug gene carriers, antioxidant agents, imaging adjuvants, but importantly, can create complex nanosized constructions combine such as drug/gene carriers agents. Dendrimer‐based nanosystems different metals enhance oxidative stress, polyethylene glycol provide biosafety, an agent (a fluorescent, radioactive, magnetic resonance probe), or/and nucleic acid provides single or dual action on cells tissues. One major benefit is easy release body (in contrast metal nanoparticles, fullerenes, carbon nanotubes), allowing biosafe constructions. Some already clinically approved being used drugs, many nanocomplexes currently studied for clinical practice. In summary, very useful tool nanoconstructions personalized nanomedicine. article categorized under: Diagnostic Tools > Nanodevices Vivo Nanodiagnostics Imaging Therapeutic Approaches Drug Discovery Nanomedicine Oncologic Disease

Language: Английский

Citations

5
Multifunctional hydrogels based on photothermal therapy: A prospective platform for the postoperative management of melanoma DOI

Wen-Shang Liu,

Zhuo Chen, Zhengmao Lu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 406 - 428

Published: June 8, 2024

Language: Английский

Citations

5
Proton Sponge Nanocomposites for Synergistic Tumor Elimination via Autophagy Inhibition-Promoted Cell Apoptosis and Macrophage Repolarization-Enhanced Immune Response DOI
Yifan Duan, Wei Zhang, Yi Ouyang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(14), P. 17285 - 17299

Published: March 28, 2024

Cytoprotective autophagy and an immunosuppressive tumor microenvironment (TME) are two positive promoters for proliferation metastasis that severely hinder therapeutic efficacy. Inhibiting reconstructing TME toward macrophage activation simultaneously of great promise effective elimination, yet still a huge challenge. Herein, kind dendrimer-based proton sponge nanocomposites was designed constructed chemo/chemodynamic/immunotherapy through inhibition-promoted cell apoptosis repolarization-enhanced immune response. These obtained contain G5AcP dendrimer, Fenton-like agent Cu(II), chemical drug doxorubicin (DOX). When accumulated in regions, can act as immunomodulator to realize deacidification-promoted repolarization antitumoral type, which then secretes inflammatory cytokines activate T cells. They also regulate intracellular lysosomal pH inhibit cytoprotective autophagy. The released Cu(II) DOX induce aggravated damage reaction chemotherapeutic effect this autophagy-inhibition condition. Tumor-associated antigens from these dying cells promote the maturity dendritic cells, further activating Effective elimination be achieved by strategy, providing significant guidance design promising antitumor nanomedicine.

Language: Английский

Citations

4
Photoluminescent assay and imaging for effective modulation of photothermal events on enhanced cancer therapy developed via analytical techniques DOI
Tianyou Wang, Hang Zhang, Zhaoyin Wang

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118188 - 118188

Published: Feb. 1, 2025

Language: Английский

Citations

0
Dendrimer multifunctional complexes for genetic therapy of cancer DOI Open Access

A. Stanovaya,

M. Terekhova,

Viktar Abashkin

et al.

Science and Innovations, Journal Year: 2025, Volume and Issue: 1(1), P. 78 - 83

Published: Feb. 18, 2025

Every year there is a rapid increase in cancer, which one of the main causes death. Methods used to treat cancer often do not produce desired results and can cause various side effects. Therefore, effectively combat it necessary find new solutions. The use nanotechnology opens up opportunities diagnosis treatment human malignant tumors. Nanoparticles antitumor therapy act as carriers drugs nucleic acids, also reduce toxicity anticancer drugs. This review devoted analysis interaction nanomaterials with small RNAs. Data are presented on some non-toxic effective multifunctional nanoconjugates gene for cancer.

Language: Английский

Citations

0
Nanocarriers for cutting-edge cancer immunotherapies DOI Creative Commons
Joyce Hu, Pooria Mohammadi Arvejeh,

S Bone

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 15, 2025

Cancer immunotherapy aims to harness the body's own immune system for effective and long-lasting elimination of malignant neoplastic tissues. Owing advance in understanding cancer pathology immunology, many novel strategies enhancing immunological responses against various cancers have been successfully developed, some translated into excellent clinical outcomes. As one promising strategy next generation immunotherapies, activating multi-cellular network (MCN) within tumor microenvironment (TME) deploy multiple mechanisms action (MOAs) has attracted significant attention. To achieve this effectively safely, delivering or pleiotropic therapeutic cargoes targeted sites cancerous tissues, cells, intracellular organelles is critical, which numerous nanocarriers developed leveraged. In review, we first introduce payloads categorized according their predicted functions physicochemical structures forms. Then, nanocarriers, along with unique characteristics, properties, advantages, limitations, are introduced notable recent applications immunotherapy. Following discussions on targeting strategies, a summary each nanocarrier matching suitable provided comprehensive background information designing regimens.

Language: Английский

Citations

0
Dendrimer‐Based Nanodrugs for Chemodynamic Therapy of Tumors DOI Creative Commons
Caiyun Zhang, Yunqi Guo, Mingwu Shen

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 17, 2024

To realize precise tumor treatment, chemodynamic therapy (CDT) that utilizes metal element to trigger Fenton or Fenton‐like reaction generate cytotoxic hydroxyl radicals in region has been widely investigated. Recently, the dendrimers featured with abundant surface functional groups and excellent biocompatibility are regarded as promising carriers of elements for delivery. Much effort devoted design dendrimer‐based nanodrugs CDT CDT‐involved synergistic tumors. Herein, recent advances construction (in most cases, poly(amidoamine) dendrimers) CDT, CDT/chemotherapy, CDT/phototherapy, CDT/gene therapy, multimodal reviewed. Furthermore, future perspectives regard development treatment also briefly discussed.

Language: Английский

Citations

3